Adiponectin,a specific hormone protein secreted by adipocytes,is a protective factor in the human body and has attracted great attention due to its anti-obesity activity[1,2].The adiponectin gene(ADIPOQ),which is loca...Adiponectin,a specific hormone protein secreted by adipocytes,is a protective factor in the human body and has attracted great attention due to its anti-obesity activity[1,2].The adiponectin gene(ADIPOQ),which is located on human chromosome 3q27,is a single-copy gene.Various single-nucleotide polymorphisms(SNPs)of the human ADIPOQ play an important role in energy balance and are associated with body mass index(BMI)and obesity[3,4].Longchain polyunsaturated fatty acids(LC-PUFAs)have been identified to exert an important role during the first 1,000 days of life on infant growth,neurodevelopment,and visual acuity.Fatty acids,such asα-linoleic acid(ALA,C18:3n-3)and linoleic acid(LA,C18:2n-6),which cannot be synthesized de novo from other lipids,are necessary for biological reactions.Some fatty acids such as docosahexaenoic acid(DHA,C22:6n-3)and eicosapentaenoic acid(EPA,C20:5n-3)can be synthesized in neonates from their precursors(LA and ALA).Because of the very low conversion rates in the neonatal liver,it is crucial to provide adequate LC-PUFAs in the diet from early infancy.展开更多
文摘Adiponectin,a specific hormone protein secreted by adipocytes,is a protective factor in the human body and has attracted great attention due to its anti-obesity activity[1,2].The adiponectin gene(ADIPOQ),which is located on human chromosome 3q27,is a single-copy gene.Various single-nucleotide polymorphisms(SNPs)of the human ADIPOQ play an important role in energy balance and are associated with body mass index(BMI)and obesity[3,4].Longchain polyunsaturated fatty acids(LC-PUFAs)have been identified to exert an important role during the first 1,000 days of life on infant growth,neurodevelopment,and visual acuity.Fatty acids,such asα-linoleic acid(ALA,C18:3n-3)and linoleic acid(LA,C18:2n-6),which cannot be synthesized de novo from other lipids,are necessary for biological reactions.Some fatty acids such as docosahexaenoic acid(DHA,C22:6n-3)and eicosapentaenoic acid(EPA,C20:5n-3)can be synthesized in neonates from their precursors(LA and ALA).Because of the very low conversion rates in the neonatal liver,it is crucial to provide adequate LC-PUFAs in the diet from early infancy.
