为了探讨淋巴细胞白血病缺失基因1 (deleted in lymphocytic leukemia 1, DLEU1)的功能及其在膀胱癌发展进程中相关联的基因及信号通路,采用Atlas of Genetics and Cytogenetics in Oncology and Haematology、Dcode、NCBI、GWAS Catalo...为了探讨淋巴细胞白血病缺失基因1 (deleted in lymphocytic leukemia 1, DLEU1)的功能及其在膀胱癌发展进程中相关联的基因及信号通路,采用Atlas of Genetics and Cytogenetics in Oncology and Haematology、Dcode、NCBI、GWAS Catalog、Targetvalidation、FireBrowse、Wanderer、GEPIA、Multi Experiment Matrix和LinkedOmics等综合分析DLEU1基因的功能。结果显示:DLEU1基因定位于人13q14.2～q14.3且高度保守;该基因广泛表达于人体多种正常组织,并与身高、原发性胆汁性肝硬化等生物学表型相关;在膀胱癌等多种肿瘤中广泛高表达,且其高表达与膀胱癌总体生存率和无病生存率的显著降低相关。此外,基因信号通路富集分析结果显示,在膀胱癌等多种肿瘤中DLEU1均与ncRNA代谢途径密切相关。以上结果提示, DLEU1可能是膀胱癌潜在的癌基因和治疗靶点,其主要通过调节ncRNA代谢途径参与膀胱癌的进程。展开更多
A novel whispering gallery mode(WGM) strain sensor based on microtube has been proposed, where perceiving strain variations are reported via the dynamical regulation of a whispering gallery mode. The WGMs in the micro...A novel whispering gallery mode(WGM) strain sensor based on microtube has been proposed, where perceiving strain variations are reported via the dynamical regulation of a whispering gallery mode. The WGMs in the microtube resonator were evanescently excited by a micro-nano fiber fabricated by the fusion taper technique. The structural changes of microtubes under axial strain were simulated with finite element software, and the effect of microtube wall thickness on strain sensitivity was systematically studied through experiments. The experimental results show that the strain sensitivity of thin-walled microtube is found to be 1.18 pm/με and the Q-factor in the order of 4.4× 104. Due to its simple fabrication and easy manipulation as well as good sensing performance, the microtube strain sensor has potential applications in high-sensitivity optical sensing.展开更多
Theoretical design of a neotype fluidic controlling sensor system based on side-polished optical fiber is proposed.Numerical investigations demonstrate that the higher birefringence and resonance coupling can be achie...Theoretical design of a neotype fluidic controlling sensor system based on side-polished optical fiber is proposed.Numerical investigations demonstrate that the higher birefringence and resonance coupling can be achieved by flexible design of the polishing shape and depth in the research wavelength.The fluidic system is beneficial to selective integration of functional materials.The material is integrated into the fluidic system,which can achieve a birefringence up to 6.98×10^-5,and the application of Sagnac thermometer in temperature sensing is studied,and a group of dips with different temperature sensitivities would be observed in the transmission spectra,which is about 1.6 nm/℃by calculating.furthermore,by introducing resonant coupling,single mode single polarization at 1310 nm is realized.The refractive index(RI)response of the sensing system for a low Grange of 1.39-1.37 is approximately linear,and exhibits a sensitivity of 6338 nm/RlU.The results show that the proposed neotype fluidic controlling system can be used as a flexible polarization filter or as a potential two-parameter sensor.展开更多
A temperature-insensitive polarization filter and a neotype sensor based on a hybrid-circular-hole microstructured optical fiber(MOF) are proposed. Numerical investigations demonstrate that the x polarized component o...A temperature-insensitive polarization filter and a neotype sensor based on a hybrid-circular-hole microstructured optical fiber(MOF) are proposed. Numerical investigations demonstrate that the x polarized component of silica core mode can couple to the cladding mode in the researched wavelength, while the y polarized component would not. Furthermore, the resonant region can be controlled by changing the diameters or coordinates of the air holes, and the MOF has good performance on stability of temperature. Moreover, the hybrid-circular-hole structure is propitious to selectively integrate different functional materials. Two different materials are integrated into this proposed MOF, the application of the Sagnac interferometer in temperature sensing is studied, and two groups of dips would be observed in the transmission spectra, which have different temperature sensitivities. Therefore, the proposed MOF can be used as a flexible temperature-insensitive polarization filter or potentially applied to a two-parameter sensor.展开更多
