Objectives: To quantitatively assess improvement in acne scarring after a ser ies of nonablative laser treatments and to determine efficacy at 1- , 3- , and 6-month follow-up after treatment. Design: Before-after tria...Objectives: To quantitatively assess improvement in acne scarring after a ser ies of nonablative laser treatments and to determine efficacy at 1- , 3- , and 6-month follow-up after treatment. Design: Before-after trial of consecut ively selected patients. Setting: Private practice at the Laser and Skin Surgery Center of New York, New York. Patients: Eleven patients with mild to moderate a trophic acne scarring were treated. Interventions: A 3- dimensional optical pro filing imaging system was used to assess skin topography before, during, and aft er treatment. Patients were treated with a 1064- nm Q-switched Nd:YAG laser a nd reassessed after 3 treatment sessions and at 1, 3, and 6 months after the fif th treatment session. Main Outcome Measures: The skin roughness analysis was qua ntified at baseline and at each follow-up interval. Pain, erythema, and petech iae formation were assessed on 3-point scales. Results: At midtreatment (1 mon th after the third treatment session), an 8.9% improvement in roughness analys is was seen. This improvement increased to 23.3% , 31.6% , and 39.2% at 1, 3 , and 6 months after the fifth treatment, respectively. Patients reported mild t o moderate pain with treatment. The only adverse effects noted were transient er ythema and mild pinpoint petechiae. Conclusions: Treatment with the nonablative 1064-nm Q-switched Nd:YAG laser results in significant quantitative improvem ents in skin topography in patients with mild to moderate atrophic acne scars. C ontinued incremental improvements were noted at 1- , 3- , and 6-month follow -up, indicating ongoing dermal collagen remodeling after the treatment.展开更多
Background: The 1450-nm diode laser has been known to thermally alter sebaceous glands and has been found to be effective for the treatment of inflammatory facial acne. Objective:Our aim was to evaluate the dose respo...Background: The 1450-nm diode laser has been known to thermally alter sebaceous glands and has been found to be effective for the treatment of inflammatory facial acne. Objective:Our aim was to evaluate the dose response of a 1450-nmdiode laser for treatment of facial acne, sebum production, and acne scarring utilizing two laser fluences and to determine long-term remission after laser treatment. Methods: Twenty patients (Fitzpatrick skin phototypes II-VI) received 3 treatments using the 1450 nm diode laser (3- 4 week intervals).Split face comparisons were performed by randomizing patients to one of two fluences (14 or 16 J/cm2) on the right or left side of the face. Clinical photographs, lesion counts,and sebum measurements were obtained at baseline and after each treatment. Investigators’ and patients’ subjective evaluations of response to treatment were assessed. Results:Percentage reductions in mean acne lesion counts from baseline were 42.9% (14 J/cm2) and 33.9% (16 J/cm2) after one treatment and 75.1% (14 J/cm2) and 70.6% (16 J/cm2) after 3 treatments. There was persistent reduction of 76.1% (14 J/cm2) and 70.5% (16 J/cm2) at the 12-month follow up(P < .01). Both objective and subjective improvements in acne scarring and sebum production were noted. Treatment-related pain was well tolerated, and adverse effects were limited to transient erythema and edema at treatment sites. Limitations:This was a small study and comparison was limitedto two laser fluences. Conclusion: The 1450-nm diode laser reduced inflammatory facial acne lesions even in Fitzpatrickskin phototypes IV-VI with minimal side effects. Significant improvement in acne lesion counts were noted after the first treatment and was maintained 12 months after the third treatment,indicating significant long-term clinical remission after laser treatment.展开更多
文摘Objectives: To quantitatively assess improvement in acne scarring after a ser ies of nonablative laser treatments and to determine efficacy at 1- , 3- , and 6-month follow-up after treatment. Design: Before-after trial of consecut ively selected patients. Setting: Private practice at the Laser and Skin Surgery Center of New York, New York. Patients: Eleven patients with mild to moderate a trophic acne scarring were treated. Interventions: A 3- dimensional optical pro filing imaging system was used to assess skin topography before, during, and aft er treatment. Patients were treated with a 1064- nm Q-switched Nd:YAG laser a nd reassessed after 3 treatment sessions and at 1, 3, and 6 months after the fif th treatment session. Main Outcome Measures: The skin roughness analysis was qua ntified at baseline and at each follow-up interval. Pain, erythema, and petech iae formation were assessed on 3-point scales. Results: At midtreatment (1 mon th after the third treatment session), an 8.9% improvement in roughness analys is was seen. This improvement increased to 23.3% , 31.6% , and 39.2% at 1, 3 , and 6 months after the fifth treatment, respectively. Patients reported mild t o moderate pain with treatment. The only adverse effects noted were transient er ythema and mild pinpoint petechiae. Conclusions: Treatment with the nonablative 1064-nm Q-switched Nd:YAG laser results in significant quantitative improvem ents in skin topography in patients with mild to moderate atrophic acne scars. C ontinued incremental improvements were noted at 1- , 3- , and 6-month follow -up, indicating ongoing dermal collagen remodeling after the treatment.
文摘Background: The 1450-nm diode laser has been known to thermally alter sebaceous glands and has been found to be effective for the treatment of inflammatory facial acne. Objective:Our aim was to evaluate the dose response of a 1450-nmdiode laser for treatment of facial acne, sebum production, and acne scarring utilizing two laser fluences and to determine long-term remission after laser treatment. Methods: Twenty patients (Fitzpatrick skin phototypes II-VI) received 3 treatments using the 1450 nm diode laser (3- 4 week intervals).Split face comparisons were performed by randomizing patients to one of two fluences (14 or 16 J/cm2) on the right or left side of the face. Clinical photographs, lesion counts,and sebum measurements were obtained at baseline and after each treatment. Investigators’ and patients’ subjective evaluations of response to treatment were assessed. Results:Percentage reductions in mean acne lesion counts from baseline were 42.9% (14 J/cm2) and 33.9% (16 J/cm2) after one treatment and 75.1% (14 J/cm2) and 70.6% (16 J/cm2) after 3 treatments. There was persistent reduction of 76.1% (14 J/cm2) and 70.5% (16 J/cm2) at the 12-month follow up(P < .01). Both objective and subjective improvements in acne scarring and sebum production were noted. Treatment-related pain was well tolerated, and adverse effects were limited to transient erythema and edema at treatment sites. Limitations:This was a small study and comparison was limitedto two laser fluences. Conclusion: The 1450-nm diode laser reduced inflammatory facial acne lesions even in Fitzpatrickskin phototypes IV-VI with minimal side effects. Significant improvement in acne lesion counts were noted after the first treatment and was maintained 12 months after the third treatment,indicating significant long-term clinical remission after laser treatment.
