目的应用3D技术和骨折地图技术将肱骨近端骨折患者的CT数据立体化,分析肱骨近端骨折线的分布特征,从而提高医师对该类骨折的认识及提供标准化骨折切割模型。方法回顾性分析162例患者肱骨近端骨折线的分布情况。应用Mimics Research 21....目的应用3D技术和骨折地图技术将肱骨近端骨折患者的CT数据立体化,分析肱骨近端骨折线的分布特征,从而提高医师对该类骨折的认识及提供标准化骨折切割模型。方法回顾性分析162例患者肱骨近端骨折线的分布情况。应用Mimics Research 21.0软件将所有数据进行三维重建,建立模型。将提取的三维模型导入到3-matic Research 13.0软件,复位骨折碎片后在E-3D medical 18.08软件中使其与3D模板完全重合,在模板表面绘制光滑曲线。将所有曲线叠加到模板上,生成三维骨折线图和热图。线性回归分析骨折位置与年龄、性别、患肢的左右侧的相关性。结果在生成的肱骨近端骨折热图上,红色区域集中分布于肱骨头基底、大结节基底、小结节基底、肱骨解剖颈。4部分骨折是最常见的类型,共87例(53.7%),单独绘制了4部分骨折的特征性骨折地图。累及大结节的红色条带沿着结节间沟外侧缘纵行向近端走行至大结节最高点,累及小结节的红色条带较宽,在小结节中下部横向延伸至肱骨头内侧基底,肱骨外科颈外侧出现3条红色细小条带向内侧环绕延伸。简单线性回归分析显示,性别和骨折位置显著相关(P<0.001),而与年龄、患肢的左右侧无相关性(P>0.05)。多元线性回归分析显示,在加入年龄后,性别与骨折位置的相关性更加显著(P<0.001)。结论4部分骨折在肱骨近端骨折中最常见,本研究构建了肱骨近端骨折地图,可提高医师对肱骨近端骨折的认识,提供标准化骨折切割模型,指导术前规划及术中操作。展开更多
目的研究T细胞型急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)患者HOX11L2基因的表达及其临床意义。方法采用回顾性分析方法对50例患者性别、年龄、白细胞数量、FAB分类(L1,L2 and L3)、分子生物学特点以及生存时间进行分析,...目的研究T细胞型急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)患者HOX11L2基因的表达及其临床意义。方法采用回顾性分析方法对50例患者性别、年龄、白细胞数量、FAB分类(L1,L2 and L3)、分子生物学特点以及生存时间进行分析,观察HOX11L2基因表达与临床特点及预后关系。结果50例T细胞型急性淋巴细胞白血病患者中,表达HOX11L2基因患者为12例(24%),其中男性7例(58.3%),女性5例(41.7%),HOX11L2基因表达者在男女性别之间的比较,差异无统计学意义(χ^2=0.119,P=0.730)。表达HOX11L2基因患者年龄在5~10岁间居多,表达率为58.3%,与其它年龄组之间的比较,差异有统计学意义(χ^2=11.577,P=0.018)。HOX11L2基因表达患者中白细胞计数≤50×10^9/L的患者10例(83.3%),白细胞计数>50×10^9/L的患者2例(16.7%),两组比较差异有统计学意义(χ^2=5.469,P=0.019)。FAB分类中,有75%的HOX11L2基因表达患者为L1型,与L2和L3组相比较,差异有统计学意义(χ^2=8.766,P=0.008)。其中34例获得随访资料的患者,HOX11L2基因表达组比非表达组生存时间短(中位生存时间分别为8.0个月和11.0个月),两组差异具有统计学意义(P<0.05)。结论研究结果表明HOX11L2基因主要表达于T-ALL患者,且以L1型儿童T-ALL为主,HOX11L2基因表达者预后不良,生存时间短。临床上通过HOX11L2基因检测结果与常规细胞形态学、遗传学、荧光原位杂交等技术检测结果相结合,将对急性淋巴细胞白血病的鉴别诊断、分型、预后及微小残留病检测等具有十分重要的意义。展开更多
Background One effect of solid tumors is severe hypoxia of local tissues. Heme oxygenase-1 （HO-1） is highly expressed in a variety of human tumor tissues; its induction and activity are closely related to growth of ...Background One effect of solid tumors is severe hypoxia of local tissues. Heme oxygenase-1 （HO-1） is highly expressed in a variety of human tumor tissues; its induction and activity are closely related to growth of solid tumors. Hypoxia inducible factor-1 （HIF-1） is a transcription factor that regulates hypoxia signal transduction and plays a central role in tumor hypoxia regulation. However, whether and how changes in HO-1 activity affect HIF-1 gene expression has not been reported previously. Methods Hypoxia-inducible models were established using gastric cancer cell lines （SGC-7901） in a hypoxia incubator. Cells were placed in four groups： Group A, transfected by plasmid harboring HO-1 shRNA; Group B, transfected with scrambled shRNA vector; Group C, treated with hemin; and Group D, exposed to hypoxia