Aims: To evaluate cardiopulmonary exercise tolerance in a large cohort of appa rently healthy paediatric cancer survivors in order to determine their participa tion in sporting activities. Methods: A total of 84 young...Aims: To evaluate cardiopulmonary exercise tolerance in a large cohort of appa rently healthy paediatric cancer survivors in order to determine their participa tion in sporting activities. Methods: A total of 84 young (< 21 years) asy- mptomatic childhood cancer survivors, who had been exposed to anthracyclines ( mean dose 212 mg/m2) and/or chest irradiation (median dose 2000 cGy), with norma l left ventricular systolic function at rest (fractional shortening > 29%), and 79 healthy controls were studied. Exercise testing was performed on a treadmill ergometer. Gas exchange analysis and derived variables were measured on a breat h-by-breath basis. Pulmonary functional evaluation was performed before exerci se. Echocardiographic evaluation at rest was performed within one month before t he exercise test. Results: There were no differences in exercise responses betwe en patients and controls. In boys < 13 years, mean VO2 max was slightly but sign ificantly lower than in controls. This finding was thought to be a result of dec reased physical fitness as all the other exercise parameters were similar to those in the controls. Conclusions: Results show that apparently healthy survivors of paediatric cancer can take part in dynamic sporting activities if they exhibi t a normal response to cardiopulmonary exercise testing, while those that exhibi t a reduced VO2 max should be re-evaluated after an aerobic training programme, and should undergo tailored dynamic physical activity if the VO2 max does not n ormalise.展开更多
文摘Aims: To evaluate cardiopulmonary exercise tolerance in a large cohort of appa rently healthy paediatric cancer survivors in order to determine their participa tion in sporting activities. Methods: A total of 84 young (< 21 years) asy- mptomatic childhood cancer survivors, who had been exposed to anthracyclines ( mean dose 212 mg/m2) and/or chest irradiation (median dose 2000 cGy), with norma l left ventricular systolic function at rest (fractional shortening > 29%), and 79 healthy controls were studied. Exercise testing was performed on a treadmill ergometer. Gas exchange analysis and derived variables were measured on a breat h-by-breath basis. Pulmonary functional evaluation was performed before exerci se. Echocardiographic evaluation at rest was performed within one month before t he exercise test. Results: There were no differences in exercise responses betwe en patients and controls. In boys < 13 years, mean VO2 max was slightly but sign ificantly lower than in controls. This finding was thought to be a result of dec reased physical fitness as all the other exercise parameters were similar to those in the controls. Conclusions: Results show that apparently healthy survivors of paediatric cancer can take part in dynamic sporting activities if they exhibi t a normal response to cardiopulmonary exercise testing, while those that exhibi t a reduced VO2 max should be re-evaluated after an aerobic training programme, and should undergo tailored dynamic physical activity if the VO2 max does not n ormalise.
