背景口服中药在慢性阻塞性肺疾病急性加重(AECOPD)的治疗中应用广泛,但相关临床试验的结局指标尚未得到统一和规范。目的通过筛选已发表的以口服中药为AECOPD治疗措施的随机对照试验(RCT),总结其文献特征和选用的结局指标情况,为中医药...背景口服中药在慢性阻塞性肺疾病急性加重(AECOPD)的治疗中应用广泛,但相关临床试验的结局指标尚未得到统一和规范。目的通过筛选已发表的以口服中药为AECOPD治疗措施的随机对照试验(RCT),总结其文献特征和选用的结局指标情况,为中医药治疗AECOPD临床试验设计和结局指标选择提供参考。方法计算机检索中国知网、万方数据知识服务平台、维普网、中国生物医学文献数据库、PubMed、Embase、Web of Science、Cochrane Library、ClinicalTrials.gov、中国临床试验注册中心,获取口服中药治疗AECOPD的RCT和临床试验注册方案,检索时限为2018年1月—2022年10月。由2位评价员独立筛选文献、提取资料后,采用定性分析的方法,对纳入研究的结局指标选择情况进行描述。结果纳入578篇文献,包含574篇已报告试验结果的RCT及4个临床试验注册方案。574篇RCT共纳入51508例患者。88篇文献在纳入标准中限定了患者的疾病分级,361篇文献在纳入标准中限定了中医证型,6篇文献报告了盲法,6篇文献提及了随访。纳入文献共涉及4030个结局指标,单篇文献结局指标数量范围为1~24个。按照结局指标的功能属性,将其归为8个指标域:中医症状/证候、症状/体征、理化检测、生活质量、远期预后、经济学评估、安全性评价、其他,报告率最高的指标域是理化检测,报告频次排名前5位的结局指标项目是:有效率(11.5%)、第1秒用力呼气容积(7.5%)、中医症状/证候评分(7.0%)、第1秒用力呼气容积/用力肺活量(6.8%)、用力肺活量(4.6%)。445篇文献报告了有效率的组成,报告率排名前5位的研究指标依次为症状(423篇)、体征(281篇)、中医证候评分(203篇)、实验室检查(89篇)、肺功能(71篇)。结论口服中药治疗AECOPD的RCT涉及的结局指标数量多、范围广,纳入的文献在不同程度上关注了口服中药对AECOPD患者的症状体征、理化检测指标、生活质量、远期预后、经济学评价和安全性结局等方面的影响。但结局指标的选择仍存在多方面的问题:结局指标主次不清;主要关注替代终点,对临床终点的关注不足;对卫生经济学指标关注不足;有效性参考来源不一、判断标准不一。研究者可参考已发表的核心指标集,合理设计结局指标,以提高中医药临床研究的质量。展开更多
This paper presents the results from laboratory experiments and theoretical analysis to investigate the development of scour around submarine pipeline under steady current conditions. Experiments show that the scour p...This paper presents the results from laboratory experiments and theoretical analysis to investigate the development of scour around submarine pipeline under steady current conditions. Experiments show that the scour process takes place in two stages: the initial rapid scour and the subsequent gradual scour development stage. An empirical formula for calculating the equilibrium scour depth(the maximum scour depth) is developed by using the regression method. This formula together with the maximum entropy theory can be applied to establish a formula to predict the scour process for given water depth, diameter of pipeline and flow velocity. Good agreement between the predicted and measured scour depth is obtained.展开更多
漆树(Toxicodendron vernicifluum (Stokes) F. A. Barkley)是中国重要的多年生落叶乔木,在生态群落保护和生物制药方面均有较高的利用价值,因此,具有重要的研究意义。本研究首先通过单因素试验确定了漆树SSR-PCR体系,进一步经正交试验...漆树(Toxicodendron vernicifluum (Stokes) F. A. Barkley)是中国重要的多年生落叶乔木,在生态群落保护和生物制药方面均有较高的利用价值,因此,具有重要的研究意义。本研究首先通过单因素试验确定了漆树SSR-PCR体系,进一步经正交试验对其SSR-PCR体系进行优化和筛选。通过PCR扩增筛选出7对条带清晰、多态性好的引物,7对引物最适退火温度分别是:57℃,55.6℃,58℃,57℃,56.8℃,56℃,58℃。基于建立的漆树SSR-PCR体系,利用选出的7对引物,对46个漆树样本进行遗传多样性及遗传结构分析,获得漆树种群内的观察等位基因平均数Na、有效等位基因数Ne、Shannon多样性指数I、Nei's基因多样性指数H分别为1.79、1.24、0.27、0.16,多态位点百分率PPB为88.72%,表明漆树种群内部具有丰富遗传多样性,AMOVA分子方差分析结果显示漆树种群内遗传变异74%高于种群间变异26%,表明种群内的遗传变异大于种群间。导致此种现象可能与漆树的传粉方式、种子特征和种子播撒机制以及环境抑制有一定的关系,本研究结果为合理开发利用漆树天然林,发掘其经济价值提供理论依据。展开更多
Turbulent flow in a 3-D blade passage of a Francis hydro turbine was simulated with the Large Eddy Simulation （LES） to investigate the spatial and temporal distributions of the turbulence when strongly distorted wak...Turbulent flow in a 3-D blade passage of a Francis hydro turbine was simulated with the Large Eddy Simulation （LES） to investigate the spatial and temporal distributions of the turbulence when strongly distorted wakes in the inflow sweep over the passage, In a suitable consideration of the energy exchanging mechanism between the large and small scales in the complicated passage with a strong 3-D curvature, one-coefficient dynamic Sub-Grid-Scale （SGS） stress model was used in this article. The simulations show that the strong wakes in the inflow lead to a flow separation at the leading zone of the passage, and to form a primary vortex in the span-wise direction. The primary span-wise vortex evolves and splits into smaller vortex pairs due to the constraint of no-slip wall condition, which triggers losing stability of the flow in the passage. The computed pressures on the pressure and suction sides agree with the measured data for a working test turbine model.展开更多
