目的采用系统评价探索高度近视的发展与炎症因子表达的相关性。方法检索PubMed、Cochrane Library、Web of Science、中国知网、万方、维普6个数据库的相关文献,收集自建库至2022年10月31日所有有关近视与炎症相关性的病例对照研究、队...目的采用系统评价探索高度近视的发展与炎症因子表达的相关性。方法检索PubMed、Cochrane Library、Web of Science、中国知网、万方、维普6个数据库的相关文献,收集自建库至2022年10月31日所有有关近视与炎症相关性的病例对照研究、队列研究和横断面研究,采用纽卡斯尔-渥太华量表(NOS)进行质量评价,RevMan 5.3软件进行Meta分析。结果共纳入6项研究,498例患者,NOS量表评分7~8分,均为高质量文献;近视相关炎症因子包括白细胞介素-8(IL-8)、白细胞介素-10(IL-10)、白细胞介素-1受体拮抗剂(IL-1ra)、白细胞介素-6(IL-6)。高度近视组患者房水中的IL-8[SMD=-0.410,95%CI(-0.670,-0.150),Z=3.070,P=0.002]、IL-10[SMD=-0.460,95%CI(-0.770,-0.150),Z=2.950,P=0.003]、IL-1ra[SMD=-0.590,95%CI(-0.870,-0.310),Z=4.170,P=0.000]水平均高于低度近视或正常组,而IL-6水平差异无统计学意义(P>0.05)。结论高度近视患者眼内IL-8、IL-10、IL-1ra等炎症因子水平高于正常或低度近视患者,其可能导致了近视相关的一系列并发症并诱导近视的发展,但以上结论还需进一步高质量观察性研究数据证实。展开更多
A connected graph G=(V(G),E(G)) is called a quasi-unicyclic graph,if there exists u0∈V(G) such that G-u0 is a unicyclic graph.Denote Q(n,d0)={G:G is a quasi-unicyclic graph of order n with G-u0 being a unicyclic grap...A connected graph G=(V(G),E(G)) is called a quasi-unicyclic graph,if there exists u0∈V(G) such that G-u0 is a unicyclic graph.Denote Q(n,d0)={G:G is a quasi-unicyclic graph of order n with G-u0 being a unicyclic graph and dG(u0)=d0}.Let A(G) be the adjacency matrix of a graph G,and let λ1(G),λ2(G),…,λn(G) be the eigenvalues in non-increasing order of A(G).The number n∑i=1λi^k(k=0,1,…,n-1) is called the k-th spectral moment of G,denoted by Sk(G).Let S(G)=(S0(G),S1(G),…,Sn-1(G)) be the sequence of spectral moments of G.For two graphs G1,G2,we have■ if for some k(k=1,2,…,n-1), and we have Si(G1)=Si(G2)(i=0,1,…,k-1) and Sk(G1)<Sk(G2).In this paper,we determine the second to the fourth largest quasi-unicyclic graphs,in an S-order,in the set Q(n,d0),respectively.展开更多
文摘目的采用系统评价探索高度近视的发展与炎症因子表达的相关性。方法检索PubMed、Cochrane Library、Web of Science、中国知网、万方、维普6个数据库的相关文献,收集自建库至2022年10月31日所有有关近视与炎症相关性的病例对照研究、队列研究和横断面研究,采用纽卡斯尔-渥太华量表(NOS)进行质量评价,RevMan 5.3软件进行Meta分析。结果共纳入6项研究,498例患者,NOS量表评分7~8分,均为高质量文献;近视相关炎症因子包括白细胞介素-8(IL-8)、白细胞介素-10(IL-10)、白细胞介素-1受体拮抗剂(IL-1ra)、白细胞介素-6(IL-6)。高度近视组患者房水中的IL-8[SMD=-0.410,95%CI(-0.670,-0.150),Z=3.070,P=0.002]、IL-10[SMD=-0.460,95%CI(-0.770,-0.150),Z=2.950,P=0.003]、IL-1ra[SMD=-0.590,95%CI(-0.870,-0.310),Z=4.170,P=0.000]水平均高于低度近视或正常组,而IL-6水平差异无统计学意义(P>0.05)。结论高度近视患者眼内IL-8、IL-10、IL-1ra等炎症因子水平高于正常或低度近视患者,其可能导致了近视相关的一系列并发症并诱导近视的发展,但以上结论还需进一步高质量观察性研究数据证实。
基金Supported by China Scholarship Council(201808420093)Research Project of Education Bureau of Wuhan(2014017)
文摘A connected graph G=(V(G),E(G)) is called a quasi-unicyclic graph,if there exists u0∈V(G) such that G-u0 is a unicyclic graph.Denote Q(n,d0)={G:G is a quasi-unicyclic graph of order n with G-u0 being a unicyclic graph and dG(u0)=d0}.Let A(G) be the adjacency matrix of a graph G,and let λ1(G),λ2(G),…,λn(G) be the eigenvalues in non-increasing order of A(G).The number n∑i=1λi^k(k=0,1,…,n-1) is called the k-th spectral moment of G,denoted by Sk(G).Let S(G)=(S0(G),S1(G),…,Sn-1(G)) be the sequence of spectral moments of G.For two graphs G1,G2,we have■ if for some k(k=1,2,…,n-1), and we have Si(G1)=Si(G2)(i=0,1,…,k-1) and Sk(G1)<Sk(G2).In this paper,we determine the second to the fourth largest quasi-unicyclic graphs,in an S-order,in the set Q(n,d0),respectively.
