药品上市许可持有人药物警戒检查探讨--基于山东省药品不良反应报告和监测检查情况

2019年新修订的《药品管理法》明确国家建立药物警戒制度,国家药监局也陆续发布了《药物警戒质量管理规范》《药物警戒检查指导原则》等法规文件,为药品上市许可持有人落实药物警戒主体责任提供了明确的标准和操作指南。2020年,山东省依据《药品不良反应报告和监测管理办法》《药品不良反应报告和监测检查指南(试行)》等要求,对辖区51家药品上市许可持有人药品不良反应报告和监测工作情况进行了检查。本文通过对检查发现的问题、缺陷情况进行分析,探讨持有人在药品不良反应报告和监测工作基础上,开展药物警戒工作存在的主要问题和困难,提出推动持有人落实药物警戒主体责任、加强药物警戒工作的相关建议。

Synthesis and Properties of Novel Luminescent Compounds Containing Triphenylamine and Bipyridine Units

Blue luminescent compounds T1―T4 containing triphenylamine donors,bipyridine acceptors and olefinic linkers were synthesized and characterized by 1 H NMR,13 C NMR and high resolution mass spectrometry（HRMS）.Four compounds T1―T4 exhibit excellent solubility in common solvents and good film forming properties.Quantum chemical calculations show that compounds T1―T4 have asymmetric linear structures and the proper highest occupied molecular orbital（HOMO） levels.The UV-Vis absorption and fluorescence emission spectra of the four compounds in dilute chloroform solutions and on the solid films were measured.It reveals that compounds T1―T4 exhibit similar spectral behavior,suggesting that these compounds can form amorphous state in solid films.The calculated absorption and emission spectra of compounds T1―T4 are in good agreement with experimentally determined ones.Compounds T1―T4 have absolute fluorescence quantum yield above 17% in dilute chloroform solutions.Four compounds possess high glass-transition temperature（T g） exceeding 97 ℃ and the maximum T g is 155.28 ℃ for compound T3.Cyclic voltammetry measurements show that these compounds have proper HOMO levels in a range of-5.01―-5.13 eV for hole injection.The properties of compounds T1―T4 indicate that these compounds are candidates for the application in organic light-emitting devices（OLEDs） as hole-transporting materials（HTMs）.

基于游标细分容栅编码器的误差分析与研究

近年来,由于多领域对于容栅技术的研究,容栅编码器获得了广泛的应用。针对容栅编码器角度测量存在偏差、导致测量精度不够的问题。本文基于游标细分原理设计一款容栅编码器,通过分析误差来源及其优化方案,获得高质量、高精度的电信号,实现绝对角位移测量。