Objective. Arterial oxygen saturation (SaO2) and arterial carbon dioxide partial pressure (PaCO2) are 2 of the most important respiratory parameters in the treatment of critically ill neonates. Noninvasive monitoring ...Objective. Arterial oxygen saturation (SaO2) and arterial carbon dioxide partial pressure (PaCO2) are 2 of the most important respiratory parameters in the treatment of critically ill neonates. Noninvasive monitoring of these parameters is desirable for continuous estimating of the respiratory status and reducing blood loss because of repeated blood gas analyses. Transcutaneous measurement of PCO2 (PtcCO2) represents a simple and noninvasive technique for continuous monitoring of ventilation. However, sensor preparation, positioning, taping, and repeated changes of the sensor location make the handling difficult and complicate its use in the neonatal care unit. Recently, a new sensor for combined assessment o f pulse oximetry oxygen saturation (SpO2) and PtcCO2 has been introduced (TOSCA Monitor; Linde Medical Sensors, Basel, Switzerland). The monitor combines pulse oximetry and PtcCO2 measurement in a single ear sensor, which works at 42°C to enhance blood flow in capillaries below the sensor. Methods. In a prospective, open, nonrandomized study of 60 ill neonates, the new ear sensor for combined assessment of SpO2 and PtcCO2 at 42°C was tested. The sensor was adapted to the ear of a neonate with a Varihesive layer (Conva Tec; Princeton, NJ). Data obtained from the ear sensor were compared with SpO2 Finger/Heel, SaO2, and PaCO2 obtained from arterial blood gas in 30 patients and with a capillary blood gas in an additional 30 patients using Bland Altman bias analysis. Data are presented as median (range). Results. The postconceptional age of the patients was 38.3 weeks (range: 28 5/7-40 5/7) in the arterial group and 37.9 weeks (range: 29 6/7-41 0/7) in the capillary group. Age of the newborns studied was 3.5 days (range: 1-28) in the arterial blood sample group (n = 30) and 6 days (range: 2-28) in the capillary blood sample group (n = 30). Patient weight was 3.02 kg (range: 1.5-4.5) in the arterial group and 2.76 kg (range: 1.0-3.71) in the other group. Three patients had weights of < 1500 g. Twenty-one of 60 patients were conventionally ventilated, 4 patients received high-freque- ncy oscillation, and 35 were not ventilated. Mean difference (bias) and precision (2 SD of the mean difference) between PtcCO2TOSCA and PaCO2 were -0.44 kPa (-3.21 mm Hg) and 0.82 kPa (6.02 mm Hg) and between PtcCO2TOSCA and PcapCO2 were -0.09 kPa (-0.67mm Hg) and 1.11 kPa (8.07 mm Hg), respectively. SpO2 assessment by the TOSCA revealed slightly higher values compared with SaO2 (bias: -0.48%), whereas SpO2Finger/Heel values were slightly lower than SaO2 (bias: 0.52%). Conclusion. The TOSCA monitor with the ear sensor adapted to ears of neonates allows reliable estimation of SaO2 and PaCO2. A potential benefit is the reduction in motion artifacts because of less head movement in new-borns and that onl y a single cable leads form the patient to the monitor. In addition, the sensor is not removed for chest radiograph or for nursing the infant on his or her parent’s lap. Long-term studies in a large population with continuous measurements are required to confirm these preliminary findings and to elucidate the benefits in detection of respiratory deterioration and the potential side effects of this sensor.展开更多
In 127 infants admitted-to intensive care-for RSV bronchiolitis, concomitant bacterial sepsis was a rare even. However, in the subgroup of intubated patients the incidence of bacterial pneumonia was 43.9%(95%CI 31.0-5...In 127 infants admitted-to intensive care-for RSV bronchiolitis, concomitant bacterial sepsis was a rare even. However, in the subgroup of intubated patients the incidence of bacterial pneumonia was 43.9%(95%CI 31.0-56.8%), half community acquired and half nosocomial. As clinical signs are not helpful in identifying these patients, tracheal aspirates have to be investigated microbiologically on a routine basis in order to start antibiotics in time.展开更多
In 127 infants admitted-to intensive care-for RSV bronchiolitis, concomitant bacterial sepsis was a rare even. However, in the subgroup of intubated patients the incidence of bacterial pneumonia was 43.9% (95% CI 31.0...In 127 infants admitted-to intensive care-for RSV bronchiolitis, concomitant bacterial sepsis was a rare even. However, in the subgroup of intubated patients the incidence of bacterial pneumonia was 43.9% (95% CI 31.0-56.8% ), half community acquired and half nosocomial. As clinical signs are not helpful in identifying these patients, tracheal aspirates have to be investigated microbiologically on a routine basis in order to start antibiotics in time.展开更多
