Albumin-bilirubin score in non-malignant liver diseases should be properly validated

The albumin-bilirubin(ALBI)score to assess the risk of decompensation in patients with initially compensated cirrhosis may improve their prognostic evaluation.This letter critically evaluates the research,which utilizes the ALBI score to forecast decompensation in cirrhosis patients over a three-year period.This score was initially developed to assess liver function in hepatocellular carcinoma,its prognostic utility for non-malignant liver diseases has now been explored,recognizing decompensation as a pivotal event that significantly affects patient’s survival.Some concerns regarding the methodology of this research may be raised,particularly the exclusive use of radiological diagnosis,potentially including patients without definite cirrhosis and thus skewing the decompensation risk assessment.The reported predominance of variceal bleeding as a decompensating event conflicts with established literature,that often reports ascites as the initial decompensation manifestation.The letter highlights the absence of details on esophageal varices and their management,which could introduce bias in evaluating the ALBI score's predictive power.Furthermore,the letter points out the small sample size of patients with high-risk ALBI grades,potentially compromising the score's validity in this context.We suggest prospective future research to investigate the dynamic changes in the ALBI score over time to reinforce the validity of the ALBI score as a predictor of decompensation in non-malignant liver disease.

轮胎形态变化的仿真技术

轮胎形态变化仿真技术可以在汽车开发的早期阶段向汽车制造商提供装配不同轮胎和轮辋型号的预测数据。这项仿真技术具有进一步应用的潜在价值。在汽车早期设计阶段,需要考虑的有关轮胎的重要问题包括:应该选择哪种规格的轮胎和轮辋,设定最佳的轮胎充气内压,如何才能通过对轮胎的改进获得接近轮胎实测值的重要性能指标,这些数据与汽车的相关性有多大?轮胎模型软件CD Tire/3D是可以在第一个实体样品出现之前用来预测轮胎性能的新软件,可以解决上述问题。