Objective:To evaluate the clinical efficacy of acupuncture in the treatment of anxiety state in patients with primary insomnia(PI).Methods:Randomized controlled trials of acupuncture treatment for PI patients with an ...Objective:To evaluate the clinical efficacy of acupuncture in the treatment of anxiety state in patients with primary insomnia(PI).Methods:Randomized controlled trials of acupuncture treatment for PI patients with an anxiety state in Web of Science,Cochrane Library,PubMed,Excerpta Medica Database(EMBASE),China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service Platform(Wanfang),and Chongqing VIP Database(VIP)were retrieved by computer.The retrieval time was from each database’s inception to December 30,2022.Data extraction and evaluation were performed for the included studies.The Cochrane risk of bias assessment tool was used to assess the risk of bias in each article.Meta-analysis of valid data was performed using the RevMan 5.4 software.If the outcome indicator was a categorical variable,relative risk(RR)was used as the effect size.If it was a continuous variable,mean difference(MD)was used to calculate the effect size.Each effect size was expressed as a 95%confidence interval(CI).P<0.05 was considered to indicate a statistically significant difference.Results:A total of 18 studies were included,comprising a total of 1198 patients.The findings of the meta-analysis showed that electroacupuncture had a significant advantage in improving the Hamilton anxiety scale(HAMA)score than benzodiazepines[MD=-1.61,95%CI(-2.17,-1.06),P<0.001].Acupuncture was superior to sham acupuncture[MD=-14.90,95%CI(-20.39,-9.41),P<0.001]and benzodiazepines[MD=-3.39,95%CI(-4.67,-2.12),P<0.001]in reducing the self-rating anxiety scale(SAS)score.Acupuncture was superior to sham acupuncture in reducing the insomnia severity index(ISI)score[MD=-5.61,95%CI(-6.63,-4.89),P<0.001].Acupuncture was superior to benzodiazepines[MD=0.84,95%CI(-1.42,-0.25),P=0.005]and sham acupuncture[MD=-8.39,95%CI(-8.39,-7.86),P<0.001]in improving the Pittsburgh sleep quality index(PSQI)score.Acupuncture had a better effective rate than benzodiazepines[RR=1.16,95%CI(1.08,1.25),P<0.001]and sham acupuncture[RR=8.94,95%CI(4.63,17.25),P<0.001]in treating PI.Conclusion:Acupuncture or electroacupuncture has certain therapeutic advantages over benzodiazepines and sham acupuncture in the treatment of anxiety in PI patients.However,more high-quality randomized controlled trials are needed for further verification.展开更多
以二苯甲酮-4,4′-二甲酸(BDA)为共聚单体,通过缩合聚合制备了一系列具有不同组成的聚(二苯甲酮-4,4′-二甲酸/己二酸癸二醇酯)(PDBA)高分子光引发剂。核磁共振氢谱(1 H NMR)及差示扫描量热分析(DSC)结果显示,当BDA摩尔含量不大于30%时,...以二苯甲酮-4,4′-二甲酸(BDA)为共聚单体,通过缩合聚合制备了一系列具有不同组成的聚(二苯甲酮-4,4′-二甲酸/己二酸癸二醇酯)(PDBA)高分子光引发剂。核磁共振氢谱(1 H NMR)及差示扫描量热分析(DSC)结果显示,当BDA摩尔含量不大于30%时,PDBA的熔点随着BDA含量的增加而降低,且其值介于45.6~77.4℃之间。核磁共振氢谱、红外吸收光谱(FTIR)和凝胶渗透色谱(GPC)证明产物为主链含二苯甲酮基这一光引发基团共聚酯。紫外吸收光谱显示,BDA摩尔含量20%的共聚物PDBA-20与二苯甲酮(BP)具有类似的紫外吸收行为,而其迁移率显著低于BP。在引发聚乙二醇二丙烯酸酯(PEGDA)紫外固化和超高分子量聚乙烯(UHMWPE)紫外交联时,PDBA-20表现出与BP基本相似的引发活性。展开更多
文摘Objective:To evaluate the clinical efficacy of acupuncture in the treatment of anxiety state in patients with primary insomnia(PI).Methods:Randomized controlled trials of acupuncture treatment for PI patients with an anxiety state in Web of Science,Cochrane Library,PubMed,Excerpta Medica Database(EMBASE),China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service Platform(Wanfang),and Chongqing VIP Database(VIP)were retrieved by computer.The retrieval time was from each database’s inception to December 30,2022.Data extraction and evaluation were performed for the included studies.The Cochrane risk of bias assessment tool was used to assess the risk of bias in each article.Meta-analysis of valid data was performed using the RevMan 5.4 software.If the outcome indicator was a categorical variable,relative risk(RR)was used as the effect size.If it was a continuous variable,mean difference(MD)was used to calculate the effect size.Each effect size was expressed as a 95%confidence interval(CI).P<0.05 was considered to indicate a statistically significant difference.Results:A total of 18 studies were included,comprising a total of 1198 patients.The findings of the meta-analysis showed that electroacupuncture had a significant advantage in improving the Hamilton anxiety scale(HAMA)score than benzodiazepines[MD=-1.61,95%CI(-2.17,-1.06),P<0.001].Acupuncture was superior to sham acupuncture[MD=-14.90,95%CI(-20.39,-9.41),P<0.001]and benzodiazepines[MD=-3.39,95%CI(-4.67,-2.12),P<0.001]in reducing the self-rating anxiety scale(SAS)score.Acupuncture was superior to sham acupuncture in reducing the insomnia severity index(ISI)score[MD=-5.61,95%CI(-6.63,-4.89),P<0.001].Acupuncture was superior to benzodiazepines[MD=0.84,95%CI(-1.42,-0.25),P=0.005]and sham acupuncture[MD=-8.39,95%CI(-8.39,-7.86),P<0.001]in improving the Pittsburgh sleep quality index(PSQI)score.Acupuncture had a better effective rate than benzodiazepines[RR=1.16,95%CI(1.08,1.25),P<0.001]and sham acupuncture[RR=8.94,95%CI(4.63,17.25),P<0.001]in treating PI.Conclusion:Acupuncture or electroacupuncture has certain therapeutic advantages over benzodiazepines and sham acupuncture in the treatment of anxiety in PI patients.However,more high-quality randomized controlled trials are needed for further verification.
文摘以二苯甲酮-4,4′-二甲酸(BDA)为共聚单体,通过缩合聚合制备了一系列具有不同组成的聚(二苯甲酮-4,4′-二甲酸/己二酸癸二醇酯)(PDBA)高分子光引发剂。核磁共振氢谱(1 H NMR)及差示扫描量热分析(DSC)结果显示,当BDA摩尔含量不大于30%时,PDBA的熔点随着BDA含量的增加而降低,且其值介于45.6~77.4℃之间。核磁共振氢谱、红外吸收光谱(FTIR)和凝胶渗透色谱(GPC)证明产物为主链含二苯甲酮基这一光引发基团共聚酯。紫外吸收光谱显示,BDA摩尔含量20%的共聚物PDBA-20与二苯甲酮(BP)具有类似的紫外吸收行为,而其迁移率显著低于BP。在引发聚乙二醇二丙烯酸酯(PEGDA)紫外固化和超高分子量聚乙烯(UHMWPE)紫外交联时,PDBA-20表现出与BP基本相似的引发活性。