文摘Objective. Arterial oxygen saturation (SaO2) and arterial carbon dioxide partial pressure (PaCO2) are 2 of the most important respiratory parameters in the treatment of critically ill neonates. Noninvasive monitoring of these parameters is desirable for continuous estimating of the respiratory status and reducing blood loss because of repeated blood gas analyses. Transcutaneous measurement of PCO2 (PtcCO2) represents a simple and noninvasive technique for continuous monitoring of ventilation. However, sensor preparation, positioning, taping, and repeated changes of the sensor location make the handling difficult and complicate its use in the neonatal care unit. Recently, a new sensor for combined assessment o f pulse oximetry oxygen saturation (SpO2) and PtcCO2 has been introduced (TOSCA Monitor; Linde Medical Sensors, Basel, Switzerland). The monitor combines pulse oximetry and PtcCO2 measurement in a single ear sensor, which works at 42°C to enhance blood flow in capillaries below the sensor. Methods. In a prospective, open, nonrandomized study of 60 ill neonates, the new ear sensor for combined assessment of SpO2 and PtcCO2 at 42°C was tested. The sensor was adapted to the ear of a neonate with a Varihesive layer (Conva Tec; Princeton, NJ). Data obtained from the ear sensor were compared with SpO2 Finger/Heel, SaO2, and PaCO2 obtained from arterial blood gas in 30 patients and with a capillary blood gas in an additional 30 patients using Bland Altman bias analysis. Data are presented as median (range). Results. The postconceptional age of the patients was 38.3 weeks (range: 28 5/7-40 5/7) in the arterial group and 37.9 weeks (range: 29 6/7-41 0/7) in the capillary group. Age of the newborns studied was 3.5 days (range: 1-28) in the arterial blood sample group (n = 30) and 6 days (range: 2-28) in the capillary blood sample group (n = 30). Patient weight was 3.02 kg (range: 1.5-4.5) in the arterial group and 2.76 kg (range: 1.0-3.71) in the other group. Three patients had weights of < 1500 g. Twenty-one of 60 patients were conventionally ventilated, 4 patients received high-freque- ncy oscillation, and 35 were not ventilated. Mean difference (bias) and precision (2 SD of the mean difference) between PtcCO2TOSCA and PaCO2 were -0.44 kPa (-3.21 mm Hg) and 0.82 kPa (6.02 mm Hg) and between PtcCO2TOSCA and PcapCO2 were -0.09 kPa (-0.67mm Hg) and 1.11 kPa (8.07 mm Hg), respectively. SpO2 assessment by the TOSCA revealed slightly higher values compared with SaO2 (bias: -0.48%), whereas SpO2Finger/Heel values were slightly lower than SaO2 (bias: 0.52%). Conclusion. The TOSCA monitor with the ear sensor adapted to ears of neonates allows reliable estimation of SaO2 and PaCO2. A potential benefit is the reduction in motion artifacts because of less head movement in new-borns and that onl y a single cable leads form the patient to the monitor. In addition, the sensor is not removed for chest radiograph or for nursing the infant on his or her parent’s lap. Long-term studies in a large population with continuous measurements are required to confirm these preliminary findings and to elucidate the benefits in detection of respiratory deterioration and the potential side effects of this sensor.
文摘In 127 infants admitted-to intensive care-for RSV bronchiolitis, concomitant bacterial sepsis was a rare even. However, in the subgroup of intubated patients the incidence of bacterial pneumonia was 43.9%(95%CI 31.0-56.8%), half community acquired and half nosocomial. As clinical signs are not helpful in identifying these patients, tracheal aspirates have to be investigated microbiologically on a routine basis in order to start antibiotics in time.
文摘In 127 infants admitted-to intensive care-for RSV bronchiolitis, concomitant bacterial sepsis was a rare even. However, in the subgroup of intubated patients the incidence of bacterial pneumonia was 43.9% (95% CI 31.0-56.8% ), half community acquired and half nosocomial. As clinical signs are not helpful in identifying these patients, tracheal aspirates have to be investigated microbiologically on a routine basis in order to start antibiotics in time.
