目的:观察加味六君子汤联合二甲双胍治疗2型糖尿病脾虚湿盛证患者的临床疗效及其对胰岛功能和脂代谢的影响。方法:本研究以2020年6月—2023年3月收治的90例2型糖尿病脾虚湿盛证患者为研究对象,随机分为二甲双胍治疗组(对照组)45例和加...目的:观察加味六君子汤联合二甲双胍治疗2型糖尿病脾虚湿盛证患者的临床疗效及其对胰岛功能和脂代谢的影响。方法:本研究以2020年6月—2023年3月收治的90例2型糖尿病脾虚湿盛证患者为研究对象,随机分为二甲双胍治疗组(对照组)45例和加味六君子汤联合二甲双胍治疗组(观察组)45例,两组均连续用药3个月评定疗效,治疗前、治疗3个月后进行中医脾虚湿盛证候积分评定,检测血糖(FPG、2 h PG、HbA1c)、胰岛功能(FINS、HOMA-IR、HOMA-β)和血脂(TC、TG、LDL)指标。结果:治疗3个月后,观察组显效率明显高于对照组(P<0.05);两组患者脾虚湿盛证候积分较治疗前均降低(P均<0.05),两组患者FPG、2 h PG、HbA1c、FINS、HOMA-IR、TC、TG、LDL均降低P均(<0.05),HOMA-β升高(P均<0.05);观察组脾虚湿盛证候积分及血糖、胰岛功能、血脂指标改善较对照组明显(P均<0.05)。结论:加味六君子汤联合二甲双胍治疗2型糖尿病脾虚湿盛证患者可有效降低血糖水平,改善胰岛功能和脂代谢,效果肯定。展开更多
To enhance the oil and gas recovery rate, hydraulic fracturing techniques have been widely adopted for stimulation of low-permeability reservoirs. Pioneering work indicates that hydraulic perforation and layout could ...To enhance the oil and gas recovery rate, hydraulic fracturing techniques have been widely adopted for stimulation of low-permeability reservoirs. Pioneering work indicates that hydraulic perforation and layout could significantly affect fracture initiation and propagation in low-permeability reservoir rocks subjected to complex in-situ stresses. This paper reports on a novel numerical method that incorporates fracture mechanics principles and the numerical tools FRANC3D and ANSYS to investigate the three-dimensional initiation and propagation behavior of hydro-fracturing cracks in shale rock. Considering the transverse isotropic property of shale rocks, the mechanical parameters of reservoir rocks attained from laboratory tests were adopted in the simulation. The influence of perforation layouts on the 3D initiation of hydro-fracturing fractures in reservoir rocks under geo-stresses was quantitatively illuminated. The propagation and growth of fractures in three dimensions in different perforating azimuth values were illustrated. The results indicate that： 1） the optimal perforation direction should be parallel to the maximum horizontal principal stress, 2） the crack plane gradually turns toward the direction of the maximum horizontal principal stress when they are not in parallel, 3） compared with the linear and symmetric pattern, the staggered perforation is the optimal one, 4） the proper perforation density is four to six holes per meter, 5） the optimal perforation diameter in this model is 30 ram, and 6） the influence of the perforation depth on the fracture initiation pressure is low.展开更多
文摘目的:观察加味六君子汤联合二甲双胍治疗2型糖尿病脾虚湿盛证患者的临床疗效及其对胰岛功能和脂代谢的影响。方法:本研究以2020年6月—2023年3月收治的90例2型糖尿病脾虚湿盛证患者为研究对象,随机分为二甲双胍治疗组(对照组)45例和加味六君子汤联合二甲双胍治疗组(观察组)45例,两组均连续用药3个月评定疗效,治疗前、治疗3个月后进行中医脾虚湿盛证候积分评定,检测血糖(FPG、2 h PG、HbA1c)、胰岛功能(FINS、HOMA-IR、HOMA-β)和血脂(TC、TG、LDL)指标。结果:治疗3个月后,观察组显效率明显高于对照组(P<0.05);两组患者脾虚湿盛证候积分较治疗前均降低(P均<0.05),两组患者FPG、2 h PG、HbA1c、FINS、HOMA-IR、TC、TG、LDL均降低P均(<0.05),HOMA-β升高(P均<0.05);观察组脾虚湿盛证候积分及血糖、胰岛功能、血脂指标改善较对照组明显(P均<0.05)。结论:加味六君子汤联合二甲双胍治疗2型糖尿病脾虚湿盛证患者可有效降低血糖水平,改善胰岛功能和脂代谢,效果肯定。
基金supported by the National Natural Science Foundation for Distinguished Young Scholars of China(Grant No.51125017)the National Natural Science Foundation of China(Grant No.51374213)+2 种基金the Fund for Creative Research and Development Group Program of Jiangsu Province(2014)the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(Grant No.51421003)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
文摘To enhance the oil and gas recovery rate, hydraulic fracturing techniques have been widely adopted for stimulation of low-permeability reservoirs. Pioneering work indicates that hydraulic perforation and layout could significantly affect fracture initiation and propagation in low-permeability reservoir rocks subjected to complex in-situ stresses. This paper reports on a novel numerical method that incorporates fracture mechanics principles and the numerical tools FRANC3D and ANSYS to investigate the three-dimensional initiation and propagation behavior of hydro-fracturing cracks in shale rock. Considering the transverse isotropic property of shale rocks, the mechanical parameters of reservoir rocks attained from laboratory tests were adopted in the simulation. The influence of perforation layouts on the 3D initiation of hydro-fracturing fractures in reservoir rocks under geo-stresses was quantitatively illuminated. The propagation and growth of fractures in three dimensions in different perforating azimuth values were illustrated. The results indicate that： 1） the optimal perforation direction should be parallel to the maximum horizontal principal stress, 2） the crack plane gradually turns toward the direction of the maximum horizontal principal stress when they are not in parallel, 3） compared with the linear and symmetric pattern, the staggered perforation is the optimal one, 4） the proper perforation density is four to six holes per meter, 5） the optimal perforation diameter in this model is 30 ram, and 6） the influence of the perforation depth on the fracture initiation pressure is low.