only. Expressions of HO-1 and HIF-1 mRNAs were quantified by reverse transcription-polymerase chain reaction. Expressions of HO-1 and HIF-1 proteins were determined by immunohistochemistry and Western blotting. Results mRNA and protein levels of HO-1 and HIF-1 in the control group were significantly higher than in Group A （P 〈0.01）, but lower than in Group C （P〈0.01）. Chromatin immunoprecipitation analysis showed that HIF-1 was identified as the direct HO-1 target gene. Conclusion While affected by HIF-1, HO-1 up-regulation promotes the expression of HIF-1 and the down-regulation of HO-1 suppresses the expression of HIF-1 gene.展开更多
The precision of profile and thickness is the most important target for wide strip rolling,but the coupling of profile control and thickness control is ignored in rolling schedule,which holds down the simultaneous qua...The precision of profile and thickness is the most important target for wide strip rolling,but the coupling of profile control and thickness control is ignored in rolling schedule,which holds down the simultaneous quality improvement of profile and thickness.A cross-coupled process control model for combined shape and gauge control was developed on the basis of the fact that both controls for profile and thickness are realized by controlling the rolling gap.A dynamic decoupling controller was then proposed to decouple the model.Both the simulation results and the online production data are valid and ensure the quality of the decoupling controller.展开更多
文摘目的应用3D技术和骨折地图技术将肱骨近端骨折患者的CT数据立体化,分析肱骨近端骨折线的分布特征,从而提高医师对该类骨折的认识及提供标准化骨折切割模型。方法回顾性分析162例患者肱骨近端骨折线的分布情况。应用Mimics Research 21.0软件将所有数据进行三维重建,建立模型。将提取的三维模型导入到3-matic Research 13.0软件,复位骨折碎片后在E-3D medical 18.08软件中使其与3D模板完全重合,在模板表面绘制光滑曲线。将所有曲线叠加到模板上,生成三维骨折线图和热图。线性回归分析骨折位置与年龄、性别、患肢的左右侧的相关性。结果在生成的肱骨近端骨折热图上,红色区域集中分布于肱骨头基底、大结节基底、小结节基底、肱骨解剖颈。4部分骨折是最常见的类型,共87例(53.7%),单独绘制了4部分骨折的特征性骨折地图。累及大结节的红色条带沿着结节间沟外侧缘纵行向近端走行至大结节最高点,累及小结节的红色条带较宽,在小结节中下部横向延伸至肱骨头内侧基底,肱骨外科颈外侧出现3条红色细小条带向内侧环绕延伸。简单线性回归分析显示,性别和骨折位置显著相关(P<0.001),而与年龄、患肢的左右侧无相关性(P>0.05)。多元线性回归分析显示,在加入年龄后,性别与骨折位置的相关性更加显著(P<0.001)。结论4部分骨折在肱骨近端骨折中最常见,本研究构建了肱骨近端骨折地图,可提高医师对肱骨近端骨折的认识,提供标准化骨折切割模型,指导术前规划及术中操作。
文摘目的研究T细胞型急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)患者HOX11L2基因的表达及其临床意义。方法采用回顾性分析方法对50例患者性别、年龄、白细胞数量、FAB分类(L1,L2 and L3)、分子生物学特点以及生存时间进行分析,观察HOX11L2基因表达与临床特点及预后关系。结果50例T细胞型急性淋巴细胞白血病患者中,表达HOX11L2基因患者为12例(24%),其中男性7例(58.3%),女性5例(41.7%),HOX11L2基因表达者在男女性别之间的比较,差异无统计学意义(χ^2=0.119,P=0.730)。表达HOX11L2基因患者年龄在5~10岁间居多,表达率为58.3%,与其它年龄组之间的比较,差异有统计学意义(χ^2=11.577,P=0.018)。HOX11L2基因表达患者中白细胞计数≤50×10^9/L的患者10例(83.3%),白细胞计数>50×10^9/L的患者2例(16.7%),两组比较差异有统计学意义(χ^2=5.469,P=0.019)。FAB分类中,有75%的HOX11L2基因表达患者为L1型,与L2和L3组相比较,差异有统计学意义(χ^2=8.766,P=0.008)。其中34例获得随访资料的患者,HOX11L2基因表达组比非表达组生存时间短(中位生存时间分别为8.0个月和11.0个月),两组差异具有统计学意义(P<0.05)。结论研究结果表明HOX11L2基因主要表达于T-ALL患者,且以L1型儿童T-ALL为主,HOX11L2基因表达者预后不良,生存时间短。临床上通过HOX11L2基因检测结果与常规细胞形态学、遗传学、荧光原位杂交等技术检测结果相结合,将对急性淋巴细胞白血病的鉴别诊断、分型、预后及微小残留病检测等具有十分重要的意义。
