Dear Editor,Lung cancer is the predominant cause of cancer-related deaths globally,with non-small cell lung cancer(NSCLC)accounting for 85%of all cases.1 The five-year overall survival(OS)after surgery remains poor be...Dear Editor,Lung cancer is the predominant cause of cancer-related deaths globally,with non-small cell lung cancer(NSCLC)accounting for 85%of all cases.1 The five-year overall survival(OS)after surgery remains poor because of the high rate of postoperative recurrence and metastasis.Recently,immune checkpoint inhibitors(ICIs)have shown promising efficacy in resectable NSCLC.展开更多
γδT cells are a conserved population of innate lymphocytes with diverse structural and functional heterogeneity that participate in various immune responses during tumor progression. γδT cells perform potent immun...γδT cells are a conserved population of innate lymphocytes with diverse structural and functional heterogeneity that participate in various immune responses during tumor progression. γδT cells perform potent immunosurveillance by exerting direct cytotoxicity, strong cytokine production and indirect antitumor immune responses. However, certain γδT-cell subsets also contribute to tumor progression by facilitating cancer-related inflammation and immunosuppression. Here, we review recent observations regarding the antitumor and protumor roles of major structural and functional subsets of human γδT cells, describing how these subsets are activated and polarized, and how these events relate to subsequent function in tumor immunity. These studies provide insights into the manipulation of γδT-cell function to facilitate more targeted approaches for tumor therapy.展开更多
基金supported by grants from the National Natural Science Foundation of China (81472640,81672802,82273268)the Zhejiang Provincial Natural Science Foundation of China (No.LZ17H160004)+2 种基金the Key R&D Program of Zhejiang (2022C03100)the Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talentsthe Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang (2019R01007).
文摘Dear Editor,Lung cancer is the predominant cause of cancer-related deaths globally,with non-small cell lung cancer(NSCLC)accounting for 85%of all cases.1 The five-year overall survival(OS)after surgery remains poor because of the high rate of postoperative recurrence and metastasis.Recently,immune checkpoint inhibitors(ICIs)have shown promising efficacy in resectable NSCLC.
文摘γδT cells are a conserved population of innate lymphocytes with diverse structural and functional heterogeneity that participate in various immune responses during tumor progression. γδT cells perform potent immunosurveillance by exerting direct cytotoxicity, strong cytokine production and indirect antitumor immune responses. However, certain γδT-cell subsets also contribute to tumor progression by facilitating cancer-related inflammation and immunosuppression. Here, we review recent observations regarding the antitumor and protumor roles of major structural and functional subsets of human γδT cells, describing how these subsets are activated and polarized, and how these events relate to subsequent function in tumor immunity. These studies provide insights into the manipulation of γδT-cell function to facilitate more targeted approaches for tumor therapy.
