Performance Improvement of Polyvinyl Formal Based Gel Polymer Electrolyte for Lithium-Ion Batteries by Coating Al2O3

Al2O3/PVFM/Al2O3 trilayer membranes are prepared by means of simple coating of PVA-Al2O3 solution onto both sides of PVFM thin membranes, which is prepared via phase inversion method. The characteristics of the trilayer membranes and gel polymer electrolytes are investigated using FESEM, tensile testing apparatus, thermal shrinkage test, EIS and charge-discharge test. When inorganic Al2O3 particles are used to coat the PVFM membrane, drawbacks associated with gel-type membranes, namely, poor mechanical strength and thermal stability are greatly improved. Lithium ion cell with the Al2O3/PVFM/Al2O3 based GPE matched with LiFePO4 shows excellent electrochemical performance.

Identification of tumor-suppressor genes in lung squamous cell carcinoma through integrated bioinformatics analyses

Lung cancer is a prevalent malignancy,and fatalities of the disease exceed 400,000 cases worldwide.Lung squamous cell carcinoma(LUSC)has been recognized as the most common pathological form of lung cancer.The comprehensive understanding of molecular features related to LUSC progression has great significance in LUSC prognosis assessment and clinical management.In this study,we aim to identify a panel of signature genes closely associated with LUSC,which can provide novel insights into the progression of LUSC.Gene expression profiles were retrieved from public resources including gene expression omnibus(GEO)and the cancer genome atlas(TCGA)database.Differentially expressed genes(DEGs)between LUSC specimens and normal lung tissues were identified by bioinformatics analyses.A total of 66 DEGs were identified based on two cohorts of data.CytoHubba plugin of Cytoscape software was utilized for the further analyses of the top 10 candidate hub genes including OGN,ABI3BP,MAMDC2,FGF7,FAM107A,SPARCL1,DCN,COL14A1,and MFAP4 and CHRDL1,which showed significant downregulation in LUSC.Two LUSC cell lines were used to validate the functions of CHRDL1 and FAM107A through overexpression experiment.Together,our data revealed novel candidate tumor-suppressor genes in LUSC,suggesting previously unappreciated mechanisms in the progression of LUSC.

食管鳞癌患者根治性放疗预后列线图模型的构建—泛京津冀多中心回顾分析(3JECROG R-03A)

目的:构建列线图(nomogram)模型以预测食管鳞癌患者的预后情况,指导个体化治疗。方法:回顾性分析2002年1月至2016年12月国内10家放疗中心(泛京津冀食管癌协作组-3JECROG)收治的2680例根治性放疗食管鳞癌患者资料,随机分为训练组和验证组,根据训练组的预后因素构建nomogram模型,并进行训练组内部和验证组外部验证。分别以nomogram模型与AJCC/UICC分期评估两组患者预后及临床获益。结果:全组1、3、5年生存率分别为69.0%、37.7%、31.0%。多因素分析肿瘤部位、TNM分期、原发肿瘤体积和是否同步化疗是影响食管癌的独立预后因素(均P<0.05)。在训练组和验证组中nomogram模型的一致性指数(C-index)、AUC值均高于AJCC/UICC分期(均P<0.001)。基于nomogram模型分为低、中、高风险亚组与AJCC/UICC分期比较,nomogram模型的生存曲线之间具有显著性差异(P<0.001),且1、3、5年的总生存临床决策曲线(decision curve analysis,DCA)下面积均具有显著性差异。结论:本研究构建的nomogram模型较AJCC/UICC分期具有更好的预测能力,有助于食管癌患者的预后判断及指导个体化治疗。

Static Force-Based Modeling and Parameter Estimation for a Deformable Link Composed of Passive Spherical Joints With Preload Forces

To balance the contradiction between higher flexibility and heavier load bearing capacity,we present a novel deformable manipulator which is composed of active rigid joints and deformable links.The deformable link is composed of passive spherical joints with preload forces between socket-ball surfaces.To estimate the load bearing capacity of a deformable link,we present a static force-based model of spherical joint with preload force and analyze the static force propagation in the deformable link.This yields an important result that the load bearing capacity of a spherical joint only depends on its radius,preload force,and static friction coefficient.We further develop a parameter estimation method to estimate the product of preload force and static friction coefficient.The experimental results validate our model.80.4%of percentage errors on the maximum payload mass prediction are below 15%.

