目的探究尤瑞克林联合阿司匹林对老年缺血性脑卒中病人血清中神经元特异性烯醇化酶(neutron specific enolase,NSE)和单核细胞趋化蛋白-1(monocyte chemotactic protein 1,MCP-1)水平的影响。方法我院于2013年5月至2015年5月期间收治的5...目的探究尤瑞克林联合阿司匹林对老年缺血性脑卒中病人血清中神经元特异性烯醇化酶(neutron specific enolase,NSE)和单核细胞趋化蛋白-1(monocyte chemotactic protein 1,MCP-1)水平的影响。方法我院于2013年5月至2015年5月期间收治的56例老年缺血性脑卒中病人,按随机数字表法分为对照组(28例)和观察组(28例)。所有病人治疗前均进行常规治疗,对照组口服阿司匹林,观察组在对照组的基础上,静脉滴注尤瑞克林。治疗15 d后观察病人的临床疗效及不良反应发生情况,对其进行美国国立卫生研究院脑卒中量表(National Institute of Health Stroke Scale,NIHSS)评分并检测其NSE和MCP-1水平。结果对照组临床有效率为71.4%,观察组为92.8%,观察组临床疗效显著优于对照组(P<0.05);治疗后2组NIHSS评分及血清NSE、MCP-1水平均明显降低,且观察组显著低于对照组(P<0.05);2组不良反应发生率差异无统计学意义(P>0.05)。结论尤瑞克林联合阿司匹林治疗老年缺血性脑卒中病人疗效显著,能降低血清NSE和MCP-1水平,改善神经功能,具有重要的临床应用价值。展开更多
目的探讨炎症小体NLR家族含CARD结构蛋白4(NLR family CARD domain-containing protein 4,NLRC4)的表达与急性脑梗死(acute cerebral infarction,ACI)之间的关系。方法选取2019年5月—2020年8月就诊于徐州医科大学附属淮海医院神经内科...目的探讨炎症小体NLR家族含CARD结构蛋白4(NLR family CARD domain-containing protein 4,NLRC4)的表达与急性脑梗死(acute cerebral infarction,ACI)之间的关系。方法选取2019年5月—2020年8月就诊于徐州医科大学附属淮海医院神经内科的39例ACI患者作为研究组,另选取同期于我院进行健康体检的40例患者作为对照组。酶联免疫吸附法检测患者及大鼠外周血中NLRC4、白介素-1β(IL-1β)及白介素-18(IL-18)的表达水平。通过阻断大鼠大脑中动脉血流24 h构建大鼠ACI动物模型,使用蛋白免疫印迹实验、组织切片免疫荧光染色实验评估缺血损伤对大鼠脑组织中NLRC4表达的影响。结果与对照组相比,研究组患者在年龄、体质量指数、性别构成、糖尿病以及吸烟情况方面差异无统计学意义(P>0.05),而高血压患者比例增高(P<0.05);血生化检查项目中,研究组患者外周血中C-反应蛋白水平较对照组显著升高(P<0.05),而高密度脂蛋白水平低于对照组(P<0.05);研究组患者外周血中NLRC4、IL-1β的表达较对照组显著升高(P<0.05)。蛋白免疫印迹实验结果显示NLRC4在缺血损伤大鼠脑组织中表达上调,差异有统计学意义(P<0.05);组织切片免疫荧光染色结果显示NLRC4在缺血损伤的神经元细胞中表达升高;ELISA结果显示NLRC4、IL-1β及IL-18在ACI大鼠外周血中的表达水平较对照组显著升高(P<0.05)。结论NLRC4及其介导的炎症小体信号在ACI脑组织中显著上调,具有作为新型ACI治疗靶点的潜力。展开更多
The problem of active vibration control for uncertain linear structural systems with control forces input timedelay is investigated in this study.First,the original structural equation is converted to a state-space mo...The problem of active vibration control for uncertain linear structural systems with control forces input timedelay is investigated in this study.First,the original structural equation is converted to a state-space model by utilizing the matrix transformation.Second,according to the obtained model and a special Lyapunov functional,a sufficient condition is achieved for the closed-loop system to be stable with a prescribed level of disturbance attenuation.Then,in terms of solving these linear matrix inequalities(LMIs),the state-feed controller is achieved to stabilize the structural system with the performance ‖z‖2<γ‖ω‖2.Third,by introducing the rank-1 vector to describe the system uncertainties,the uncertain system description is obtained,and the stabilizing condition is extended to the uncertain case.Finally,examples are given to show the effectiveness of the proposed methods.展开更多
The vacuum ultraviolet absorption and emission spectra of rare-gas vander Waals molecules were observed.A large broadening of at least 240Åof Xe first resonance absorption line was obtained at cell presgure 4 atm...The vacuum ultraviolet absorption and emission spectra of rare-gas vander Waals molecules were observed.A large broadening of at least 240Åof Xe first resonance absorption line was obtained at cell presgure 4 atm.Strong continuous emission of heavier rare gases at 1300-3000Åwas obtained using self-triggered condensed discharge in aπ-shaped quartz discharge tube.展开更多
The research on microfluidic droplet size prediction has been extensive and fruitful, while the droplet deforming process has been seldom studied. In this paper, a frying-oil-assessing microfluidic device was designed...The research on microfluidic droplet size prediction has been extensive and fruitful, while the droplet deforming process has been seldom studied. In this paper, a frying-oil-assessing microfluidic device was designed to study the droplet deforming and recovering processes, which were dominated by channel geometry, flow rates,sheath flow viscosity and interfacial tension of the two phases. Theoretical expressions of the deforming process and its extreme value were obtained for the first time, supported by simulation and experiments. Theoretical,simulation and experimental results indicated that the steady-state droplet length could be a useful parameter for frying oil assessment.展开更多
