The measurement of specific-locus mutations in various eukaryotic organismshas been used as a mechanism to estimate the genetic consequences of humanexposure to environmental mutagens.Specific-iocus assays are usually...The measurement of specific-locus mutations in various eukaryotic organismshas been used as a mechanism to estimate the genetic consequences of humanexposure to environmental mutagens.Specific-iocus assays are usually confined tosingle genes and measure various types of genetic damage ranging from single base-pair substitutions to multilocus deletions.Not all such assays measure the samerange of genetic damage.Thus.different specific-locus assays may provide differentdata,both quantitative and qualitative.as a result of exposure to the sameenvironmental mutagen.The specific-locus assay in the ad-3 region of Neurosporacrassa measures genetic damage at 2 closely linked loci as well as other loci in thegenome.As a result.this assay permits a comprehensive evaluation of the types ofgenetic damage produced by different environmental mutagens.In this paper.thespectrum of genetic damage that can be detected in Neurospora is reviewed andcompared with other eukaryotic systems.展开更多
文摘The measurement of specific-locus mutations in various eukaryotic organismshas been used as a mechanism to estimate the genetic consequences of humanexposure to environmental mutagens.Specific-iocus assays are usually confined tosingle genes and measure various types of genetic damage ranging from single base-pair substitutions to multilocus deletions.Not all such assays measure the samerange of genetic damage.Thus.different specific-locus assays may provide differentdata,both quantitative and qualitative.as a result of exposure to the sameenvironmental mutagen.The specific-locus assay in the ad-3 region of Neurosporacrassa measures genetic damage at 2 closely linked loci as well as other loci in thegenome.As a result.this assay permits a comprehensive evaluation of the types ofgenetic damage produced by different environmental mutagens.In this paper.thespectrum of genetic damage that can be detected in Neurospora is reviewed andcompared with other eukaryotic systems.
