Two positive d 13C excursions are presented in records from the Frasnian-Famennian (F-F) marine carbon-ate sediments in Europe, America, Africa, and Australia, having been considered as a worldwide pattern, and attrib...Two positive d 13C excursions are presented in records from the Frasnian-Famennian (F-F) marine carbon-ate sediments in Europe, America, Africa, and Australia, having been considered as a worldwide pattern, and attrib-uted to enhanced organic carbon burial during the F-F biological mass extinction. However, this worldwide pattern has not been revealed from the well-deposited Late Devonian sequences in southern China. In this paper, a detailed inves-tigation has been made on the Late Devonian section at Dongcun, Guilin, southern China to constrain perturbations in d 13C of carbonates in the F-F deposited sequence. The result from this section also indicates two positive d 13C ex-cursions during the F-F transition. The first excursion with an amplitude of 1.5 occurred at the bottom of linguiformis Zone, later than the early excursion existing in the Late rhe-nana Zone of the Late Devonian profiles in other continents, especially, in central Europe. This difference has been ex-pected to be a result as conodont Palmatolepis linguiformis occurred earlier in southern China than other sites. The second excursion with an amplitude of 2.1 is located at the F-F boundary, same as the records from other continents. This result strongly supports the view that two carbon iso-tope positive excursions during the F-F transition are com-mon in carbonate sediments, resulting from worldwide in-creases of organic carbon burial intensity.展开更多
目的探讨成年人群血清C肽与胰岛素的相关性,建立血清C肽对应的胰岛素值。方法横断面研究。回顾性纳入2017年1月至2021年12月于解放军总医院第二医学中心行健康体检的成年人群的临床资料,根据糖尿病诊断标准将受试者分为2型糖尿病组、糖...目的探讨成年人群血清C肽与胰岛素的相关性,建立血清C肽对应的胰岛素值。方法横断面研究。回顾性纳入2017年1月至2021年12月于解放军总医院第二医学中心行健康体检的成年人群的临床资料,根据糖尿病诊断标准将受试者分为2型糖尿病组、糖尿病前期组和正常血糖组。采用Pearson相关分析、线性回归分析和非线性回归分析等方法探讨血清C肽与胰岛素的相关性,并建立血清C肽对应的胰岛素值。结果共纳入48008名成年受试者,男31633名(65.9%),女16375名(34.1%),年龄(50.1±9.9)岁(18~89岁);其中2型糖尿病组8160例(17.0%),糖尿病前期组13263例(27.6%),正常血糖组26585名(55.4%)。3组血清空腹C肽[FCP,M(Q_(1),Q_(3))]分别为2.76(2.18,3.47)、2.54(1.99,3.21)和2.18(1.71,2.79)μg/L;3组空腹胰岛素[FINS,M(Q_(1),Q_(3))]分别为10.98(7.57,16.09)、10.06(6.95,14.47)和8.43(5.86,12.12)mU/L。FCP与FINS(r=0.82)、餐后2 h C肽(2 h CP)与餐后2 h胰岛素(2 h INS)(r=0.84)均呈正相关(P<0.001)。FCP与FINS(R^(2)=0.68)、2 h CP与2 h INS(R^(2)=0.71)均呈线性相关(P<0.001)。FCP与FINS(R^(2)=0.74)、2 h CP与2 h INS(R^(2)=0.78)均呈幂函数相关(P<0.001),不同糖代谢状态亚组分析结果相似。幂函数模型拟合度高于线性模型,幂函数模型为最佳模型,幂函数方程分别为FINS=2.96×FCP^(1.32)、2 h INS=1.64×(2 h CP)^(1.60)。多因素线性回归分析显示,在调整相关混杂因素后,FCP是FINS(R^(2)=0.70,P<0.001)的相关因素,2 h CP是2 h INS(R^(2)=0.73,P<0.001)的相关因素。结论成年人群FCP与FINS、2 h CP与2 h INS均呈幂函数相关。本研究建立血清C肽水平分别对应的胰岛素值。展开更多
目的观察社区护理对绝经后骨质疏松女性的干预效果。方法选取三亚市2017年6月1日-2019年1月1日某区农村187例60岁以上无重大疾病的绝经期女性,根据随机数字表进行分组,分为干预组(n=93)和对照组(n=92),均对其24小时尿钙值进行检测,其中...目的观察社区护理对绝经后骨质疏松女性的干预效果。方法选取三亚市2017年6月1日-2019年1月1日某区农村187例60岁以上无重大疾病的绝经期女性,根据随机数字表进行分组,分为干预组(n=93)和对照组(n=92),均对其24小时尿钙值进行检测,其中干预组需定期进行社区(心理、运动、饮食)护理,干预1年时间。对比两组前后1年时间24小时尿钙值的变化,及对24小时尿钙值与骨质疏松之间的关系进行横断面相关性分析,进而评价干预效果。结果通过护理1年后对两组的尿钙值及骨密度比较发现,24小时尿钙值确实有不同程度的下降,干预组与对照组尿钙值情况比较(2.39±0.39 VS 3.55±0.41)及骨质异常情况比较均有统计学意义。通过尿钙与骨量的拟合曲线的结果发现,24小时尿钙值在3.62mmol/天以上的绝经期女性骨量减少的风险明显上升。结论对农村绝经期女性骨质疏松进行积极社区护理干预措施可以有效降低24小时尿钙值,并可能预防或延缓骨质疏松的发生发展。24小时尿钙检测作为评价骨质疏松护理干预效果的一个辅助指标,可以推广。展开更多
