In this study the effect of collagen-polyvinylpyrrolidone (collagen- PVP) vs. triamcinolone acetonide (Triam) in scleroderma (SSc) skin lesions was evaluated. Ten SSc patients were treated weekly with subcutaneous inj...In this study the effect of collagen-polyvinylpyrrolidone (collagen- PVP) vs. triamcinolone acetonide (Triam) in scleroderma (SSc) skin lesions was evaluated. Ten SSc patients were treated weekly with subcutaneous injections of 0.2 mL Triam (8 mg/mL) or 0.2 mL collagen- PVP (1.66 mg collagen). Skin biopsies were obtained from lesions before and after treatment. Tissue sections were evaluated by histology and immunohistochemistry (ELAM-1, VCAM- 1, IL- 1β ,TNF-α ,TGF-β 1 and PDGF). The corticoid- treated group showed abnormal tissue architecture while the biodrug- treatment restored cutaneous appendages and type I/III collagen proportion. Cytokine and adhesion molecule expression was almost inhibited with Triam, while collagen-PVP down- regulated it. Collagen-PVP improved the tissue architecture of SSc lesions and down regulated some proinflammatory parameters, without the side effects induced by corticoids.展开更多
文摘In this study the effect of collagen-polyvinylpyrrolidone (collagen- PVP) vs. triamcinolone acetonide (Triam) in scleroderma (SSc) skin lesions was evaluated. Ten SSc patients were treated weekly with subcutaneous injections of 0.2 mL Triam (8 mg/mL) or 0.2 mL collagen- PVP (1.66 mg collagen). Skin biopsies were obtained from lesions before and after treatment. Tissue sections were evaluated by histology and immunohistochemistry (ELAM-1, VCAM- 1, IL- 1β ,TNF-α ,TGF-β 1 and PDGF). The corticoid- treated group showed abnormal tissue architecture while the biodrug- treatment restored cutaneous appendages and type I/III collagen proportion. Cytokine and adhesion molecule expression was almost inhibited with Triam, while collagen-PVP down- regulated it. Collagen-PVP improved the tissue architecture of SSc lesions and down regulated some proinflammatory parameters, without the side effects induced by corticoids.
