Objectives:To test hypothesized associations between the ABO blood group(ABO-bg)system and the pathological features of prostate cancer(PCa).Material and methods:Between January 2013 and September 2019,1173 patients u...Objectives:To test hypothesized associations between the ABO blood group(ABO-bg)system and the pathological features of prostate cancer(PCa).Material and methods:Between January 2013 and September 2019,1173 patients underwent radical prostatectomy.Associations between ABO-bg levels and pathological features were evaluated using statistical methods.Results:Overall,1149 consecutive patients were evaluated using the ABO-bg system,which was represented by O-bg(42.8%)and A-bg(41.3%),followed by B-bg(11.1%)and AB-bg(4.8%).Only positive surgical margins(PSMs)was correlated with ABO-bg(Pearson correlation coefficient,r=0.071;p=0.017),and the risk was increased in group-O(odds ratio[OR],1.497;95%confidence interval,1.149-1.950;p=0.003)versus non-O-bg.In clinical and pathological models,O-bg was at increased risk of PSM after the adjustment for prostate-specific antigen,percentage of biopsy-positive cores,and high surgical volume(adjusted OR,1.546;95%confidence interval,1.180-2.026;p=0.002);however,the adjusted OR did not change after the adjustment for tumor load and stage as well as high surgical volume.Conclusions:In clinical PCa,the risk of PSM was higher in O-bg versus non-O-bg patients after the adjustment for standard predictors.Confirmatory studies are needed to confirm the association between ABO-bg and unfavorable PCa features.展开更多
文摘Objectives:To test hypothesized associations between the ABO blood group(ABO-bg)system and the pathological features of prostate cancer(PCa).Material and methods:Between January 2013 and September 2019,1173 patients underwent radical prostatectomy.Associations between ABO-bg levels and pathological features were evaluated using statistical methods.Results:Overall,1149 consecutive patients were evaluated using the ABO-bg system,which was represented by O-bg(42.8%)and A-bg(41.3%),followed by B-bg(11.1%)and AB-bg(4.8%).Only positive surgical margins(PSMs)was correlated with ABO-bg(Pearson correlation coefficient,r=0.071;p=0.017),and the risk was increased in group-O(odds ratio[OR],1.497;95%confidence interval,1.149-1.950;p=0.003)versus non-O-bg.In clinical and pathological models,O-bg was at increased risk of PSM after the adjustment for prostate-specific antigen,percentage of biopsy-positive cores,and high surgical volume(adjusted OR,1.546;95%confidence interval,1.180-2.026;p=0.002);however,the adjusted OR did not change after the adjustment for tumor load and stage as well as high surgical volume.Conclusions:In clinical PCa,the risk of PSM was higher in O-bg versus non-O-bg patients after the adjustment for standard predictors.Confirmatory studies are needed to confirm the association between ABO-bg and unfavorable PCa features.