Mapping QTL underlying tuber starch content and plant maturity in tetraploid potato

Tuber starch content and plant maturity are two important agronomic traits of potato. To investigate the complex genetic basis of these traits in the cultivated potato, as well as the relationship between them, we developed a linkage map in a tetraploid population of 192 clones derived from the cross Longshu 8 × Zaodabai and mapped quantitative trait loci(QTL) for tuber starch content and plant maturity using data collected in three diverse environments over two years. We detected eleven QTL for tuber starch content distributed on seven chromosomes, of which four, on chromosomes I, II, and VIII, were expressed in at least three environments. For plant maturity, we identified six QTL on chromosomes II, IV,V, VII, and XI, one of which, on chromosome V, showed LOD peaks ranging from 45.2 to 62.5 cM and explained 21.6%–26.6% of phenotypic variation was expressed in five of the six environments. Because the reproducible QTL for plant maturity and tuber starch content mapped to different chromosomes and neither overlapping QTL, nor any genetic interaction between QTL were detected, we infer that tuber starch content and plant maturity are controlled by independent genetic loci. This inference supports the prospect of breeding potato for both early maturity and high starch content.

Survivin反义寡核苷酸对宣威肺腺癌细胞凋亡的影响(英文)

Objective:The aim of the study was to investigate the effects of Survivin antioligonucleotide on the proliferation,apoptosis and cell cycle of Xuanwei lung adenocarcinoma cell XWLC-05.Methods:Specific targeting Survivin ASODN was composed firstly.XWLC-05 would be divided into 4 groups:Group Sham(blank),Group Lip(simple liposome),Group Lip-SODN(transfected sense oligonucleotide) and Group Lip-ASODN(transfected ASODN).All groups had been transfected under the same condition for 48 hours.Then West blotting was used to check the expression of Survivin in cells from different groups and flow cytometer was used to find out the apoptosis rate of cells in different groups.Results:The expression of XWLC-05 Survivin in Group Lip-ASODN decreased obviously and apoptosis rate was significantly higher than that of other groups(P < 0.05).Conclusion:XWLC-05 transfected by Survivin ASODN could down regulate the expression of Survivin and lower expression of Survivin might lead to the apoptosis of XWLC-05 and restrain the proliferation of cancer cells.

Synergistic effects of compound physical factor treatment on neurological outcome after peripheral nerve entrapment surgery A randomized controlled study

BACKGROUND： Iatrophysics can improve the velocity of local microcirculation at peripheral nerve injured sites and promote the recovery from injury. Research has shown that simultaneous application of two physical factors has synergistic effects on the recovery of peripheral nerve function. OBJECTIVE： To treat patients that received peripheral nerve entrapment surgery with comprehensive rehabilitation by decimeter wave therapy and electrical stimulation, and to observe the clinical effects of promoting nerve function recovery. DESIGN： Randomized controlled study. SETTINGS： Department of Orthopaedics, the Third Hospital of Baoding; Department of Hand Surgery, the Third Hospital of Hebei Medical University; Woman-Children Healthcare Center, Southern District, Baoding. PARTICIPANTS： A total of 124 patients, who received peripheral nerve entrapment surgery, were selected from the Department of Orthopaedics, the Third Hospital of Baoding between July 2001 and May 2007. All patients met the diagnostic standard of peripheral nerve entrapment syndrome defined by Doctor Chen in 1995. All subjects gave informed consent for treatments and conditions involved. The experiment was approved by a local ethics committee. All patients were randomly divided into four groups： electrical stimulation group, decimeter wave group, compound physical factor group, and control group, with 31 subjects in each group. METHODS： Patients received neurolysis at an appropriate interval after hospitalization. （1） Multi-form wave therapeutic equipment made in China was used to treat patients in the electrical stimulation group after neurolysis. Wave form, stimulus width, interval time, and stimulus intensity were regulated based on the grade of nerve injury. The details were as follows： mild nerve injury： 50-100-ms stimulus width and 1 500-2 000-ms intervals; moderate nerve injury： 100-200-ms stimulus width and 3 000-4 000-ms intervals; severe nerve injury： 200-300-ms stimulus width and 3 000--6 000-ms intervals. Current dosage was 20- 40 mA. The electrical stimulation was given 6 minutes/session, once a day, and 20 days were regarded as one treatment cycle. （2） A TMA-A double-frequent mild-hot therapeutic instrument was used on patients in the decimeter wave group after neurolysis. The therapeutic program was adapted to the early and middle-late phase. In the early phase, the decimeter wave was 10-15 W, 10 minutes/session, once a day; in the middle-late phase, the decimeter wave was 10-30 W, 20 minutes/session, once a day. Twenty days were regarded as one treatment cycle. （3） Patients in the compound physical factor group following neurolysis were treated the same as the decimeter wave group and electrical stimulation group, respectively. The treatment was performed once a day, and 20 days were regarded as one course. （4） Patients in the control group were not administered any physical treatment. MAIN OUTCOME MEASURES： Therapeutic efficacy was comprehensively evaluated based on motor and sensory evaluation criteria （set by Subassociation of Hand Surgery, Chinese Medical Association） at 1, 2, and 3 months after surgery, as well as changes in the electromyogram before and after operation. RESULTS： All 124 patients with peripheral nerve entrapment syndrome were included in the final analysis. One month after surgery, fineness rates in the electrical stimulation group, decimeter wave group, and compound physical factor group were not significantly different from those in the control group （P 〉 0.05）. There was also no significant difference between the electrical stimulation group, decimeter wave group, and compound physical factor group （P 〉 0.05）. Two months after surgery, fineness rates in the electrical stimulation group and decimeter wave group were not significantly different from the control group （P 〉 0.05）. However, fineness rates were higher in the compound physical factor group compared to the other three groups （P 〈 0.05）. There was no significant difference between the electrical stimulation group and the decimeter wave group （P 〉 0.05）. Three months after operation, fineness rates in the electrical stimulation group, decimeter wave group, and compound physical factor group were higher than the control group （P 〈 0.05）. However, there was no significant difference between the electrical stimulation group, decimeter wave group, and compound physical factor group （P 〉 0.05）. CONCLUSION： The combination of decimeter wave therapy and electrical stimulation can remarkably shorten the recovery time of peripheral nerve function. The synergistic effect is superior to that of electrical stimulation and decimeter wave alone. This suggests that those two physical factors have synergistic effects on the treatment of peripheral nerve entrapment syndrome.

