目的:随着对补体失调研究的深入,以C3沉积为主的肾小球肾炎日益受到关注,其病理类型多样,且病理类型间症状及预后差异具有异质性。为避免误诊及漏诊,本研究分析不同病理类型C3沉积为主的肾小球肾炎的临床、病理及预后特点。方法:回顾性...目的:随着对补体失调研究的深入,以C3沉积为主的肾小球肾炎日益受到关注,其病理类型多样,且病理类型间症状及预后差异具有异质性。为避免误诊及漏诊,本研究分析不同病理类型C3沉积为主的肾小球肾炎的临床、病理及预后特点。方法:回顾性分析52例2013年6月至2022年10月行肾活检诊断为以C3沉积为主肾小球肾炎患者的临床、病理及随访资料。根据临床表现以及病理检查结果分为感染后肾小球肾炎(post-infectious glomerulonephritis,PIGN)组(n=15)和非感染后肾小球肾炎(non-post-infectious glomerulonephritis,N-PIGN)组(n=37)。进一步行N-PIGN亚组分析,分为C3独立沉积组(n=16)与C3复合沉积组(n=21),或C3肾病(C3 glomerulopathy,C3G)组(n=27)与非C3肾病(N-C3G)组(n=10)。结果:PIGN组相较于N-PIGN组,活检时血清肌酐值更低(84.60μmol/L vs 179.62μmol/L,P=0.001),补体C3值更低(0.36 g/L vs 0.74 g/L,P<0.001),病理慢性化病变程度更轻。在N-PIGN亚组分析中,C3复合沉积组较C3独立沉积组血清肌酐值更高(235.30μmol/L vs 106.70μmol/L,P=0.004),24 h尿蛋白值更高(4025.62 mg vs 1981.11 mg,P=0.037)。PIGN组的预后好于N-PIGN组(P=0.049),C3独立沉积组的预后好于C3复合沉积组(P=0.017),C3G组的预后好于N-C3G(P=0.018)。结论:C3沉积为主的肾小球肾炎涵盖多种病理类型,诊断C3G前需先排除PIGN,但对于非典型PIGN患者仍需要警惕C3G叠加或者相互转化;此外,荧光显微镜下经典补体C1q的沉积可能提示肾预后不良,应加强相关诊治与随访。展开更多
目的探讨上海市浦东新区北蔡社区居民肺功能与体检指标之间的关系。方法选取2023年4月1日-2023年4月30日于上海市浦东新区北蔡社区卫生服务中心体检的老年居民发放COPD-PS问卷,问卷得分≥5分,自愿行肺功能检查人员为研究对象。比较肺功...目的探讨上海市浦东新区北蔡社区居民肺功能与体检指标之间的关系。方法选取2023年4月1日-2023年4月30日于上海市浦东新区北蔡社区卫生服务中心体检的老年居民发放COPD-PS问卷,问卷得分≥5分,自愿行肺功能检查人员为研究对象。比较肺功能正常与异常居民体检指标的关系、肺功能正常与慢阻肺患者体检指标关系。结果肺功能正常组与肺功能异常组空腹血糖[(5.8±1.0)mmol/L vs(7.3±2.8)mmol/L]、甘油三酯[(1.7±0.9)mmol/L vs(2.9±4.0)mmol/L]与甘油三酯葡萄糖乘积指数(triglyceride-glucose index,TyG指数)(8.8±0.6 vs 9.3±0.9)存在明显差异(均P<0.05),肺功能异常组拥有更高的空腹血糖、甘油三酯及TyG水平,其余指标(红细胞、白细胞、血红蛋白、血肌酐、肝功能、白蛋白、尿酸等)无统计学差异(P>0.05)。与肺功能正常组患者相比,慢阻肺患者拥有更高的甘油三酯[(1.7±0.9)mmol/L vs(3.7±5.7)mmol/L](P<0.01)、空腹血糖[(5.8±1.0)mmol/L vs(7.6±3.7)mmol/L](P<0.01)和TyG水平(8.8±0.6 vs 9.3±1.2)(P<0.05)。结论与肺功能正常居民相比,肺功能异常居民甘油三酯、空腹血糖、TyG水平较高;慢阻肺患者中甘油三酯、空腹血糖、TyG水平较高。展开更多
To investigate the seismic response of the steel-strip reinforced soil retaining wall with fullheight rigid facing in terms of the acceleration in the backfill, dynamic earth pressure in the backfill, the displacement...To investigate the seismic response of the steel-strip reinforced soil retaining wall with fullheight rigid facing in terms of the acceleration in the backfill, dynamic earth pressure in the backfill, the displacements on the facing and the dynamic reinforcement strain distribution under different peak acceleration, a large 1-g shaking table test was performed on a reduced-scale reinforced-earth retaining wall model. It was observed that the acceleration response in non-strip region is greater than that in potential fracture region which is similar with the stability region under small earthquake,while the acceleration response in potential fracture region is greater than that in stability region in middle-upper of the wall under moderately strong earthquakes. The potential failure model of the rigid wall is rotating around the wall toe. It also was discovered that the Fourier spectra produced by the inputting white noises after seismic wave presents double peaks, rather than original single peak, and the frequency of the second peak trends to increase with increasing the PGA(peak ground amplitude) of the excitation which is greater than 0.4 g. Additionally,the non-liner distribution of strip strain along the strips was observed, and the distribution trend was not constant in different row. Soil pressure peak value in stability region is larger than that in potential fracture region. The wall was effective under 0.1 g-0.3 g seismic wave according to the analyses of the facing displacement and relative density. Also, it was discovered that the potential failure surface is corresponds to that in design code, but the area is larger. The results from the study can provide guidance for a more rational design of reinforced earth retaining walls with full-height rigid facing in the earthquake zone.展开更多