Reconstructing the evolutionary history of the Gobi deserts developed from alluvial sediments in arid regions has great significance in unraveling changes in both tectonic activity and climate.However,such work is lim...Reconstructing the evolutionary history of the Gobi deserts developed from alluvial sediments in arid regions has great significance in unraveling changes in both tectonic activity and climate.However,such work is limited by a lack of suitable dating material preserved in the Gobi Desert,but cosmogenic 10Be has great potential to date the Gobi deserts.In the present study,10Be in quartz gravel from the Gobi deserts of the Ejina Basin in Inner Mongolia of China has been measured to assess exposure ages.Results show that the Gobi Desert in the northern margin of the basin developed 420 ka ago,whereas the Gobi Desert that developed from alluvial plains in the Heihe River drainage basin came about during the last 190 ka.The latter developed gradually northward and eastward to modern terminal lakes of the river.These temporal and spatial variations in the Gobi deserts are a consequence of alluvial processes influenced by Tibetan Plateau uplift and tectonic activities within the Ejina Basin.Possible episodes of Gobi Desert development within the last 420 ka indicate that the advance/retreat of alpine glaciers during glacial/interglacial cycles might have been the dominant factor to influencing the alluvial intensity and water volume in the basin.Intense floods and large water volumes would mainly occur during the short deglacial periods.展开更多
Knowledge of seasonal climate change is one of the key issues facing Quaternary paleoclimatic studies and estimating seasonal climate change is difficult,especially changes such as seasonal length on glacial-interglac...Knowledge of seasonal climate change is one of the key issues facing Quaternary paleoclimatic studies and estimating seasonal climate change is difficult,especially changes such as seasonal length on glacial-interglacial timescales.The stable isotope composition from seasonal land snail shells provides the potential to reveal seasonal climatic features.Two modern land snail species,cold-aridiphilous Pupilla aeoli and thermo-humidiphilous Punctum orphana,were collected from different climatic zones in 18 localities across the Chinese Loess Plateau,spanning 11 degrees of longitude and covering a range of 1000 km2.The duration of the snail growing season(temperature ≥10℃) was shorter(202 ± 6 d) in the eastern Loess Plateau compared with in the western Loess Plateau(162 ±7 d).The δ13C of P.aeoli shells was ?9.1‰ to ?4.7‰ and ?5.0‰ to 0.3‰ for δ18O.For P.orphana,the δ13C ranged from ?9.1‰ to ?1.9‰ and ?8.9‰ to ?2.9‰ for δ18O.Both the δ13C and δ18O differences between the two snail species were reduced from the east to the western Loess Plateau(2.8‰ to 0.2 ± 1.1‰ for δ13C and 4.7‰ to 2.9 ± 1.3‰ for δ18O).These isotopic differences roughly reflect the difference in the growing season lengths between the east and west Loess Plateau indicating that the duration of the snail growing season shortens by 15 d or 19 d if the difference decreases by 1‰ in δ13C or δ18O,respectively.Thus,the difference in δ13C and δ18O between both snail species can be used to reveal the length of the snail growing season in the past.Based on our investigation,the length of the snail growing seasons from the Xifeng region during the last 75 ka was reconstructed.During the mid-Holocene(8-3 ka),the mean isotopic difference from both snail species reached maximum values of 2.6 ± 0.7‰ and 2.1 ± 1.4‰ for δ13C and δ18O,respectively.This was followed by MIS 3 that ranged from 2.5 ± 0.4‰ for δ13C and 1.6 ± 0.8‰ for δ18O.The Last Glacial Maximum changed by only 0.2‰ and 0.4‰ for δ13C and δ18O,respectively.Therefore,we estimate that the duration of the snail growing seasons to be ～200 ± 10 d during the mid-Holocene,190 ± 6 d in MIS 3 and 160 ± 3 d during the last glacial period.展开更多
