We report a general and highly efficient Mukaiyama-aldol reaction of ketones and difluoroenoxysilanes.While the reaction of aryl ketones worked efficiently in the presence of Bi(OTf)_3, that of aliphatic ketones requi...We report a general and highly efficient Mukaiyama-aldol reaction of ketones and difluoroenoxysilanes.While the reaction of aryl ketones worked efficiently in the presence of Bi(OTf)_3, that of aliphatic ketones required the use of Sc(OTf_)3. In addition, Sc(OTf)_3 was capable of achieving excellent 1,2-selectivity in the corresponding reaction of α,β-unsaturated ketones. This method provides a facile access to differently substituted β-hydroxy α,α-difluoro ketones, versatile synthons for difluomethylated tertiary alcohols.展开更多
基金supported by the National Basic Research Program of China (2015CB856600)the National Natural Science Foundation of China (21472049)
文摘We report a general and highly efficient Mukaiyama-aldol reaction of ketones and difluoroenoxysilanes.While the reaction of aryl ketones worked efficiently in the presence of Bi(OTf)_3, that of aliphatic ketones required the use of Sc(OTf_)3. In addition, Sc(OTf)_3 was capable of achieving excellent 1,2-selectivity in the corresponding reaction of α,β-unsaturated ketones. This method provides a facile access to differently substituted β-hydroxy α,α-difluoro ketones, versatile synthons for difluomethylated tertiary alcohols.
