The combination of defective immune tolerance and external triggers is thought to underlie the pathophysiology of autoimmune hepatitis.1,2 Some polymorphisms associated with susceptibility to autoimmune hepatitis have...The combination of defective immune tolerance and external triggers is thought to underlie the pathophysiology of autoimmune hepatitis.1,2 Some polymorphisms associated with susceptibility to autoimmune hepatitis have been reported,and some cases have been described in patients with monogenic primary immune deficiencies or systemic diseases.展开更多
基金supported by the Institut National de la Santéet de la Recherche Médicale(INSERM)and by government grants managed by the Agence Nationale de la Recherche as part of the“Investment for the Future”program(Institut Hospitalo-Universitaire Imagine,grant ANR-10-IAHU-01,Recherche Hospitalo-Universitaire,grant ANR-18-RHUS-0010)the Centre de Référence Déficits Immunitaires Héréditaires(CEREDIH),the Agence National de la Recherche(ANR-14-CE14-0026-01“Lumugene”+1 种基金ANR-18-CE17-0001“Action”ANR-22-CE15-0047-02《BREAK-ITP》),the Fondation pour la recherche Médicale(FRM:EQU202103012670).
文摘The combination of defective immune tolerance and external triggers is thought to underlie the pathophysiology of autoimmune hepatitis.1,2 Some polymorphisms associated with susceptibility to autoimmune hepatitis have been reported,and some cases have been described in patients with monogenic primary immune deficiencies or systemic diseases.
