为了认识痕量元素As在飞灰中的富集特性,利用密度泛函理论研究了砷的典型氧化物AsO在飞灰中的主要成分SiO_2模型上的吸附机理,对优化后的吸附构型进行能量计算、AIM理论、Mulliken电荷分析以及定域化轨道指示函数(LOL)填色图分析,剖析了...为了认识痕量元素As在飞灰中的富集特性,利用密度泛函理论研究了砷的典型氧化物AsO在飞灰中的主要成分SiO_2模型上的吸附机理,对优化后的吸附构型进行能量计算、AIM理论、Mulliken电荷分析以及定域化轨道指示函数(LOL)填色图分析,剖析了AsO与SiO_2表面的相互作用。结果表明,AsO在无定型SiO_2表面的缺陷位的吸附能均大于50 k J/mol,吸附构型均为典型的化学吸附。在无定型SiO_2缺陷活性位点形成的As-Si键、Si-O键和As-O键强度较大,均属于共价键;SiO_2与AsO之间为共价相互作用。展开更多
According to the investigated data of Jiaozhou Bay in April, August, September and October of 1989, distribution, source and seasonal change of HCH in Jiaozhou Bay were analyzed. Results showed that HCH content change...According to the investigated data of Jiaozhou Bay in April, August, September and October of 1989, distribution, source and seasonal change of HCH in Jiaozhou Bay were analyzed. Results showed that HCH content changed during 0.012 7 -0.069 8 gg/L in Jiaozhou Bay and was very low. Seen from HCH content, water in Jiaozhou Bay was cleaner, and HCH did not have seasonal change. Horizontal distribution of HCH showed that HCH was directly input into offshore water only by surface runoff, and there was no river input. HCH was area source and was from land. In Jiaozhou Bay, the maximum HCH was gradually becoming smaller, and input manner also changed. HCH migration changed from river input to river and surface runoff input to final surface runoff input.展开更多
Sophorae Flavescentis Radix(SFR)is a medicinal herb with many functions that are involved in anti-inflammation,antinociception,and anticancer.SFR is also used to treat a variety of itching diseases.Matrine(MT)is one o...Sophorae Flavescentis Radix(SFR)is a medicinal herb with many functions that are involved in anti-inflammation,antinociception,and anticancer.SFR is also used to treat a variety of itching diseases.Matrine(MT)is one of the main constituents in SFR and also has the effect of relieving itching,but the antipruritic mechanism is still unclear.Here,we investigated the effect of MT on antipruritus.In acute and chronic itch models,MT significantly inhibited the scratching behavior not only in acute itching induced by histamine(His),chloroquine(CQ)and compound 48/80 with a dose-depended manner,but also in the chronic pruritus models of Atopic dermatitis(AD)and Acetone-ether-water(AEW)in mice.Furthermore,MT can be detected in the blood after intraperitoneal injection(i.p.)and subcutaneous injection(s.c.).Finally,electrophysiological and calcium image results show that MT inhibits the excitatory synaptic transmission from dorsal root ganglion(DRG)to the dorsal horn of the spinal cord by suppressing presynaptic N-type calcium channels.Taken together,we believe that MT is a novel drug candidate in treating pruritus diseases,especially for histamine-independent and chronic pruritus,which might be attributed to inhibition of presynaptic N-type calcium channels.展开更多
文摘为了认识痕量元素As在飞灰中的富集特性,利用密度泛函理论研究了砷的典型氧化物AsO在飞灰中的主要成分SiO_2模型上的吸附机理,对优化后的吸附构型进行能量计算、AIM理论、Mulliken电荷分析以及定域化轨道指示函数(LOL)填色图分析,剖析了AsO与SiO_2表面的相互作用。结果表明,AsO在无定型SiO_2表面的缺陷位的吸附能均大于50 k J/mol,吸附构型均为典型的化学吸附。在无定型SiO_2缺陷活性位点形成的As-Si键、Si-O键和As-O键强度较大,均属于共价键;SiO_2与AsO之间为共价相互作用。
基金Supported by Science Research Special Item of Marine Public Service Sectors,China(201205012,201305012)Science Research Fund of Director in North China Sea Environmental Monitoring Center of State Oceanic Administration,China(05EMC16)
文摘According to the investigated data of Jiaozhou Bay in April, August, September and October of 1989, distribution, source and seasonal change of HCH in Jiaozhou Bay were analyzed. Results showed that HCH content changed during 0.012 7 -0.069 8 gg/L in Jiaozhou Bay and was very low. Seen from HCH content, water in Jiaozhou Bay was cleaner, and HCH did not have seasonal change. Horizontal distribution of HCH showed that HCH was directly input into offshore water only by surface runoff, and there was no river input. HCH was area source and was from land. In Jiaozhou Bay, the maximum HCH was gradually becoming smaller, and input manner also changed. HCH migration changed from river input to river and surface runoff input to final surface runoff input.
文摘Sophorae Flavescentis Radix(SFR)is a medicinal herb with many functions that are involved in anti-inflammation,antinociception,and anticancer.SFR is also used to treat a variety of itching diseases.Matrine(MT)is one of the main constituents in SFR and also has the effect of relieving itching,but the antipruritic mechanism is still unclear.Here,we investigated the effect of MT on antipruritus.In acute and chronic itch models,MT significantly inhibited the scratching behavior not only in acute itching induced by histamine(His),chloroquine(CQ)and compound 48/80 with a dose-depended manner,but also in the chronic pruritus models of Atopic dermatitis(AD)and Acetone-ether-water(AEW)in mice.Furthermore,MT can be detected in the blood after intraperitoneal injection(i.p.)and subcutaneous injection(s.c.).Finally,electrophysiological and calcium image results show that MT inhibits the excitatory synaptic transmission from dorsal root ganglion(DRG)to the dorsal horn of the spinal cord by suppressing presynaptic N-type calcium channels.Taken together,we believe that MT is a novel drug candidate in treating pruritus diseases,especially for histamine-independent and chronic pruritus,which might be attributed to inhibition of presynaptic N-type calcium channels.