文摘Two positive d 13C excursions are presented in records from the Frasnian-Famennian (F-F) marine carbon-ate sediments in Europe, America, Africa, and Australia, having been considered as a worldwide pattern, and attrib-uted to enhanced organic carbon burial during the F-F biological mass extinction. However, this worldwide pattern has not been revealed from the well-deposited Late Devonian sequences in southern China. In this paper, a detailed inves-tigation has been made on the Late Devonian section at Dongcun, Guilin, southern China to constrain perturbations in d 13C of carbonates in the F-F deposited sequence. The result from this section also indicates two positive d 13C ex-cursions during the F-F transition. The first excursion with an amplitude of 1.5 occurred at the bottom of linguiformis Zone, later than the early excursion existing in the Late rhe-nana Zone of the Late Devonian profiles in other continents, especially, in central Europe. This difference has been ex-pected to be a result as conodont Palmatolepis linguiformis occurred earlier in southern China than other sites. The second excursion with an amplitude of 2.1 is located at the F-F boundary, same as the records from other continents. This result strongly supports the view that two carbon iso-tope positive excursions during the F-F transition are com-mon in carbonate sediments, resulting from worldwide in-creases of organic carbon burial intensity.
文摘目的探讨成年人群血清C肽与胰岛素的相关性,建立血清C肽对应的胰岛素值。方法横断面研究。回顾性纳入2017年1月至2021年12月于解放军总医院第二医学中心行健康体检的成年人群的临床资料,根据糖尿病诊断标准将受试者分为2型糖尿病组、糖尿病前期组和正常血糖组。采用Pearson相关分析、线性回归分析和非线性回归分析等方法探讨血清C肽与胰岛素的相关性,并建立血清C肽对应的胰岛素值。结果共纳入48008名成年受试者,男31633名(65.9%),女16375名(34.1%),年龄(50.1±9.9)岁(18~89岁);其中2型糖尿病组8160例(17.0%),糖尿病前期组13263例(27.6%),正常血糖组26585名(55.4%)。3组血清空腹C肽[FCP,M(Q_(1),Q_(3))]分别为2.76(2.18,3.47)、2.54(1.99,3.21)和2.18(1.71,2.79)μg/L;3组空腹胰岛素[FINS,M(Q_(1),Q_(3))]分别为10.98(7.57,16.09)、10.06(6.95,14.47)和8.43(5.86,12.12)mU/L。FCP与FINS(r=0.82)、餐后2 h C肽(2 h CP)与餐后2 h胰岛素(2 h INS)(r=0.84)均呈正相关(P<0.001)。FCP与FINS(R^(2)=0.68)、2 h CP与2 h INS(R^(2)=0.71)均呈线性相关(P<0.001)。FCP与FINS(R^(2)=0.74)、2 h CP与2 h INS(R^(2)=0.78)均呈幂函数相关(P<0.001),不同糖代谢状态亚组分析结果相似。幂函数模型拟合度高于线性模型,幂函数模型为最佳模型,幂函数方程分别为FINS=2.96×FCP^(1.32)、2 h INS=1.64×(2 h CP)^(1.60)。多因素线性回归分析显示,在调整相关混杂因素后,FCP是FINS(R^(2)=0.70,P<0.001)的相关因素,2 h CP是2 h INS(R^(2)=0.73,P<0.001)的相关因素。结论成年人群FCP与FINS、2 h CP与2 h INS均呈幂函数相关。本研究建立血清C肽水平分别对应的胰岛素值。
文摘目的观察社区护理对绝经后骨质疏松女性的干预效果。方法选取三亚市2017年6月1日-2019年1月1日某区农村187例60岁以上无重大疾病的绝经期女性,根据随机数字表进行分组,分为干预组(n=93)和对照组(n=92),均对其24小时尿钙值进行检测,其中干预组需定期进行社区(心理、运动、饮食)护理,干预1年时间。对比两组前后1年时间24小时尿钙值的变化,及对24小时尿钙值与骨质疏松之间的关系进行横断面相关性分析,进而评价干预效果。结果通过护理1年后对两组的尿钙值及骨密度比较发现,24小时尿钙值确实有不同程度的下降,干预组与对照组尿钙值情况比较(2.39±0.39 VS 3.55±0.41)及骨质异常情况比较均有统计学意义。通过尿钙与骨量的拟合曲线的结果发现,24小时尿钙值在3.62mmol/天以上的绝经期女性骨量减少的风险明显上升。结论对农村绝经期女性骨质疏松进行积极社区护理干预措施可以有效降低24小时尿钙值,并可能预防或延缓骨质疏松的发生发展。24小时尿钙检测作为评价骨质疏松护理干预效果的一个辅助指标,可以推广。
基金supported by the Knowledge Innovation Program of the Chinese Academy of Sciences(KZCX2-YW-117)the National Natural Science Foundation of China(40841022 and 40373046)