电视辅助胸腔镜在胸部肿瘤外科中的应用(英文)

Objective:The purpose of this study was to summarize and discuss the application of video-assisted thoracoscopic surgery(VATS) in the treatment of 58 chest cancers.Methods:The clinical data of 58 patients with thoracic tumor were analyzed retrospectively in treatment with VATS from July 2005 to June 2007.The surgery treatments included pulmonary wedge resection,enucleation of esophageal leiomyoma,bronchogenic cyst excision,mediastinal cyst excision,etc.Results:All patients were treated with VATS.Three patients of those with lung cancer underwent open-chest lobectomy resection.All patients had no death and few complications,and all discharged.Conclusion:VATS has advantages of less trauma,suffering light,quick recovery and small postoperative complications and has a great advantage in the treatment of chest benign tumors.But in the treatment of chest malignant tumors we should strictly control indications.

宣威昆明两地肺腺癌患者中生存素表达的比较研究(英文)

Objective: The aim of our study was to investigate the expression of Survivin in lung adenocarcinoma of Xuanwei and Kunming patients. Methods: Twenty-five specimens of Xuanwei patients and 28 specimens of Kunming patients were observed and analyzed. The Survivin expression was detected by immunohistochemistry. The results were quantitatively analyzed by image analysis system. Results: There were significant differences in Survivin expression (P < 0.01) between Xuanwei patients and Kunming patients. Conclusion: Survivin expression in lung adenocarcinoma of Xuanwei patients was significantly higher than that of Kunming patients. The pathogenesis of lung adenocarcinoma might be different between Xuanwei patients and Kunming patients. High Survivin expression might be one of the reasons to explain high incidence of lung cancer in Xuanwei.

Survivin-ASODN靶向治疗XWLC-50细胞移植瘤裸鼠的实验研究(英文)

Objective:The aim of this study was to study the inhibiting effect of survivin mRNA on transplanted XWLC-05 tumor on nude mice.Methods:We established XWLC-05 transplanted nude mice model.44 mice would be divided randomly into 4 groups:control group (blank),Lip group (simple liposome),survivin SODN group (transfected by sense oligonucleotide) and survivin ASODN group (transfected by antisense oligonucleotide).We would study general activities of nude mice in these 4 groups,measure the size of tumor and calculate the tumor inhabiting rate also.Pathological methods were applied in the analysis of the effect of different treatment on heart,kidney and liver of nude mice in these 4 groups.Results:Tumor grew slowly and size,weight of tumor was lower in survivin ASODN group when compared with that of others.Nude mice of survivin ASODN group showed lower growth index and tumor inhabiting rate was significantly higher than that of other groups (P < 0.05).Transplanted tumor on nude mice in control group (blank),Lip group,and survivin SODN group grew bigger as time passed and there was no significance among them (P > 0.05).We found a great deal of tumor cell necrosis in survivin ASODN group.No death of nude mice was observed in all 4 groups and we did not found obvious lesion in vital organs.Conclusion:Survivin ASDON could be used for the inhibitation of subcutaneously transplanted tumor in nude mice without obvious lesion in vital organs.