基金Supported in part by the National Natural Science Foundation of China under Grant Nos 107751000 and 10974137, and the Fund of Nuclear Theory Center of HIRFL of China.
文摘与限制潜力和混合相互作用，在 u 上混合介子的风味， d，和 s 夸克部门的苏(3 ) 风味基于轻锥的有效 Hamiltonian 被调查。混合向量和假向量介子的风味的集体 eigen 方程被解决。计算群众在对试验性的数据的好同意。[从作者抽象]
文摘Background One effect of solid tumors is severe hypoxia of local tissues. Heme oxygenase-1 （HO-1） is highly expressed in a variety of human tumor tissues; its induction and activity are closely related to growth of solid tumors. Hypoxia inducible factor-1 （HIF-1） is a transcription factor that regulates hypoxia signal transduction and plays a central role in tumor hypoxia regulation. However, whether and how changes in HO-1 activity affect HIF-1 gene expression has not been reported previously. Methods Hypoxia-inducible models were established using gastric cancer cell lines （SGC-7901） in a hypoxia incubator. Cells were placed in four groups： Group A, transfected by plasmid harboring HO-1 shRNA; Group B, transfected with scrambled shRNA vector; Group C, treated with hemin; and Group D, exposed to hypoxia only. Expressions of HO-1 and HIF-1 mRNAs were quantified by reverse transcription-polymerase chain reaction. Expressions of HO-1 and HIF-1 proteins were determined by immunohistochemistry and Western blotting. Results mRNA and protein levels of HO-1 and HIF-1 in the control group were significantly higher than in Group A （P 〈0.01）, but lower than in Group C （P〈0.01）. Chromatin immunoprecipitation analysis showed that HIF-1 was identified as the direct HO-1 target gene. Conclusion While affected by HIF-1, HO-1 up-regulation promotes the expression of HIF-1 and the down-regulation of HO-1 suppresses the expression of HIF-1 gene.
基金Item Sponsored by National Significant Technical Equipment Research and Development Project of 10th Five-Year-Plan of China(ZZ02-13B-03-03)
文摘The precision of profile and thickness is the most important target for wide strip rolling,but the coupling of profile control and thickness control is ignored in rolling schedule,which holds down the simultaneous quality improvement of profile and thickness.A cross-coupled process control model for combined shape and gauge control was developed on the basis of the fact that both controls for profile and thickness are realized by controlling the rolling gap.A dynamic decoupling controller was then proposed to decouple the model.Both the simulation results and the online production data are valid and ensure the quality of the decoupling controller.
