OBJECTIVE Scalp mechanical stimulation, like combing, is one of the useful methods to keep brain health, which was historically recorded in traditional Chinese medicine thousand years ago. For the brain care, it is co...OBJECTIVE Scalp mechanical stimulation, like combing, is one of the useful methods to keep brain health, which was historically recorded in traditional Chinese medicine thousand years ago. For the brain care, it is considered to promote cerebrovascular circulation to prevent alopecia,headache, neurasthenia, insomnia, memory deficits. However, few study was reported on its effect and how the scalp mechanical stimulation works on vascular functions. Therefore, in this study, we try to illustrate the effect of combing on the cerebrovascular. METHODS In vivo, the anesthetized mice have been used to observe the effects of scalp mechanical stimulation. Infrared thermal imaging has been used to measure the skin temperature;vasodilation has been evaluated by retro-orbital injection of FITC-dextran 150 ku;the permeability of Blood-Brain Barrier(BBB) was analyzed by confocal microscopy of FITC-dextran 40 ku extravasation and a spectrofluorometric assay of Even Blue extravasation.RESLUTS We found that scalp mechanical stimulation rather than on the back can maintain the body temperature, especially raise the temperature in the ears. Accordingly, a moderate vasodilatation of auricles′ capillaries(≤ 8 μm) was observed, the phenomenon of which did not occur combing on the back. Furthermore, the permeability of BBB was promoted by the assays of small molecular extravasation. In addition, in vivo imaging, the small molecular of FITC-dextran(40 ku) was found to transport far away from the blood vessels into the brain parenchyma with the lapse of time. CONCLUSION Scalp mechanical stimulation can work on vasodilatation of auricles and promotion of BBB under a biological condition. Combing, as a daily behavior, simple but may yield novel insights into neuroprotection.展开更多
文摘OBJECTIVE Scalp mechanical stimulation, like combing, is one of the useful methods to keep brain health, which was historically recorded in traditional Chinese medicine thousand years ago. For the brain care, it is considered to promote cerebrovascular circulation to prevent alopecia,headache, neurasthenia, insomnia, memory deficits. However, few study was reported on its effect and how the scalp mechanical stimulation works on vascular functions. Therefore, in this study, we try to illustrate the effect of combing on the cerebrovascular. METHODS In vivo, the anesthetized mice have been used to observe the effects of scalp mechanical stimulation. Infrared thermal imaging has been used to measure the skin temperature;vasodilation has been evaluated by retro-orbital injection of FITC-dextran 150 ku;the permeability of Blood-Brain Barrier(BBB) was analyzed by confocal microscopy of FITC-dextran 40 ku extravasation and a spectrofluorometric assay of Even Blue extravasation.RESLUTS We found that scalp mechanical stimulation rather than on the back can maintain the body temperature, especially raise the temperature in the ears. Accordingly, a moderate vasodilatation of auricles′ capillaries(≤ 8 μm) was observed, the phenomenon of which did not occur combing on the back. Furthermore, the permeability of BBB was promoted by the assays of small molecular extravasation. In addition, in vivo imaging, the small molecular of FITC-dextran(40 ku) was found to transport far away from the blood vessels into the brain parenchyma with the lapse of time. CONCLUSION Scalp mechanical stimulation can work on vasodilatation of auricles and promotion of BBB under a biological condition. Combing, as a daily behavior, simple but may yield novel insights into neuroprotection.
文摘目的探讨碘克沙醇对单支及多支血管病变患者行经皮冠状动脉介入治疗(PCI)的主要不良心脑血管事件(MACCE)及对比剂诱发的急性肾功能损伤(CI-AKI)差异。方法选取自2013年10月至2015年10月中国30个中心入选的3 042例行冠状动脉支架植入术患者为研究对象。根据病变血管支数不同将患者分为单支病变(SV)组(n=2 618)与多支病变(MV)组(n=424)。主要研究终点为PCI术后72 h MACCE[包括靶病变再次血运重建(TLR)、卒中、支架内血栓、心源性死亡、非致死性心肌梗死(MI)]及CI-AKI,次要终点为PCI后72 h至30 d的MACCE发生情况。记录并比较两组患者终点事件发生率。结果SV组患者PCI手术时间、水化总体积、碘克沙醇用药时间、碘克沙醇体积低于MV组,术后水化比例、术前及术后均水化比例高于MV组,两组比较比较,差异均有统计意义(P<0.05)。两组患者病变血管、病变分级、术前心肌梗塞溶栓血流比较,差异有统计学意义(P<0.05)。两组患者主要终点事件比较:SV组MACCE、MI发生率低于MV组,两组比较,差异有统计学意义(P<0.05)。两组患者次要终点比较:SV组TLR发生率、支架内血栓发生率低于MV组,两组比较,差异有统计学意义(P<0.05)。结论应用碘克沙醇行PCI治疗后,MV患者住院期间的MACCE及MI发生率较SV患者增加,CI-AKI发生率无差异;术后72 h至30 d MV患者TLR及支架内血栓风险增加。
