Kidney transplantation is the best option for kidney replacement therapy,even considering that most of the times the grafts do not survive as long as their recipients.In the Khalil et al's experience,published in ...Kidney transplantation is the best option for kidney replacement therapy,even considering that most of the times the grafts do not survive as long as their recipients.In the Khalil et al's experience,published in this issue of the Journal,they analyze their second kidney graft survival and describe those significant predictors of early loss.This editorial comments on the results and put in perspective that most of the times,long-term graft survival could be inadvertently jeopardized if the immunosuppressive therapy is reduced or withdrawn for any reason,and that it could happen frequently if the transplant physician intends to innovate with the clinical care without proper evidence-based data.展开更多
The probability of developing primary dysfunction(PD)is a function of the probability of ischemia/reperfusion(I/R)injury.The probability of I/R injury in turn,is a function of several donor and transplantation process...The probability of developing primary dysfunction(PD)is a function of the probability of ischemia/reperfusion(I/R)injury.The probability of I/R injury in turn,is a function of several donor and transplantation process variables,among which is ischemia time.Custodio et al studied the duration of a special type of warm ischemia and showed,contrary to what is known,that a longer duration is not statistically different from a shorter one in PD development.This finding opens the door to the unforeseen opportunity of training fellows in performing hepatectomies,since the duration will not jeopardize liver transplant outcomes,albeit with some precautions.展开更多
文摘Kidney transplantation is the best option for kidney replacement therapy,even considering that most of the times the grafts do not survive as long as their recipients.In the Khalil et al's experience,published in this issue of the Journal,they analyze their second kidney graft survival and describe those significant predictors of early loss.This editorial comments on the results and put in perspective that most of the times,long-term graft survival could be inadvertently jeopardized if the immunosuppressive therapy is reduced or withdrawn for any reason,and that it could happen frequently if the transplant physician intends to innovate with the clinical care without proper evidence-based data.
文摘The probability of developing primary dysfunction(PD)is a function of the probability of ischemia/reperfusion(I/R)injury.The probability of I/R injury in turn,is a function of several donor and transplantation process variables,among which is ischemia time.Custodio et al studied the duration of a special type of warm ischemia and showed,contrary to what is known,that a longer duration is not statistically different from a shorter one in PD development.This finding opens the door to the unforeseen opportunity of training fellows in performing hepatectomies,since the duration will not jeopardize liver transplant outcomes,albeit with some precautions.
