Guided bone regeneration(G BR)membrane has been used to improve functional outcomes for periodontal regener ation.However,few studies have focused on the biomimetic membrane mim-icking the vascularization of the perio...Guided bone regeneration(G BR)membrane has been used to improve functional outcomes for periodontal regener ation.However,few studies have focused on the biomimetic membrane mim-icking the vascularization of the periodontal membrane.This study aimed to fabricate waterborne polyurethane(WPU)fibrous membranes loaJed fibroblast growth factor-2(FGF-2)via emulsion electrospinning,which can promote regeneration of periodontal tissue via the vascularization of the biomimetic GBR membrane.A biodegradable WPU was synthesized by using lysine and dime-thylpropionic acid as chain extenders according to the rule of green chemical synthesis technology.The WPU fibers with FGF-2 was fabricated via emulsion electrospinning.The results confirmed that controlled properties of the fibrous membrane had been achieved with controlled degradation,suitable mech anical properties and sustained release of the factor.The immunohistochemical expression of angiogenic-related factors was positive,meaning that FGF-2 loaded in fibers can sig-nificantly promote cell vasculariz ation.The fiber scaffold loaded FGF-2 has the potential to be used as a functional GBR membrane to promote the formation of extraosseous blood vessels during periodontal repairing.展开更多
AgNbO_(3) is an antiferroelectric (AFE) material with double hysteresis loop. Both the antiferroelectricityand ferroelectricity can be enhanced by doping. Herein, the ferroelectricity of AgNbO_(3) ceramics wasenhanced...AgNbO_(3) is an antiferroelectric (AFE) material with double hysteresis loop. Both the antiferroelectricityand ferroelectricity can be enhanced by doping. Herein, the ferroelectricity of AgNbO_(3) ceramics wasenhanced via K-doping and the phase diagram of the (Ag_(1-x)K_(x))NbO_(3) ceramics was upgraded. In details,(Ag_(1-x)K_(x))NbO_(3) ceramics are ferrielectric (FIE) M1 phase as x=5.00-5.50 mol% and ferroelectric (FE) Ophase as x=5.75-6.00 mol% before poling, and FE O phase as x=5.00-6.00 mol% after poling at roomtemperature. With increasing temperature, (Ag_(1-x)K_(x))NbO_(3) ceramics show the phase evolutions from FIEM1, AFE M2 to paraelectric (PE) T phase at x=5.00-5.50 mol% and from FE O, FE T to PE T phase at x=5.75-6.00 mol% before poling, and from FE O, FE T to PE T phase at x=5.00-6.00 mol% after poling.High d33 values of 180 pC/N and 285 pC/N are obtained at the FE O-FE T and FE T-PE T phase boundaries.This work sheds light on a novel and promising lead-free piezoelectric system.展开更多
基金This work was supported by the Doctoral Research Initiation Fund of Affiliated Hospital of Southwest Medical University,University Sponsored Research Program of Southwest Medical University(2019ZQN097)the National Natural Science Foundation(81802246).
文摘Guided bone regeneration(G BR)membrane has been used to improve functional outcomes for periodontal regener ation.However,few studies have focused on the biomimetic membrane mim-icking the vascularization of the periodontal membrane.This study aimed to fabricate waterborne polyurethane(WPU)fibrous membranes loaJed fibroblast growth factor-2(FGF-2)via emulsion electrospinning,which can promote regeneration of periodontal tissue via the vascularization of the biomimetic GBR membrane.A biodegradable WPU was synthesized by using lysine and dime-thylpropionic acid as chain extenders according to the rule of green chemical synthesis technology.The WPU fibers with FGF-2 was fabricated via emulsion electrospinning.The results confirmed that controlled properties of the fibrous membrane had been achieved with controlled degradation,suitable mech anical properties and sustained release of the factor.The immunohistochemical expression of angiogenic-related factors was positive,meaning that FGF-2 loaded in fibers can sig-nificantly promote cell vasculariz ation.The fiber scaffold loaded FGF-2 has the potential to be used as a functional GBR membrane to promote the formation of extraosseous blood vessels during periodontal repairing.
基金This work was supported by the National Natural Science Foun-dation of China(No.51802068 and No.52073144)the Natural Sci-ence Foundation of Hebei Province,China(No.E2021201044)+4 种基金the Advanced Talents Incubation Program of the Hebei University,China(No.801260201180)the Natural Science Foundation of Jiangsu Province,China(No.BK20201301)the State Key Laboratory of New Ceramic and Fine Processing Tsinghua University(No.KF202005 and No.KF202114)China Postdoctoral Science Foun-dation(No.2021M692491)Guangdong Basic and Applied Basic Research Foundation(No.2020A1515110251).
文摘AgNbO_(3) is an antiferroelectric (AFE) material with double hysteresis loop. Both the antiferroelectricityand ferroelectricity can be enhanced by doping. Herein, the ferroelectricity of AgNbO_(3) ceramics wasenhanced via K-doping and the phase diagram of the (Ag_(1-x)K_(x))NbO_(3) ceramics was upgraded. In details,(Ag_(1-x)K_(x))NbO_(3) ceramics are ferrielectric (FIE) M1 phase as x=5.00-5.50 mol% and ferroelectric (FE) Ophase as x=5.75-6.00 mol% before poling, and FE O phase as x=5.00-6.00 mol% after poling at roomtemperature. With increasing temperature, (Ag_(1-x)K_(x))NbO_(3) ceramics show the phase evolutions from FIEM1, AFE M2 to paraelectric (PE) T phase at x=5.00-5.50 mol% and from FE O, FE T to PE T phase at x=5.75-6.00 mol% before poling, and from FE O, FE T to PE T phase at x=5.00-6.00 mol% after poling.High d33 values of 180 pC/N and 285 pC/N are obtained at the FE O-FE T and FE T-PE T phase boundaries.This work sheds light on a novel and promising lead-free piezoelectric system.
