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血小板及其来源的细胞外囊泡在恶性肿瘤中的临床价值
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作者 陈悦 章洁洁 +3 位作者 方梦坤 肖梦琴 高广涛 许佩佩 《中国肿瘤》 CAS CSCD 北大核心 2023年第1期73-79,共7页
血小板的主要功能是参与止血、维持血管完整性、促进血栓形成。近年来,越来越多的研究证据显示,血小板在肿瘤的生长、增殖、侵袭、转移等过程中也发挥着关键作用。并且这些功能与血小板活化后释放的细胞外囊泡密切相关。血小板活化后释... 血小板的主要功能是参与止血、维持血管完整性、促进血栓形成。近年来,越来越多的研究证据显示,血小板在肿瘤的生长、增殖、侵袭、转移等过程中也发挥着关键作用。并且这些功能与血小板活化后释放的细胞外囊泡密切相关。血小板活化后释放的细胞外囊泡是一种非均匀的纳米级小泡,包括微粒和外泌体,均表现出原细胞的特性,可携带遗传物质(微小RNA、信使RNA等)、酶、蛋白质和小分子,介导细胞间物质转运的通讯。基于此,血小板与恶性肿瘤之间的相互作用,引起了研究者们的关注。全文就血小板及其来源的细胞外囊泡与恶性肿瘤的相关性研究进行综述,旨在揭示两者既能作为肿瘤的新型标志物的潜力,又能在肿瘤治疗领域发挥巨大的潜能。 展开更多
关键词 血小板 细胞外囊泡 外泌体 微粒 肿瘤
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Development and progress in polymer materials foranti-corrosion and anti-fouling applications:A review
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作者 LYU Ren-jiang WANG Nan +5 位作者 ZHANG Rui-yong gao guang-tao LI Sheng-xi DUAN Ji-zhou HOU Bao-rong SAND Wolfgang 《Journal of Central South University》 SCIE EI CAS 2024年第10期3547-3569,共23页
Corrosion has always been a difficult problem that troubles and restricts the application and development ofengineering materials.By endowing coatings on metal surfaces with polymer material,it is possible to protect ... Corrosion has always been a difficult problem that troubles and restricts the application and development ofengineering materials.By endowing coatings on metal surfaces with polymer material,it is possible to protect othermaterials from factors including acid and alkali,water vapor,bacteria.Therefore,it is necessary to summarize theresearch progress of polymer materials in the field of pollution and corrosion prevention in recent years.This articlesummarizes four types of polymer materials with good weather resistance:polyurethane(PU),polydimethylsiloxane(PDMS),polyvinylidene fluoride(PVDF),and polyvinylidene chloride(PVDC).These four polymer materials aresuitable for making polymer anti-corrosion or anti-fouling materials and each has its own characteristics.PU can firmlyadhere to various substrates,effectively protecting and extending their lifespan,but the environmentally friendly varietiescurrently used,namely water-borne polyurethanes(WPU),generally have poor mechanical properties.PDMS is nontoxicand has excellent hydrophobicity,but its static anti-fouling ability is insufficient when applied in the field of antifouling.PVDF has good chemical resistance and high mechanical properties,good UV resistance making it suitable foroutdoor use like in the marine environment.However,PVDF lacks flexibility after molding and its manufacturing cost isrelatively high.PVDC has excellent water vapor barrier properties,but poor adhesion to metal material surfaces.Therefore,researchers need to modify these four polymers when using them to solve the problem of corrosion orbiofouling.The article will review the research progress of four types of polymers in recent years from the perspectivesof anti-corrosion,anti-fouling,and a strategy named as self-healing that is beneficial for protecting polymer surfacesfrom mechanical damage,and summarize the modification methods adopted by researchers when applying thesematerials.Finally,a summary of the application and the prospects of these polymer materials are presented. 展开更多
关键词 anti-corrosion polymer corrosion anti-fouling self-healing
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