In a recent study published in Life Metabolism,Xu et al.report that theα-ketoglutaric acid(AKG)/2-oxoglutarate receptor 1(OXGR1)signaling plays an important role in the regulation of sperm maturation by maintaining e...In a recent study published in Life Metabolism,Xu et al.report that theα-ketoglutaric acid(AKG)/2-oxoglutarate receptor 1(OXGR1)signaling plays an important role in the regulation of sperm maturation by maintaining epididymal fluid acid–base balance in epididymal smooth muscle cells,suggesting that AKG may provide a new chance for nutritional intervention of some male infertility.With the development of science and technology,the overall health conditions have been greatly improved,but the reproductive health issue is still challenging.Infertility is currently the third most common disease affecting human health,with~50%of cases being related to male infertility[1].展开更多
Infertility affects around 8%-12%of couples globally,and in about 50%of these cases,male factors are either the primary cause or contribute significantly to infertility.Any defects during spermiogenesis may result in ...Infertility affects around 8%-12%of couples globally,and in about 50%of these cases,male factors are either the primary cause or contribute significantly to infertility.Any defects during spermiogenesis may result in male subfertility or complete infertility in mammals.1 Previously,we found that CFAP53 is localized in the manchette and sperm tail,and it plays an essential role in sperm flagellum biogenesis.展开更多
文摘In a recent study published in Life Metabolism,Xu et al.report that theα-ketoglutaric acid(AKG)/2-oxoglutarate receptor 1(OXGR1)signaling plays an important role in the regulation of sperm maturation by maintaining epididymal fluid acid–base balance in epididymal smooth muscle cells,suggesting that AKG may provide a new chance for nutritional intervention of some male infertility.With the development of science and technology,the overall health conditions have been greatly improved,but the reproductive health issue is still challenging.Infertility is currently the third most common disease affecting human health,with~50%of cases being related to male infertility[1].
基金supported by the National Science Fund for Distinguished Young Scholars of China (No.81925015)the National Natural Science Foundation of China (No.91649202)+1 种基金the Shandong Provincial Key Research&Development Program (China) (No.2018YFJH0504)the open fund of the State Key Laboratory of Reproductive Medicine (China) (SKLRM-K202201).
文摘Infertility affects around 8%-12%of couples globally,and in about 50%of these cases,male factors are either the primary cause or contribute significantly to infertility.Any defects during spermiogenesis may result in male subfertility or complete infertility in mammals.1 Previously,we found that CFAP53 is localized in the manchette and sperm tail,and it plays an essential role in sperm flagellum biogenesis.
