The utilization of poly （2-hydroxyethylmetha- crylate） grafted agar （Ag-g-P（HEMA）） as a matrix for the controlled release of 5-aminosalicylic acid was investi- gated. Grafted copolymers of 2-hydroxyethylmethacry...The utilization of poly （2-hydroxyethylmetha- crylate） grafted agar （Ag-g-P（HEMA）） as a matrix for the controlled release of 5-aminosalicylic acid was investi- gated. Grafted copolymers of 2-hydroxyethylmethacrylate （HEMA） monomers on agar were synthesized by micro- wave assisted method. In vitro drug release studies were performed at pH values of 2 and 7 in order to investigate the possibility of pH triggered release for colon targeted drug delivery. Further, the percent grafting vs. tso （the time taken for release of 50% of the enclosed drug） value was studied and the results indicate that it may be possible to develop a programmable drug release matrix based on grafted polysaccharide. Ag-g-P（HEMA） appears to be a useful matrix for controlled release.展开更多
文摘The utilization of poly （2-hydroxyethylmetha- crylate） grafted agar （Ag-g-P（HEMA）） as a matrix for the controlled release of 5-aminosalicylic acid was investi- gated. Grafted copolymers of 2-hydroxyethylmethacrylate （HEMA） monomers on agar were synthesized by micro- wave assisted method. In vitro drug release studies were performed at pH values of 2 and 7 in order to investigate the possibility of pH triggered release for colon targeted drug delivery. Further, the percent grafting vs. tso （the time taken for release of 50% of the enclosed drug） value was studied and the results indicate that it may be possible to develop a programmable drug release matrix based on grafted polysaccharide. Ag-g-P（HEMA） appears to be a useful matrix for controlled release.
