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1例3次挑战培美曲塞方案治疗晚期非小细胞肺癌有效的个案报道 被引量:10
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作者 程林林 高峨嵋 +3 位作者 朱富新 王玉艳 仲佳 安彤同 《中国肺癌杂志》 CAS CSCD 北大核心 2019年第6期395-400,共6页
非小细胞肺癌(non-small cell lung cancer, NSCLC)约占肺癌的85%,5年总生存率小于15%-19%,且80%以上的肺癌患者明确诊断时属于中晚期(Ⅲb期-Ⅳ期),以化疗为主的综合治疗是目前无驱动基因突变的晚期NSCLC的主要治疗方式。以培美曲塞为... 非小细胞肺癌(non-small cell lung cancer, NSCLC)约占肺癌的85%,5年总生存率小于15%-19%,且80%以上的肺癌患者明确诊断时属于中晚期(Ⅲb期-Ⅳ期),以化疗为主的综合治疗是目前无驱动基因突变的晚期NSCLC的主要治疗方式。以培美曲塞为基础的含铂两药方案及培美曲塞单药方案,分别是一线主要指南推荐方案及二线可选择方案,而三线及后线治疗无循证医学依据,根据患者既往用药情况选择后线治疗方案是临床常用的重要方法。培美曲塞是高效低毒的多靶点化疗药物,晚期NSCLC再挑战应用培美曲塞方案是一种合理的选择。本文报道1例三次挑战使用培美曲塞基础方案治疗晚期NSCLC有效的个案病例并做相关文献复习。 展开更多
关键词 肺肿瘤 培美曲塞 再次挑战 三次挑战
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Pneumonic benign metastasizing leiomyoma:a case report and clinical treatment
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作者 fuxin zhu Heng Sun Linlin Cheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第1期52-54,共3页
Benign metastasizing leiomyoma (BML) is a rare entity usually occuring in females with history of uterus leiomyoma. It appears as a histopathologic benign smooth muscle tumors, distant from the uterus. It is hormone... Benign metastasizing leiomyoma (BML) is a rare entity usually occuring in females with history of uterus leiomyoma. It appears as a histopathologic benign smooth muscle tumors, distant from the uterus. It is hormone dependent and progresses slowly. Operation is the main clinical treatment. The article was reported one case who was a thirty-eight years old female. She was found to have bilateral lung nodules after hysterectomy of uterine leiomyoma seven years ago. An open lung biopsy revealed that the nodules consist of proliferating smooth muscle cells with a histopathologic feature which was similar to her uterus leiomyoma. Positive staining of estrogen and progesterone receptors were detected, which proved the turner originate from utedne. The patient did not accept operation, chemotherapy, radiotherapy or other treatment. We still follow up the development of the case. 展开更多
关键词 UTERUS benign leiomyoma lung metastatic tumor HISTOPATHOLOGY
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