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Clinical Safety of New Tri-Phasic Oral Contraceptive Pill
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作者 N.Mereuri G.Brilli +6 位作者 A.C.Mancini g.botticelli G.Fabbri A.D.Genazzani F.Petraglia A.Volpe A.R.Genazzani 《Journal of Reproduction and Contraception》 CAS 1991年第1期25-30,共6页
The aim of our study was to evaluate the metabolic and clinical effects of a contraceptive treatment with a new tri-phasic formulation of ethynyl-estradiol (35μg) and norethisterone (0.5-1mg) in fertile women.For thi... The aim of our study was to evaluate the metabolic and clinical effects of a contraceptive treatment with a new tri-phasic formulation of ethynyl-estradiol (35μg) and norethisterone (0.5-1mg) in fertile women.For this purpose 20 healthy fertile women (19-32years) volunteered to follow this trial.High-density lipoprotein cholesterol,low-density lipoprotion cholesterol,fibrinogen concentration and antithrombin Ⅲ were measured by enzymatic method and fibrinopeptides A,by RIA.The patients were treated for 6 cycles and they were studied before and after 1,3, and 6 cycles of treatment.In all patients both the length of the menstrual cycle,and bleeding,acne and seborrhea and side effects were evaluated.The contraceptive therapy with this new formulation resulted very effective,without significant metabolic changes and with very few side effects. 展开更多
关键词 三相口服避孕药丸 药物安全性 临床试验 药物代谢动力学 育龄女性
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