Objective: To investigate the correlation of second-trimester serum 25-OH-VitD3 with inflammatory factors and adipocytokines in patients with gestational diabetes mellitus. Methods: A total of 92 second-trimester preg...Objective: To investigate the correlation of second-trimester serum 25-OH-VitD3 with inflammatory factors and adipocytokines in patients with gestational diabetes mellitus. Methods: A total of 92 second-trimester pregnant women who were diagnosed with GDM in this hospital between December 2014 and January 2017 were selected as GDM group, and 80 healthy pregnant women who received antenatal care in this hospital during the same period were selected as normal control group. The serum levels of 25-OH-VitD3, inflammatory factors and adipocytokines were compared between the two groups of pregnant women, and Pearson test was used to evaluate the correlation of serum 25-OH-VitD3 level with inflammatory factors and adipocytokines in patients with GDM. Results: Serum 25-OH-VitD3 level of GDM group was lower than that of normal control group;serum inflammatory factors TNF-α, CRP and IL-6 levels were higher than those of normal control group while IL-10 level was lower than that of normal control group;serum adipocytokines RBP4 and VF levels were higher than those of normal control while APN level was lower than that of normal control group. Second-trimester serum 25-OH-VitD3 level of patients with GDM was directly correlated with the contents of inflammatory factors and adipocytokines. Conclusion: Second-trimester 25-OH-VitD3 deficiency in patients with GDM may be involved in the development of GDM through inflammatory factors and adipocytokines.展开更多
文摘Objective: To investigate the correlation of second-trimester serum 25-OH-VitD3 with inflammatory factors and adipocytokines in patients with gestational diabetes mellitus. Methods: A total of 92 second-trimester pregnant women who were diagnosed with GDM in this hospital between December 2014 and January 2017 were selected as GDM group, and 80 healthy pregnant women who received antenatal care in this hospital during the same period were selected as normal control group. The serum levels of 25-OH-VitD3, inflammatory factors and adipocytokines were compared between the two groups of pregnant women, and Pearson test was used to evaluate the correlation of serum 25-OH-VitD3 level with inflammatory factors and adipocytokines in patients with GDM. Results: Serum 25-OH-VitD3 level of GDM group was lower than that of normal control group;serum inflammatory factors TNF-α, CRP and IL-6 levels were higher than those of normal control group while IL-10 level was lower than that of normal control group;serum adipocytokines RBP4 and VF levels were higher than those of normal control while APN level was lower than that of normal control group. Second-trimester serum 25-OH-VitD3 level of patients with GDM was directly correlated with the contents of inflammatory factors and adipocytokines. Conclusion: Second-trimester 25-OH-VitD3 deficiency in patients with GDM may be involved in the development of GDM through inflammatory factors and adipocytokines.
