目的探讨肺朗格汉斯细胞组织细胞增生症(pulmonary Langerhans cell histiocytosis,PLCH)的临床表现、影像学、病理及预后特征,以提高临床医生对该病的认识。方法回顾性分析广州医科大学附属第一医院2009年9月至2019年8月收治住院的PLC...目的探讨肺朗格汉斯细胞组织细胞增生症(pulmonary Langerhans cell histiocytosis,PLCH)的临床表现、影像学、病理及预后特征,以提高临床医生对该病的认识。方法回顾性分析广州医科大学附属第一医院2009年9月至2019年8月收治住院的PLCH患者36例,对其临床资料进行分析。根据Muller评分法进行评分,对结节状病灶、囊状病变及肺间质性病变的HRCT评分进行比较。根据患者第1次行气管镜肺活检(transbronchial lung biopsy,TBLB)是否获得阳性结果将患者分为两组:阳性组(11例)和阴性组(8例);根据确诊PLCH的肺病理中浸润组织的嗜酸粒细胞的量分为两组:较多嗜酸粒细胞浸润组(18例)和较少嗜酸粒细胞浸润组(13例);根据患者的预后分为:存活组(32例)和死亡组(4例)。对两组间的临床特征进行比较。结果36例PLCH患者发病中位年龄27.50(19.50,36.75)岁,55.56%(20/36)的患者出现过自发性气胸,36例PLCH患者的HRCT总评分平均数为(6.71±2.84)分;结节状病灶、囊状病变及肺间质性病变的HRCT评分中位数分别为2.67(0.67,4.33)分、3.67(1.75,4.33)分和0.00(0.00,1.92)分,且三者评分的差异具有统计学意义(χ^(2)=18.000,P<0.001)。囊状病变HRCT评分与第1秒用力呼气容积占预计值的百分比(the percentage of predicted value of forced expiratory volume in 1second,FEV1%pred)及第1秒用力呼气容积/用力肺活量(forced expiratory volume in 1second/forced vital capacity,FEV1/FVC)呈负相关(分别为:rs=-0.527,P=0.008;rs=-0.440,P=0.032)。19例患者进行TBLB,57.89%(11/19)第1次进行TBLB阳性组单次呼吸法肺一氧化碳弥散量占预计值的百分比(the percentage of predicted value of diffusion capacity for carbon monoxide of lung-single breath method,DLCO SB%pred)平均值为(75.19±11.91)%,明显优于阴性组[(55.43±17.10)%],差异有统计学意义(t=2.449,P=0.032);阳性组肺间质性病变HRCT评分均为0.00分,明显低于阴性组[4.50(0.00,4.92)],差异有统计学意义(Z=-2.932,P=0.020)。确诊的PLCH肺病理组织中,有较多嗜酸粒细胞浸润组有61.11%(11/18)发现结节病灶,明显多于较少嗜酸粒细胞浸润组(15.38%)(Fisher精确概率法,P=0.025)。4例(11.11%,4/36)患者死亡,死亡组(100.00%)为多系统受累的PLCH,明显多于存活组(31.25%,10/32),差异有统计学意义(Fisher精确概率法,P=0.017)。结论对于气胸为主要临床表现、囊状及结节状病变为主要影像学改变和/或伴有多系统受累的患者需考虑PLCH的可能;对于怀疑PLCH患者如弥散功能较好、HRCT中无间质性病变的表现,建议可尝试行TBLB确诊;多系统受累为预后不利因素。展开更多
Hydrothermal method was used to synthesize nanoscale particles of MnZn ferrites. The crystallites were characterized by XRD, TEM and SEM. The effects of the reaction time, temperature and additives on the product were...Hydrothermal method was used to synthesize nanoscale particles of MnZn ferrites. The crystallites were characterized by XRD, TEM and SEM. The effects of the reaction time, temperature and additives on the product were investigated. Crystallization process would be carried out above 160 ℃ for 5 h or more, higher temperature can reduce the reaction time. Additives were used to remove impurities such as Fe 2O 3, ZnMnO 3.10～15 nm pure slightly agglomerated MnZn ferrite crystallites with a narrow grain size distribution were obtained.展开更多
