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X chromosome inactivation and active X upregulation in therian mammals: facts, questions, and hypotheses
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作者 Reiner A.Veitia frederic veyrunes +1 位作者 Samuel Bottani James A.Birchler 《Journal of Molecular Cell Biology》 SCIE CAS CSCD 2015年第1期2-11,共10页
X chromosome inactivation is a mechanism that modulates the expression of X-linked genes in eutherian females(XX).Ohno proposed that to achieve a proper balance between X-linked and autosomal genes,those on the active... X chromosome inactivation is a mechanism that modulates the expression of X-linked genes in eutherian females(XX).Ohno proposed that to achieve a proper balance between X-linked and autosomal genes,those on the active X should also undergo a 2-fold upregula-tion.Although some support for Ohno's hypothesis has been provided through the years,recent genomic studies testing this hypoth-esis have brought contradictory results and fueled debate.Thus far,there are as many results in favor as against Ohno's hypothesis,depending on the nature of the datasets and the various assumptions and thresholds involved in the analyses.However,they have con-firmed the importance of dosage balance between X-linked and autosomal genes involved in stoichiometric relationships.These facts as well as questions and hypotheses are discussed below. 展开更多
关键词 X inactivation X chromosome upregulation monoallelic expression IMPRINTING dosage balance
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