Objective:To explore whether maternal stress exposure during pregnancy impairs cognitive function and white matter ultrastructure in offspring mice.Methods:The parent rats were divided into two groups:pressure exposur...Objective:To explore whether maternal stress exposure during pregnancy impairs cognitive function and white matter ultrastructure in offspring mice.Methods:The parent rats were divided into two groups:pressure exposure group(group PE)and control group(group C),and the positive date of vaginal smear of female SD rats was day 0 of gestation.Female mice in group PE were exposed to binding pressure(3 times/day)on day 14-20 of gestation for 45 min-1 h/time.Behavioral tests(Morris water maze and Y maze)were performed on 1-month-old offspring mice followed by cardiac perfusion of fixed brain specimens and placement in mixed fixative solution.The total volume of white matter,total length and volume of myelinated nerve fibers and total length and volume of myelin sheath were calculated using modern stereoscopic methods,and the inner and outer diameter and inner and outer circumference of the myelin sheath were analyzed.Results:1)Behavioral tests:compared with the group C,the average latency of the 3th and 4th day in the group PE were significantly prolonged,the percentage of the resting time in the quadrant of the platform and the frequency of acrossing the effective area of platform in the fifth day of space exploration experiment were significantly reduced of Morris water maze test,and visiting distance,duration and numbers in novel arm significantly increased of Y-maze test(P<0.05).2)Compared with group C,the total volume of white matter,total length of myelinated nerve fibers,total volume of myelinated nerve fibers and myelin sheath in the group PE were significantly reduced(P<0.05),the inner diameter and outer diameter of myelin sheath decreased significantly(P<0.05),and the inner perimeter,outer perimeter and inner and outer perimeter differences increased significantly(P<0.05).3)There was a correlation between behavioral test results and white matter ultrastructure measurement results.Conclusions:Maternal stress exposure during pregnancy could impair the cognitive function and white matter and its ultrastructure in the offspring,and there was a correlation between decreased cognitive function and white matter damages.展开更多
针对核相关滤波器在跟踪中因目标快速运动导致的目标易丢失和部分遮挡问题,本文在多特征尺度自适应核相关滤波器(Scale Adaptive with Multiple Features tracker,SAMF)基础上,提出一种融合自适应模板更新和预测目标位置重定位的核相关...针对核相关滤波器在跟踪中因目标快速运动导致的目标易丢失和部分遮挡问题,本文在多特征尺度自适应核相关滤波器(Scale Adaptive with Multiple Features tracker,SAMF)基础上,提出一种融合自适应模板更新和预测目标位置重定位的核相关跟踪算法。采用联合目标移动速度和特征变化的模板更新机制增大对目标快速运动适应性,根据长时滤波器和短时滤波器协作跟踪提出目标位置修正和重定位模型提升跟踪器应对目标部分遮挡的能力。在OTB-2015视频序列集100组序列中与序列集提供的算法进行对比,本算法跟踪精度相比SAMF提升2%。在目标发生快速移动时本文算法具有更好的追踪目标能力,目标重定位也很好地解决了目标部分遮挡问题。展开更多
基金Shaanxi Province natural science basic research program (No.2023-JC-QN-0961)。
文摘Objective:To explore whether maternal stress exposure during pregnancy impairs cognitive function and white matter ultrastructure in offspring mice.Methods:The parent rats were divided into two groups:pressure exposure group(group PE)and control group(group C),and the positive date of vaginal smear of female SD rats was day 0 of gestation.Female mice in group PE were exposed to binding pressure(3 times/day)on day 14-20 of gestation for 45 min-1 h/time.Behavioral tests(Morris water maze and Y maze)were performed on 1-month-old offspring mice followed by cardiac perfusion of fixed brain specimens and placement in mixed fixative solution.The total volume of white matter,total length and volume of myelinated nerve fibers and total length and volume of myelin sheath were calculated using modern stereoscopic methods,and the inner and outer diameter and inner and outer circumference of the myelin sheath were analyzed.Results:1)Behavioral tests:compared with the group C,the average latency of the 3th and 4th day in the group PE were significantly prolonged,the percentage of the resting time in the quadrant of the platform and the frequency of acrossing the effective area of platform in the fifth day of space exploration experiment were significantly reduced of Morris water maze test,and visiting distance,duration and numbers in novel arm significantly increased of Y-maze test(P<0.05).2)Compared with group C,the total volume of white matter,total length of myelinated nerve fibers,total volume of myelinated nerve fibers and myelin sheath in the group PE were significantly reduced(P<0.05),the inner diameter and outer diameter of myelin sheath decreased significantly(P<0.05),and the inner perimeter,outer perimeter and inner and outer perimeter differences increased significantly(P<0.05).3)There was a correlation between behavioral test results and white matter ultrastructure measurement results.Conclusions:Maternal stress exposure during pregnancy could impair the cognitive function and white matter and its ultrastructure in the offspring,and there was a correlation between decreased cognitive function and white matter damages.
文摘针对核相关滤波器在跟踪中因目标快速运动导致的目标易丢失和部分遮挡问题,本文在多特征尺度自适应核相关滤波器(Scale Adaptive with Multiple Features tracker,SAMF)基础上,提出一种融合自适应模板更新和预测目标位置重定位的核相关跟踪算法。采用联合目标移动速度和特征变化的模板更新机制增大对目标快速运动适应性,根据长时滤波器和短时滤波器协作跟踪提出目标位置修正和重定位模型提升跟踪器应对目标部分遮挡的能力。在OTB-2015视频序列集100组序列中与序列集提供的算法进行对比,本算法跟踪精度相比SAMF提升2%。在目标发生快速移动时本文算法具有更好的追踪目标能力,目标重定位也很好地解决了目标部分遮挡问题。