The hierarchical BiOX(X=Cl, Br, I) microflowers were successfully synthesized via simple precipitation method at 160 ℃ for 24 h and characterized by XRD, SEM, TEM, UV-vis DRS and N_2 adsorption-desorption techniques....The hierarchical BiOX(X=Cl, Br, I) microflowers were successfully synthesized via simple precipitation method at 160 ℃ for 24 h and characterized by XRD, SEM, TEM, UV-vis DRS and N_2 adsorption-desorption techniques. The as-prepared samples were pure phases and of microflowers composed of nanosheets which intercrossed with each other. The specific surface areas were about 22.9, 17.3 and 16.2 m^2/g for BiOCl, BiOBr and BiOI, respectively. The photocatalytic activities of BiOX powers were evaluated by RhB degradation under UV-vis light irradiation in the order of BiOCl > BiOBr > BiOI. Also, the kinetics of RhB degradation over BiOI was selectively investigated, demonstrating that the kinetics of Rh B degradation follows apparent first-order kinetics and fits the Langmuir-Hinshelwood model.展开更多
目的探讨膳食模式对开封地区糖尿病前期人群肠道菌群分布的影响。方法选取2019年9月—2020年9月于河南大学第一附属医院内分泌科就诊的糖尿病前期患者1699例,根据简化版食物摄入频率问卷调查结果分为膳食合理组和膳食不合理组,比较两组...目的探讨膳食模式对开封地区糖尿病前期人群肠道菌群分布的影响。方法选取2019年9月—2020年9月于河南大学第一附属医院内分泌科就诊的糖尿病前期患者1699例,根据简化版食物摄入频率问卷调查结果分为膳食合理组和膳食不合理组,比较两组患者的临床资料及肠道菌群水平。另采用Spearman单因素相关和多元线性回归分析膳食模式与肠道菌群的相关性。结果在本次调查中,糖尿病前期患者膳食模式合理率为41.20%(700/1699)、碳水化合物摄入合理率为53.09%(902/1699)、蛋白质摄入合理率为42.32%(719/1699)、脂肪摄入合理率为36.96%(628/1699)。膳食合理人群年龄、体质量指数(body mass index,BMI)、空腹血糖(fasting plasma glucose,FPG)及肠杆菌水平均低于膳食不合理人群,双歧杆菌和乳杆菌水平高于膳食不合理人群,差异均有统计学意义(P<0.05);Spearman相关性分析显示,FPG与肠杆菌水平呈正相关,差异有统计学意义(P<0.05);与双歧杆菌、乳杆菌水平呈负相关,差异有统计学意义(P<0.05);膳食模式与肠杆菌水平呈负相关,与双歧杆菌、乳杆菌水平呈正相关,差异均有统计学意义(P<0.05)。多元线性回归分析显示,FPG和膳食模式是糖尿病前期患者肠道菌群水平的影响因素,差异有统计学意义(P<0.05)。结论开封地区糖尿病前期患者膳食模式合理人群比例较低,不合理的膳食模式会影响肠道微生态环境的稳定性。展开更多
文摘目的探讨肺朗格汉斯细胞组织细胞增生症(pulmonary Langerhans cell histiocytosis,PLCH)的临床表现、影像学、病理及预后特征,以提高临床医生对该病的认识。方法回顾性分析广州医科大学附属第一医院2009年9月至2019年8月收治住院的PLCH患者36例,对其临床资料进行分析。根据Muller评分法进行评分,对结节状病灶、囊状病变及肺间质性病变的HRCT评分进行比较。根据患者第1次行气管镜肺活检(transbronchial lung biopsy,TBLB)是否获得阳性结果将患者分为两组:阳性组(11例)和阴性组(8例);根据确诊PLCH的肺病理中浸润组织的嗜酸粒细胞的量分为两组:较多嗜酸粒细胞浸润组(18例)和较少嗜酸粒细胞浸润组(13例);根据患者的预后分为:存活组(32例)和死亡组(4例)。对两组间的临床特征进行比较。结果36例PLCH患者发病中位年龄27.50(19.50,36.75)岁,55.56%(20/36)的患者出现过自发性气胸,36例PLCH患者的HRCT总评分平均数为(6.71±2.84)分;结节状病灶、囊状病变及肺间质性病变的HRCT评分中位数分别为2.67(0.67,4.33)分、3.67(1.75,4.33)分和0.00(0.00,1.92)分,且三者评分的差异具有统计学意义(χ^(2)=18.000,P<0.001)。囊状病变HRCT评分与第1秒用力呼气容积占预计值的百分比(the percentage of predicted value of forced expiratory volume in 1second,FEV1%pred)及第1秒用力呼气容积/用力肺活量(forced expiratory volume in 1second/forced vital capacity,FEV1/FVC)呈负相关(分别为:rs=-0.527,P=0.008;rs=-0.440,P=0.032)。19例患者进行TBLB,57.89%(11/19)第1次进行TBLB阳性组单次呼吸法肺一氧化碳弥散量占预计值的百分比(the percentage of predicted value of diffusion capacity for carbon monoxide of lung-single breath method,DLCO SB%pred)平均值为(75.19±11.91)%,明显优于阴性组[(55.43±17.10)%],差异有统计学意义(t=2.449,P=0.032);阳性组肺间质性病变HRCT评分均为0.00分,明显低于阴性组[4.50(0.00,4.92)],差异有统计学意义(Z=-2.932,P=0.020)。确诊的PLCH肺病理组织中,有较多嗜酸粒细胞浸润组有61.11%(11/18)发现结节病灶,明显多于较少嗜酸粒细胞浸润组(15.38%)(Fisher精确概率法,P=0.025)。4例(11.11%,4/36)患者死亡,死亡组(100.00%)为多系统受累的PLCH,明显多于存活组(31.25%,10/32),差异有统计学意义(Fisher精确概率法,P=0.017)。结论对于气胸为主要临床表现、囊状及结节状病变为主要影像学改变和/或伴有多系统受累的患者需考虑PLCH的可能;对于怀疑PLCH患者如弥散功能较好、HRCT中无间质性病变的表现,建议可尝试行TBLB确诊;多系统受累为预后不利因素。
