帕金森病患者的烟碱型乙酰胆碱受体广泛减少

Objective: Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects. Methods: Nicotinic acetylcholine receptors were imaged in 10 nondemented Parkinson’s disease patients and 15 age-matched healthy subjects using a single-photon emission computed tomography ligand [123I] 5- iodo- 3- [2(S)- 2- azetidinylmethoxy]pyridine. Using an arterial input function, we measured the total distribution volume (V; specific plus nondisplaceable), as well as the delivery (K1). Results: Parkinson’s disease showed a widespread significant decrease (approximately 10% ) of V in both cortical and subcortical regions without a significant change in K1. Interpretation: These results indicate the importance of extending the study to demented patients.

肾小管中血管紧张素受体相关蛋白增加可抑制血管紧张素依赖性高血压

先前研究者发现血管紧张素Ⅱ1型受体相关蛋白（angiotensin Ⅱ type 1 receptor—associated protein，ATRAP）与血管紧张素Ⅱ1型受体相互作用，促进受体大量向细胞内移动，从而抑制其下游通路信号的病理性激活，并同时保持基本生理性信号传递活性。该研究旨在探究肾脏ATRAP在血管紧张素Ⅱ依赖性高血压发生发展过程中的作用。方法：研究者建立主要在。肾小管，包括远端肾小管表达ATRAP的转基因小鼠模型。