In the adult brain,neural stem cells have been found in two major niches:the hippocampus and the olfactory bulb.Neurons derived from these stem cells contribute to learning,memory,and the autonomous repair of the brai...In the adult brain,neural stem cells have been found in two major niches:the hippocampus and the olfactory bulb.Neurons derived from these stem cells contribute to learning,memory,and the autonomous repair of the brain under pathological conditions.Hence,the physi-ology of adult neural stem cells has become a signifi-cant component of research on synaptic plasticity and neuronal disorders.In addition,the recently developed induced pluripotent stem cell technique provides a powerful tool for researchers engaged in the patho-logical and pharmacological study of neuronal disor-ders.In this review,we briefly summarize the research progress in neural stem cells in the adult brain and in the neuropathological application of the induced pluripotent stem cell technique.展开更多
Neuropsychiatric disorders are complex disorders characterized by heterogeneous genetic variations,variable symptoms,and widespread changes in anatomical pathology.In the context of neuropsychiatric disorders,limited ...Neuropsychiatric disorders are complex disorders characterized by heterogeneous genetic variations,variable symptoms,and widespread changes in anatomical pathology.In the context of neuropsychiatric disorders,limited access to relevant tissue types presents challenges for understanding disease etiology and developing effective treatments.Induced pluripotent stem cells(iPSCs)reprogrammed from patient somatic cells offer an opportunity to recapitulate disease development in relevant cell types,and they provide novel approaches for understanding disease mechanisms and for development of effective treatments.Here we review recent progress and challenges in differentiation paradigms for generating disease-relevant cells and recent studies of neuropsychiatric disorders using human pluripotent stem cell(hPSC)models where cellular phenotypes linked to disease have been reported.The use of iPSC-based disease models holds great promise for understanding disease mechanisms and supporting discovery of effective treatments.展开更多
Erratum to:Protein Cell 2012,3(4):251-261 DOI 10.1007/s13238-012-2033-61."In the adult brain,neural stem cells have been found in two major niches:the hippocampus and the olfactory bulb"should be changed to:...Erratum to:Protein Cell 2012,3(4):251-261 DOI 10.1007/s13238-012-2033-61."In the adult brain,neural stem cells have been found in two major niches:the hippocampus and the olfactory bulb"should be changed to:"In the adult brain,neural stem cells have been found in two major niches:the dentate gyrus and the subventricular zone"in the first sentence in the abstract.展开更多
基金supported by an American Heart Association postdoctoral fellowship(11POST5720016).
文摘In the adult brain,neural stem cells have been found in two major niches:the hippocampus and the olfactory bulb.Neurons derived from these stem cells contribute to learning,memory,and the autonomous repair of the brain under pathological conditions.Hence,the physi-ology of adult neural stem cells has become a signifi-cant component of research on synaptic plasticity and neuronal disorders.In addition,the recently developed induced pluripotent stem cell technique provides a powerful tool for researchers engaged in the patho-logical and pharmacological study of neuronal disor-ders.In this review,we briefly summarize the research progress in neural stem cells in the adult brain and in the neuropathological application of the induced pluripotent stem cell technique.
基金supported by the Paul G.Allen Family Foundation,the National Institutes of Health U01#MH106882the JPB Foundation,the Leona M.and Harry B.Helmsley Charitable Trust(#2017-PG-MED001)Annette Merle-Smith and the Lookout Foundation,and the G.Harold&Leila Y.Mathers Charitable Foundation to F.H.G.
文摘Neuropsychiatric disorders are complex disorders characterized by heterogeneous genetic variations,variable symptoms,and widespread changes in anatomical pathology.In the context of neuropsychiatric disorders,limited access to relevant tissue types presents challenges for understanding disease etiology and developing effective treatments.Induced pluripotent stem cells(iPSCs)reprogrammed from patient somatic cells offer an opportunity to recapitulate disease development in relevant cell types,and they provide novel approaches for understanding disease mechanisms and for development of effective treatments.Here we review recent progress and challenges in differentiation paradigms for generating disease-relevant cells and recent studies of neuropsychiatric disorders using human pluripotent stem cell(hPSC)models where cellular phenotypes linked to disease have been reported.The use of iPSC-based disease models holds great promise for understanding disease mechanisms and supporting discovery of effective treatments.
文摘Erratum to:Protein Cell 2012,3(4):251-261 DOI 10.1007/s13238-012-2033-61."In the adult brain,neural stem cells have been found in two major niches:the hippocampus and the olfactory bulb"should be changed to:"In the adult brain,neural stem cells have been found in two major niches:the dentate gyrus and the subventricular zone"in the first sentence in the abstract.
