Intensive past research has demonstrated that cytochrome P450 monooxygenases are involved in the biosynthesis of numerous natural products and in human metabolism of various pharmaceuticals [1]. This inspired syntheti...Intensive past research has demonstrated that cytochrome P450 monooxygenases are involved in the biosynthesis of numerous natural products and in human metabolism of various pharmaceuticals [1]. This inspired synthetic organic and pharmaceutical chemists to test them as catalysts in the oxidative hydroxylation of steroids. Unfortunately, wildtype P450s generally proved to show low levels of regio-and diastereoselectivity as well as suboptimal activity.展开更多
This review article critically compares two widely used types of catalysis,chemo-and biocatalysis,and provides insights on their greenness according to specified parameters.A comparative analysis of the environmental ...This review article critically compares two widely used types of catalysis,chemo-and biocatalysis,and provides insights on their greenness according to specified parameters.A comparative analysis of the environmental impact of chemo-and biocatalytic oxyfunctionalisation reactions based on published experimental data reveals that both methods produce comparable amounts of waste,with the majority stemming from the solvent used.However,it is emphasised that the synthesis of the catalysts themselves,including biocatalysts,should also be considered when assessing their environmental impact.The review underscores the complexity of assessing the environmental impact of catalytic oxyfunctionalisation reactions.The article also discusses the relationship between solvent properties and the energy demands for chemical transformations and downstream processing,underlining that the choice of solvent can significantly influence the environmental impact of a catalytic process.Additionally,the review highlights the importance of considering the recyclability of reagents and the secondary CO_(2)emissions caused by the energy requirements of the reaction when evaluating the environmental impact of a catalytic process.Each chemo-and biocatalysis produce a certain environmental impact,the greenness of either method is dependent on several factors,including the type of waste generated,the recyclability of reagents,and secondary CO_(2)emissions.This review therefore recommends using consistent metrics and a comprehensive life cycle assessment approach to evaluate this environmental impact,and highlights the importance of considering the synthesis of the catalysts themselves.展开更多
文摘Intensive past research has demonstrated that cytochrome P450 monooxygenases are involved in the biosynthesis of numerous natural products and in human metabolism of various pharmaceuticals [1]. This inspired synthetic organic and pharmaceutical chemists to test them as catalysts in the oxidative hydroxylation of steroids. Unfortunately, wildtype P450s generally proved to show low levels of regio-and diastereoselectivity as well as suboptimal activity.
基金Funded by the European Union(ERC,PeroxyZyme,No101054658).
文摘This review article critically compares two widely used types of catalysis,chemo-and biocatalysis,and provides insights on their greenness according to specified parameters.A comparative analysis of the environmental impact of chemo-and biocatalytic oxyfunctionalisation reactions based on published experimental data reveals that both methods produce comparable amounts of waste,with the majority stemming from the solvent used.However,it is emphasised that the synthesis of the catalysts themselves,including biocatalysts,should also be considered when assessing their environmental impact.The review underscores the complexity of assessing the environmental impact of catalytic oxyfunctionalisation reactions.The article also discusses the relationship between solvent properties and the energy demands for chemical transformations and downstream processing,underlining that the choice of solvent can significantly influence the environmental impact of a catalytic process.Additionally,the review highlights the importance of considering the recyclability of reagents and the secondary CO_(2)emissions caused by the energy requirements of the reaction when evaluating the environmental impact of a catalytic process.Each chemo-and biocatalysis produce a certain environmental impact,the greenness of either method is dependent on several factors,including the type of waste generated,the recyclability of reagents,and secondary CO_(2)emissions.This review therefore recommends using consistent metrics and a comprehensive life cycle assessment approach to evaluate this environmental impact,and highlights the importance of considering the synthesis of the catalysts themselves.