文摘目的探究尤瑞克林联合阿司匹林对老年缺血性脑卒中病人血清中神经元特异性烯醇化酶(neutron specific enolase,NSE)和单核细胞趋化蛋白-1(monocyte chemotactic protein 1,MCP-1)水平的影响。方法我院于2013年5月至2015年5月期间收治的56例老年缺血性脑卒中病人,按随机数字表法分为对照组(28例)和观察组(28例)。所有病人治疗前均进行常规治疗,对照组口服阿司匹林,观察组在对照组的基础上,静脉滴注尤瑞克林。治疗15 d后观察病人的临床疗效及不良反应发生情况,对其进行美国国立卫生研究院脑卒中量表(National Institute of Health Stroke Scale,NIHSS)评分并检测其NSE和MCP-1水平。结果对照组临床有效率为71.4%,观察组为92.8%,观察组临床疗效显著优于对照组(P<0.05);治疗后2组NIHSS评分及血清NSE、MCP-1水平均明显降低,且观察组显著低于对照组(P<0.05);2组不良反应发生率差异无统计学意义(P>0.05)。结论尤瑞克林联合阿司匹林治疗老年缺血性脑卒中病人疗效显著,能降低血清NSE和MCP-1水平,改善神经功能,具有重要的临床应用价值。
文摘目的探讨炎症小体NLR家族含CARD结构蛋白4(NLR family CARD domain-containing protein 4,NLRC4)的表达与急性脑梗死(acute cerebral infarction,ACI)之间的关系。方法选取2019年5月—2020年8月就诊于徐州医科大学附属淮海医院神经内科的39例ACI患者作为研究组,另选取同期于我院进行健康体检的40例患者作为对照组。酶联免疫吸附法检测患者及大鼠外周血中NLRC4、白介素-1β(IL-1β)及白介素-18(IL-18)的表达水平。通过阻断大鼠大脑中动脉血流24 h构建大鼠ACI动物模型,使用蛋白免疫印迹实验、组织切片免疫荧光染色实验评估缺血损伤对大鼠脑组织中NLRC4表达的影响。结果与对照组相比,研究组患者在年龄、体质量指数、性别构成、糖尿病以及吸烟情况方面差异无统计学意义(P>0.05),而高血压患者比例增高(P<0.05);血生化检查项目中,研究组患者外周血中C-反应蛋白水平较对照组显著升高(P<0.05),而高密度脂蛋白水平低于对照组(P<0.05);研究组患者外周血中NLRC4、IL-1β的表达较对照组显著升高(P<0.05)。蛋白免疫印迹实验结果显示NLRC4在缺血损伤大鼠脑组织中表达上调,差异有统计学意义(P<0.05);组织切片免疫荧光染色结果显示NLRC4在缺血损伤的神经元细胞中表达升高;ELISA结果显示NLRC4、IL-1β及IL-18在ACI大鼠外周血中的表达水平较对照组显著升高(P<0.05)。结论NLRC4及其介导的炎症小体信号在ACI脑组织中显著上调,具有作为新型ACI治疗靶点的潜力。
基金National Natural Science Foundation under Grant No.61305019&51365017Jiangxi Provincial Natural Science Foundation under Grant No.GJJ13430&GJJ13385the Natural Science Foundation of Jiangxi University of Science and Technology of China under Grant No.NSFJ2014-K16
文摘The problem of active vibration control for uncertain linear structural systems with control forces input timedelay is investigated in this study.First,the original structural equation is converted to a state-space model by utilizing the matrix transformation.Second,according to the obtained model and a special Lyapunov functional,a sufficient condition is achieved for the closed-loop system to be stable with a prescribed level of disturbance attenuation.Then,in terms of solving these linear matrix inequalities(LMIs),the state-feed controller is achieved to stabilize the structural system with the performance ‖z‖2<γ‖ω‖2.Third,by introducing the rank-1 vector to describe the system uncertainties,the uncertain system description is obtained,and the stabilizing condition is extended to the uncertain case.Finally,examples are given to show the effectiveness of the proposed methods.
文摘The vacuum ultraviolet absorption and emission spectra of rare-gas vander Waals molecules were observed.A large broadening of at least 240Åof Xe first resonance absorption line was obtained at cell presgure 4 atm.Strong continuous emission of heavier rare gases at 1300-3000Åwas obtained using self-triggered condensed discharge in aπ-shaped quartz discharge tube.
基金the National Natural Science Foundation of China(No.51205245)Innovation Program of Shanghai Municipal Education Commission(No.14ZZ092)+1 种基金Shanghai Municipal Natural Science Foundation(No.15ZR1415800)College Students’Joint Operation of Shanghai University(No.201618)
文摘The research on microfluidic droplet size prediction has been extensive and fruitful, while the droplet deforming process has been seldom studied. In this paper, a frying-oil-assessing microfluidic device was designed to study the droplet deforming and recovering processes, which were dominated by channel geometry, flow rates,sheath flow viscosity and interfacial tension of the two phases. Theoretical expressions of the deforming process and its extreme value were obtained for the first time, supported by simulation and experiments. Theoretical,simulation and experimental results indicated that the steady-state droplet length could be a useful parameter for frying oil assessment.