文摘Hydrothermal method was used to synthesize nanoscale particles of MnZn ferrites. The crystallites were characterized by XRD, TEM and SEM. The effects of the reaction time, temperature and additives on the product were investigated. Crystallization process would be carried out above 160 ℃ for 5 h or more, higher temperature can reduce the reaction time. Additives were used to remove impurities such as Fe 2O 3, ZnMnO 3.10～15 nm pure slightly agglomerated MnZn ferrite crystallites with a narrow grain size distribution were obtained.
基金Project(21301194)supported by the National Natural Science Foundation of ChinaProject(20130162120031)supported by Research Fund for the Doctoral Program of Higher Education of China
文摘The hierarchical BiOX(X=Cl, Br, I) microflowers were successfully synthesized via simple precipitation method at 160 ℃ for 24 h and characterized by XRD, SEM, TEM, UV-vis DRS and N_2 adsorption-desorption techniques. The as-prepared samples were pure phases and of microflowers composed of nanosheets which intercrossed with each other. The specific surface areas were about 22.9, 17.3 and 16.2 m^2/g for BiOCl, BiOBr and BiOI, respectively. The photocatalytic activities of BiOX powers were evaluated by RhB degradation under UV-vis light irradiation in the order of BiOCl > BiOBr > BiOI. Also, the kinetics of RhB degradation over BiOI was selectively investigated, demonstrating that the kinetics of Rh B degradation follows apparent first-order kinetics and fits the Langmuir-Hinshelwood model.
基金Project(JCYJ20170817110251498)supported by the Basic Research Project of the Science and Technology Innovation Commission of Shenzhen,ChinaProject(2016TQ03C919)supported by the Guangdong Special Support for the Science and Technology Leading Young Scientist,ChinaProjects(21603094,21703096)supported by the National Natural Science Foundation of China
文摘目的探讨膳食模式对开封地区糖尿病前期人群肠道菌群分布的影响。方法选取2019年9月—2020年9月于河南大学第一附属医院内分泌科就诊的糖尿病前期患者1699例,根据简化版食物摄入频率问卷调查结果分为膳食合理组和膳食不合理组,比较两组患者的临床资料及肠道菌群水平。另采用Spearman单因素相关和多元线性回归分析膳食模式与肠道菌群的相关性。结果在本次调查中,糖尿病前期患者膳食模式合理率为41.20%(700/1699)、碳水化合物摄入合理率为53.09%(902/1699)、蛋白质摄入合理率为42.32%(719/1699)、脂肪摄入合理率为36.96%(628/1699)。膳食合理人群年龄、体质量指数(body mass index,BMI)、空腹血糖(fasting plasma glucose,FPG)及肠杆菌水平均低于膳食不合理人群,双歧杆菌和乳杆菌水平高于膳食不合理人群,差异均有统计学意义(P<0.05);Spearman相关性分析显示,FPG与肠杆菌水平呈正相关,差异有统计学意义(P<0.05);与双歧杆菌、乳杆菌水平呈负相关,差异有统计学意义(P<0.05);膳食模式与肠杆菌水平呈负相关,与双歧杆菌、乳杆菌水平呈正相关,差异均有统计学意义(P<0.05)。多元线性回归分析显示,FPG和膳食模式是糖尿病前期患者肠道菌群水平的影响因素,差异有统计学意义(P<0.05)。结论开封地区糖尿病前期患者膳食模式合理人群比例较低,不合理的膳食模式会影响肠道微生态环境的稳定性。
