对杰弗瑞·帕克等人所著Platform Revolution:How Network Markets Are Transforming the Economy and How to Make Them Work for You一书进行了概念编码分析,构建了由“用户运营”“行业引领”“价值攫取”3个模块构成的平台型企...对杰弗瑞·帕克等人所著Platform Revolution:How Network Markets Are Transforming the Economy and How to Make Them Work for You一书进行了概念编码分析,构建了由“用户运营”“行业引领”“价值攫取”3个模块构成的平台型企业商业模式体系。研究发现:用户运营行为是平台型企业价值创造的基础条件,要求平台型企业通过持续不断的用户吸引、用户维系和用户拓展方式积累多元化用户资源价值;行业引领行为强化了平台型企业的价值转移能力,要求平台型企业通过技术创新、资源整合的方式争取行业领军地位以强化获利能力;价值攫取行为则有助于平台型企业实现商业价值的最终获取,要求平台型企业通过多边平台经营模式并设计合理的盈利机制,以互利共赢为约束条件,最终实现平台型企业价值可持续攫取的目标。本文所构建的模型体系,为指导我国平台型企业商业运作,推动互联网产业发展具有重要意义。展开更多
Background Hypoxemic respiratory failure （HRF） is one of the most common causes for neonatal infants requiring aggressive respiratory support. Inhaled nitric oxide （iNO） has been established routinely as an adjunc...Background Hypoxemic respiratory failure （HRF） is one of the most common causes for neonatal infants requiring aggressive respiratory support. Inhaled nitric oxide （iNO） has been established routinely as an adjunct to conventional respiratory support in developed countries. The aim of this study was to investigate effects of iNO in neonates with HRF in resource limited condition with no or limited use of surfactant, high frequency oscillatory ventilation （HFOV） and extracorporeal membrane oxygenation.Methods A non-randomized, open, controlled study of efficacy of iNO was conducted over 18 months. Eligible term and near-term neonates from 28 hospitals with HRF （oxygenation index ＞15） were enrolled prospectively into two groups as either iNO or control. Oxygenation improvement and mortality as primary endpoint were determined in relation with dosing and timing of iNO, severity of underlying diseases, complications and burden. Intention-to-treat principle was adopted for outcome assessment. Response to iNO at 10 or 20 parts per million （ppm） was determined by oxygenation in reference to the control （between-group） and the baseline （within-group）.Results Compared to 93 controls, initial dose of iNO at 10 ppm in 107 treated infants significantly improved oxygenation from first hour （P=0.046）, with more partial- and non-responders improved oxygenation with subsequent 20ppm NO （P=0.018）. This effect persisted on days 1 and 3, and resulted in relatively lower mortalities （11.2% vs. 15%）whereas fewer were treated with surfactant （10% vs. 27%）,HFOV （＜5%） or postnatal corticosteroids （＜10%） in both groups. The overall outcomes at 28 days of postnatal life in the iNO-treated was not related to perinatal asphyxia,underlying diseases, severity of hypoxemia, or complications,but to the early use of iNO. The cost of hospital stay was not significantly different in both groups.Conclusions With relatively limited use of surfactant and/or HFOV in neonatal HRF, significantly more responders were found in the iNO-treated patients as reflected by improved oxygenation in the first three days over the baseline level. It warrants a randomized, controlled trial for assessment of appropriate timing and long-term outcome of iNO.展开更多
文摘对杰弗瑞·帕克等人所著Platform Revolution:How Network Markets Are Transforming the Economy and How to Make Them Work for You一书进行了概念编码分析,构建了由“用户运营”“行业引领”“价值攫取”3个模块构成的平台型企业商业模式体系。研究发现:用户运营行为是平台型企业价值创造的基础条件,要求平台型企业通过持续不断的用户吸引、用户维系和用户拓展方式积累多元化用户资源价值;行业引领行为强化了平台型企业的价值转移能力,要求平台型企业通过技术创新、资源整合的方式争取行业领军地位以强化获利能力;价值攫取行为则有助于平台型企业实现商业价值的最终获取,要求平台型企业通过多边平台经营模式并设计合理的盈利机制,以互利共赢为约束条件,最终实现平台型企业价值可持续攫取的目标。本文所构建的模型体系,为指导我国平台型企业商业运作,推动互联网产业发展具有重要意义。
文摘Background Hypoxemic respiratory failure （HRF） is one of the most common causes for neonatal infants requiring aggressive respiratory support. Inhaled nitric oxide （iNO） has been established routinely as an adjunct to conventional respiratory support in developed countries. The aim of this study was to investigate effects of iNO in neonates with HRF in resource limited condition with no or limited use of surfactant, high frequency oscillatory ventilation （HFOV） and extracorporeal membrane oxygenation.Methods A non-randomized, open, controlled study of efficacy of iNO was conducted over 18 months. Eligible term and near-term neonates from 28 hospitals with HRF （oxygenation index ＞15） were enrolled prospectively into two groups as either iNO or control. Oxygenation improvement and mortality as primary endpoint were determined in relation with dosing and timing of iNO, severity of underlying diseases, complications and burden. Intention-to-treat principle was adopted for outcome assessment. Response to iNO at 10 or 20 parts per million （ppm） was determined by oxygenation in reference to the control （between-group） and the baseline （within-group）.Results Compared to 93 controls, initial dose of iNO at 10 ppm in 107 treated infants significantly improved oxygenation from first hour （P=0.046）, with more partial- and non-responders improved oxygenation with subsequent 20ppm NO （P=0.018）. This effect persisted on days 1 and 3, and resulted in relatively lower mortalities （11.2% vs. 15%）whereas fewer were treated with surfactant （10% vs. 27%）,HFOV （＜5%） or postnatal corticosteroids （＜10%） in both groups. The overall outcomes at 28 days of postnatal life in the iNO-treated was not related to perinatal asphyxia,underlying diseases, severity of hypoxemia, or complications,but to the early use of iNO. The cost of hospital stay was not significantly different in both groups.Conclusions With relatively limited use of surfactant and/or HFOV in neonatal HRF, significantly more responders were found in the iNO-treated patients as reflected by improved oxygenation in the first three days over the baseline level. It warrants a randomized, controlled trial for assessment of appropriate timing and long-term outcome of iNO.
