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靶向对比剂CLT1-(Gd-DTPA)在小鼠乳腺癌磁共振分子成像效果的研究(英文) 被引量:5
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作者 furong ye Eun-Kee Jeong +1 位作者 Denis Parker Zheng-Rong Lu 《磁共振成像》 CAS 2011年第5期325-330,共6页
本文研究了一个小肽靶向的对比剂CLT1-(Gd-DTPA)对肿瘤基质中的纤维蛋白——链接纤维蛋白复和物的磁共振分子影像的效能。所用动物模型为带有MDA-MB-231乳腺癌的母系裸鼠,所用仪器为西门子3T磁共振成像仪,对比剂为Gd-(DTPA-BMA),所用CLT... 本文研究了一个小肽靶向的对比剂CLT1-(Gd-DTPA)对肿瘤基质中的纤维蛋白——链接纤维蛋白复和物的磁共振分子影像的效能。所用动物模型为带有MDA-MB-231乳腺癌的母系裸鼠,所用仪器为西门子3T磁共振成像仪,对比剂为Gd-(DTPA-BMA),所用CLT1-(Gd-DPTA)剂量为0.05mmol/kg。该对比剂特一性地结合到肿瘤并产生明显的对比增强,增强效果至少持续60分钟。相比之下,非特一性对比剂Gd(DTPA-BMA)很快从体内排除,30分钟后几乎无任何增强效果(0.1mmol/kg)。CLT1-(Gd-DTPA)在血液,肝和肌肉等正常组织中几乎无非特一性结合,其在正常组织中的增强效果和对比剂相当。此研究证明CLT1-(Gd-DTPA)对肿瘤的特一性及其在小鼠乳腺癌模型中的肿瘤增强效果。该靶向性对比剂可以用于乳腺癌的磁共振分子成像。 展开更多
关键词 磁共振成像 分子成像 对比剂 小鼠 乳腺癌
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The Application of Blended Learning Approach in EFL Teaching
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作者 furong ye 《Journal of Contemporary Educational Research》 2020年第5期19-22,共4页
Blended learning(BL)has been recognized as one of the most promising directions in education development in the modern world as it combines the strengths of traditional educational methods and benefits of online learn... Blended learning(BL)has been recognized as one of the most promising directions in education development in the modern world as it combines the strengths of traditional educational methods and benefits of online learning technologies.This paper starts with an exploration of BL as a concept,models and its application in language teaching and then probe into the effectiveness of BL approach in English as Foreign Language(EFL)Teaching especially to boost students speaking and listening competence,via a comparative study.With 50 in control group taught through traditional face-to-face instructions and 58 in experiment group through BL method,108 students are involved to find out that BL is conducive to promote students’motivation,self-study as well as activity and also to enhance their speaking and listening skills. 展开更多
关键词 Blended Learning EFL Teaching Pedagogical Experiment English Communication Competence
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