文摘Reconstructing the evolutionary history of the Gobi deserts developed from alluvial sediments in arid regions has great significance in unraveling changes in both tectonic activity and climate.However,such work is limited by a lack of suitable dating material preserved in the Gobi Desert,but cosmogenic 10Be has great potential to date the Gobi deserts.In the present study,10Be in quartz gravel from the Gobi deserts of the Ejina Basin in Inner Mongolia of China has been measured to assess exposure ages.Results show that the Gobi Desert in the northern margin of the basin developed 420 ka ago,whereas the Gobi Desert that developed from alluvial plains in the Heihe River drainage basin came about during the last 190 ka.The latter developed gradually northward and eastward to modern terminal lakes of the river.These temporal and spatial variations in the Gobi deserts are a consequence of alluvial processes influenced by Tibetan Plateau uplift and tectonic activities within the Ejina Basin.Possible episodes of Gobi Desert development within the last 420 ka indicate that the advance/retreat of alpine glaciers during glacial/interglacial cycles might have been the dominant factor to influencing the alluvial intensity and water volume in the basin.Intense floods and large water volumes would mainly occur during the short deglacial periods.
基金supported by the National Basic Research Program of China (2010CB950204)Strategic Priority Research Program of the Chinese Academy of Sciences (XDA05120203)the National Natural Science Foundation of China (40972119 and 40730104)
文摘Knowledge of seasonal climate change is one of the key issues facing Quaternary paleoclimatic studies and estimating seasonal climate change is difficult,especially changes such as seasonal length on glacial-interglacial timescales.The stable isotope composition from seasonal land snail shells provides the potential to reveal seasonal climatic features.Two modern land snail species,cold-aridiphilous Pupilla aeoli and thermo-humidiphilous Punctum orphana,were collected from different climatic zones in 18 localities across the Chinese Loess Plateau,spanning 11 degrees of longitude and covering a range of 1000 km2.The duration of the snail growing season(temperature ≥10℃) was shorter(202 ± 6 d) in the eastern Loess Plateau compared with in the western Loess Plateau(162 ±7 d).The δ13C of P.aeoli shells was ?9.1‰ to ?4.7‰ and ?5.0‰ to 0.3‰ for δ18O.For P.orphana,the δ13C ranged from ?9.1‰ to ?1.9‰ and ?8.9‰ to ?2.9‰ for δ18O.Both the δ13C and δ18O differences between the two snail species were reduced from the east to the western Loess Plateau(2.8‰ to 0.2 ± 1.1‰ for δ13C and 4.7‰ to 2.9 ± 1.3‰ for δ18O).These isotopic differences roughly reflect the difference in the growing season lengths between the east and west Loess Plateau indicating that the duration of the snail growing season shortens by 15 d or 19 d if the difference decreases by 1‰ in δ13C or δ18O,respectively.Thus,the difference in δ13C and δ18O between both snail species can be used to reveal the length of the snail growing season in the past.Based on our investigation,the length of the snail growing seasons from the Xifeng region during the last 75 ka was reconstructed.During the mid-Holocene(8-3 ka),the mean isotopic difference from both snail species reached maximum values of 2.6 ± 0.7‰ and 2.1 ± 1.4‰ for δ13C and δ18O,respectively.This was followed by MIS 3 that ranged from 2.5 ± 0.4‰ for δ13C and 1.6 ± 0.8‰ for δ18O.The Last Glacial Maximum changed by only 0.2‰ and 0.4‰ for δ13C and δ18O,respectively.Therefore,we estimate that the duration of the snail growing seasons to be ～200 ± 10 d during the mid-Holocene,190 ± 6 d in MIS 3 and 160 ± 3 d during the last glacial period.