文摘目的:随着对补体失调研究的深入,以C3沉积为主的肾小球肾炎日益受到关注,其病理类型多样,且病理类型间症状及预后差异具有异质性。为避免误诊及漏诊,本研究分析不同病理类型C3沉积为主的肾小球肾炎的临床、病理及预后特点。方法:回顾性分析52例2013年6月至2022年10月行肾活检诊断为以C3沉积为主肾小球肾炎患者的临床、病理及随访资料。根据临床表现以及病理检查结果分为感染后肾小球肾炎(post-infectious glomerulonephritis,PIGN)组(n=15)和非感染后肾小球肾炎(non-post-infectious glomerulonephritis,N-PIGN)组(n=37)。进一步行N-PIGN亚组分析,分为C3独立沉积组(n=16)与C3复合沉积组(n=21),或C3肾病(C3 glomerulopathy,C3G)组(n=27)与非C3肾病(N-C3G)组(n=10)。结果:PIGN组相较于N-PIGN组,活检时血清肌酐值更低(84.60μmol/L vs 179.62μmol/L,P=0.001),补体C3值更低(0.36 g/L vs 0.74 g/L,P<0.001),病理慢性化病变程度更轻。在N-PIGN亚组分析中,C3复合沉积组较C3独立沉积组血清肌酐值更高(235.30μmol/L vs 106.70μmol/L,P=0.004),24 h尿蛋白值更高(4025.62 mg vs 1981.11 mg,P=0.037)。PIGN组的预后好于N-PIGN组(P=0.049),C3独立沉积组的预后好于C3复合沉积组(P=0.017),C3G组的预后好于N-C3G(P=0.018)。结论:C3沉积为主的肾小球肾炎涵盖多种病理类型,诊断C3G前需先排除PIGN,但对于非典型PIGN患者仍需要警惕C3G叠加或者相互转化;此外,荧光显微镜下经典补体C1q的沉积可能提示肾预后不良,应加强相关诊治与随访。
文摘目的探讨上海市浦东新区北蔡社区居民肺功能与体检指标之间的关系。方法选取2023年4月1日-2023年4月30日于上海市浦东新区北蔡社区卫生服务中心体检的老年居民发放COPD-PS问卷,问卷得分≥5分,自愿行肺功能检查人员为研究对象。比较肺功能正常与异常居民体检指标的关系、肺功能正常与慢阻肺患者体检指标关系。结果肺功能正常组与肺功能异常组空腹血糖[(5.8±1.0)mmol/L vs(7.3±2.8)mmol/L]、甘油三酯[(1.7±0.9)mmol/L vs(2.9±4.0)mmol/L]与甘油三酯葡萄糖乘积指数(triglyceride-glucose index,TyG指数)(8.8±0.6 vs 9.3±0.9)存在明显差异(均P<0.05),肺功能异常组拥有更高的空腹血糖、甘油三酯及TyG水平,其余指标(红细胞、白细胞、血红蛋白、血肌酐、肝功能、白蛋白、尿酸等)无统计学差异(P>0.05)。与肺功能正常组患者相比,慢阻肺患者拥有更高的甘油三酯[(1.7±0.9)mmol/L vs(3.7±5.7)mmol/L](P<0.01)、空腹血糖[(5.8±1.0)mmol/L vs(7.6±3.7)mmol/L](P<0.01)和TyG水平(8.8±0.6 vs 9.3±1.2)(P<0.05)。结论与肺功能正常居民相比,肺功能异常居民甘油三酯、空腹血糖、TyG水平较高;慢阻肺患者中甘油三酯、空腹血糖、TyG水平较高。
基金founded by the National Natural Science Foundation of China(Grant No.51708163)Research Program of the Ministry of Transport of the People’s Republic of China(Grant No.2013318800020)Doctoral Innovation Fund Program of Southwest Jiaotong University(Grant No.D-CX201703)
文摘To investigate the seismic response of the steel-strip reinforced soil retaining wall with fullheight rigid facing in terms of the acceleration in the backfill, dynamic earth pressure in the backfill, the displacements on the facing and the dynamic reinforcement strain distribution under different peak acceleration, a large 1-g shaking table test was performed on a reduced-scale reinforced-earth retaining wall model. It was observed that the acceleration response in non-strip region is greater than that in potential fracture region which is similar with the stability region under small earthquake,while the acceleration response in potential fracture region is greater than that in stability region in middle-upper of the wall under moderately strong earthquakes. The potential failure model of the rigid wall is rotating around the wall toe. It also was discovered that the Fourier spectra produced by the inputting white noises after seismic wave presents double peaks, rather than original single peak, and the frequency of the second peak trends to increase with increasing the PGA(peak ground amplitude) of the excitation which is greater than 0.4 g. Additionally,the non-liner distribution of strip strain along the strips was observed, and the distribution trend was not constant in different row. Soil pressure peak value in stability region is larger than that in potential fracture region. The wall was effective under 0.1 g-0.3 g seismic wave according to the analyses of the facing displacement and relative density. Also, it was discovered that the potential failure surface is corresponds to that in design code, but the area is larger. The results from the study can provide guidance for a more rational design of reinforced earth retaining walls with full-height rigid facing in the earthquake zone.
