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单细胞转录组测序在年龄相关性黄斑变性研究中的应用 被引量:4
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作者 安宁 张福燕 秦波 《国际眼科杂志》 CAS 北大核心 2022年第6期964-968,共5页
年龄相关性黄斑变性(ARMD)是临床中常见的老年性致盲性眼病,可造成中心视力的不可逆丧失,其发病机制复杂,尚未阐明,治疗方法有限,诊疗效果不佳。传统的转录组测序方法基于细胞群体水平获得细胞群的平均差异,或反映数量占优势细胞的生物... 年龄相关性黄斑变性(ARMD)是临床中常见的老年性致盲性眼病,可造成中心视力的不可逆丧失,其发病机制复杂,尚未阐明,治疗方法有限,诊疗效果不佳。传统的转录组测序方法基于细胞群体水平获得细胞群的平均差异,或反映数量占优势细胞的生物信息,而单细胞转录组测序(scRNA-seq)能对单个细胞的mRNA进行转录组分析,可用于发现新的细胞亚型、揭示细胞异质性、鉴定罕见细胞、理解细胞分化。本文简述了scRNA-seq的技术原理,及其在视网膜、脉络膜发育及ARMD研究中的应用,提出了该项技术的缺陷和新兴技术的发展趋势,为深入研究视网膜、脉络膜生理学、ARMD疾病病理生理学及其发病机制提供新的思路及视角,以期对ARMD的靶向治疗提供理论依据。 展开更多
关键词 单细胞 转录组测序 视网膜 年龄相关性黄斑变性
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Fast Approximate Geodesic Paths on Triangle Mesh 被引量:1
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作者 Jie Tang Gang-Shan Wu +1 位作者 fu-yan zhang Ming-Min zhang 《International Journal of Automation and computing》 EI 2007年第1期8-13,共6页
We present a new algorithm to compute a geodesic path over a triangle mesh. Based on Novotni's propagating wavefront method which is similar to the well known Dijkstra algorithm, we made some improvements which Novot... We present a new algorithm to compute a geodesic path over a triangle mesh. Based on Novotni's propagating wavefront method which is similar to the well known Dijkstra algorithm, we made some improvements which Novotni had missed and we also gave the method to find out the geodesic path which Novotni had not. It can handle both convex and non-convex surfaces or even with boundaries. Experiment results show that our method works very well both in efficiency and precision. 展开更多
关键词 Triangle mesh geodesic path virtual reality.
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Clinical analysis of bilateral acute depigmentation of the iris:first reported case in China
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作者 Ting Wang Wan-Man Wu +1 位作者 fu-yan zhang Xu Jia 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2022年第9期1560-1562,共3页
Dear Editor,We are writing this letter to present a rare case of bilateral acute depigmentation of the iris(BADI).The case of B ADI has not reported in China before,and this case report can help ophthalmologists to id... Dear Editor,We are writing this letter to present a rare case of bilateral acute depigmentation of the iris(BADI).The case of B ADI has not reported in China before,and this case report can help ophthalmologists to identify the clinical features of this disease. 展开更多
关键词 HAS features LETTER
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