文摘为了探讨淋巴细胞白血病缺失基因1 (deleted in lymphocytic leukemia 1, DLEU1)的功能及其在膀胱癌发展进程中相关联的基因及信号通路,采用Atlas of Genetics and Cytogenetics in Oncology and Haematology、Dcode、NCBI、GWAS Catalog、Targetvalidation、FireBrowse、Wanderer、GEPIA、Multi Experiment Matrix和LinkedOmics等综合分析DLEU1基因的功能。结果显示:DLEU1基因定位于人13q14.2～q14.3且高度保守;该基因广泛表达于人体多种正常组织,并与身高、原发性胆汁性肝硬化等生物学表型相关;在膀胱癌等多种肿瘤中广泛高表达,且其高表达与膀胱癌总体生存率和无病生存率的显著降低相关。此外,基因信号通路富集分析结果显示,在膀胱癌等多种肿瘤中DLEU1均与ncRNA代谢途径密切相关。以上结果提示, DLEU1可能是膀胱癌潜在的癌基因和治疗靶点,其主要通过调节ncRNA代谢途径参与膀胱癌的进程。
基金supported by the National Key R&D Program of China(Nos.2018YFF01010202 and 2018YFF01010201)the National Natural Science Foundation of China(Nos.61705027 and 11704053)the Basic Research Project of Chongqing Science and Technology Commission(Nos.CSTC-2017csms A40017 and CSTC-2018jcyjax0619)。
文摘A novel whispering gallery mode(WGM) strain sensor based on microtube has been proposed, where perceiving strain variations are reported via the dynamical regulation of a whispering gallery mode. The WGMs in the microtube resonator were evanescently excited by a micro-nano fiber fabricated by the fusion taper technique. The structural changes of microtubes under axial strain were simulated with finite element software, and the effect of microtube wall thickness on strain sensitivity was systematically studied through experiments. The experimental results show that the strain sensitivity of thin-walled microtube is found to be 1.18 pm/με and the Q-factor in the order of 4.4× 104. Due to its simple fabrication and easy manipulation as well as good sensing performance, the microtube strain sensor has potential applications in high-sensitivity optical sensing.
基金supported by the National Key R&D Program of China(Nos.2018YFF01010202 and 2018YFF01010201)the National Natural Science Foundation of China(Nos.61705027 and 11704053)+3 种基金the Government of the Russian Federation(No.08-08)the Innovation Leader Talent Project of Chongqing Science and Technology(No.CSTC-CXLJRC201711)the Basic Research Project of Chongqing Science and Technology Commission(Nos.CSTC-2017csms A40017 and CSTC-2018jcyjax0619)the Science and Technology Project Affiliated to the Education Department of Chongqing Municipality(Nos.KJZH17115 and KJQN201800626)。
文摘Theoretical design of a neotype fluidic controlling sensor system based on side-polished optical fiber is proposed.Numerical investigations demonstrate that the higher birefringence and resonance coupling can be achieved by flexible design of the polishing shape and depth in the research wavelength.The fluidic system is beneficial to selective integration of functional materials.The material is integrated into the fluidic system,which can achieve a birefringence up to 6.98×10^-5,and the application of Sagnac thermometer in temperature sensing is studied,and a group of dips with different temperature sensitivities would be observed in the transmission spectra,which is about 1.6 nm/℃by calculating.furthermore,by introducing resonant coupling,single mode single polarization at 1310 nm is realized.The refractive index(RI)response of the sensing system for a low Grange of 1.39-1.37 is approximately linear,and exhibits a sensitivity of 6338 nm/RlU.The results show that the proposed neotype fluidic controlling system can be used as a flexible polarization filter or as a potential two-parameter sensor.
基金supported by the National Natural Science Foundation of China(Nos.61705027 and 11704053)the Innovation Leader Talent Project of Chongqing Science and Technology(No.CSTCCXLJR20171160)the Basic Research Project of Chongqing Science and Technology Commission(Nos.KJZH17115,Cstc2017csms A40017,KJ1704091,KJ1704104 and KJ1704106)
文摘A temperature-insensitive polarization filter and a neotype sensor based on a hybrid-circular-hole microstructured optical fiber(MOF) are proposed. Numerical investigations demonstrate that the x polarized component of silica core mode can couple to the cladding mode in the researched wavelength, while the y polarized component would not. Furthermore, the resonant region can be controlled by changing the diameters or coordinates of the air holes, and the MOF has good performance on stability of temperature. Moreover, the hybrid-circular-hole structure is propitious to selectively integrate different functional materials. Two different materials are integrated into this proposed MOF, the application of the Sagnac interferometer in temperature sensing is studied, and two groups of dips would be observed in the transmission spectra, which have different temperature sensitivities. Therefore, the proposed MOF can be used as a flexible temperature-insensitive polarization filter or potentially applied to a two-parameter sensor.