The Preissmann implicit scheme was used to discretize the one-dimensional Saint-Venant equations, the river-junction-fiver method was applied to resolve the hydrodynamic and water quality model for river networks, and...The Preissmann implicit scheme was used to discretize the one-dimensional Saint-Venant equations, the river-junction-fiver method was applied to resolve the hydrodynamic and water quality model for river networks, and the key issues on the model were expatiated particularly in this article. This water quality module was designed to compute time dependent concentrations of a series of constituents, which are primarily governed by the processes of advection, dispersion and chemical reactions. Based on the theory of Water Quality Analysis Simulation Program （WASP） water quality model, emphasis was given to the simulation of the biogeochemical transformations that determine the fate of nutrients, in particular, the simulation of the aquatic cycles of nitrogen and phosphorus compounds. This model also includes procedures for the determination of growth and death of phytoplankton. This hydrodynamic and water quality model was applied to calculate two river networks. As illustrated by the numerical examples, the calculated water level and discharge agree with the measured data and the simulated trends and magnitudes of water quality constituents are generally in good agreement with field observations. It is concluded that the presented model is useful in the pollutant control and in the determination of pollutant-related problems for river networks.展开更多
文摘背景口服中药在慢性阻塞性肺疾病急性加重(AECOPD)的治疗中应用广泛,但相关临床试验的结局指标尚未得到统一和规范。目的通过筛选已发表的以口服中药为AECOPD治疗措施的随机对照试验(RCT),总结其文献特征和选用的结局指标情况,为中医药治疗AECOPD临床试验设计和结局指标选择提供参考。方法计算机检索中国知网、万方数据知识服务平台、维普网、中国生物医学文献数据库、PubMed、Embase、Web of Science、Cochrane Library、ClinicalTrials.gov、中国临床试验注册中心,获取口服中药治疗AECOPD的RCT和临床试验注册方案,检索时限为2018年1月—2022年10月。由2位评价员独立筛选文献、提取资料后,采用定性分析的方法,对纳入研究的结局指标选择情况进行描述。结果纳入578篇文献,包含574篇已报告试验结果的RCT及4个临床试验注册方案。574篇RCT共纳入51508例患者。88篇文献在纳入标准中限定了患者的疾病分级,361篇文献在纳入标准中限定了中医证型,6篇文献报告了盲法,6篇文献提及了随访。纳入文献共涉及4030个结局指标,单篇文献结局指标数量范围为1~24个。按照结局指标的功能属性,将其归为8个指标域:中医症状/证候、症状/体征、理化检测、生活质量、远期预后、经济学评估、安全性评价、其他,报告率最高的指标域是理化检测,报告频次排名前5位的结局指标项目是:有效率(11.5%)、第1秒用力呼气容积(7.5%)、中医症状/证候评分(7.0%)、第1秒用力呼气容积/用力肺活量(6.8%)、用力肺活量(4.6%)。445篇文献报告了有效率的组成,报告率排名前5位的研究指标依次为症状(423篇)、体征(281篇)、中医证候评分(203篇)、实验室检查(89篇)、肺功能(71篇)。结论口服中药治疗AECOPD的RCT涉及的结局指标数量多、范围广,纳入的文献在不同程度上关注了口服中药对AECOPD患者的症状体征、理化检测指标、生活质量、远期预后、经济学评价和安全性结局等方面的影响。但结局指标的选择仍存在多方面的问题:结局指标主次不清;主要关注替代终点,对临床终点的关注不足;对卫生经济学指标关注不足;有效性参考来源不一、判断标准不一。研究者可参考已发表的核心指标集,合理设计结局指标,以提高中医药临床研究的质量。
基金financially supported by the National Nature Science Foundation of China (Grant No. 51279189)
文摘This paper presents the results from laboratory experiments and theoretical analysis to investigate the development of scour around submarine pipeline under steady current conditions. Experiments show that the scour process takes place in two stages: the initial rapid scour and the subsequent gradual scour development stage. An empirical formula for calculating the equilibrium scour depth(the maximum scour depth) is developed by using the regression method. This formula together with the maximum entropy theory can be applied to establish a formula to predict the scour process for given water depth, diameter of pipeline and flow velocity. Good agreement between the predicted and measured scour depth is obtained.
文摘漆树(Toxicodendron vernicifluum (Stokes) F. A. Barkley)是中国重要的多年生落叶乔木,在生态群落保护和生物制药方面均有较高的利用价值,因此,具有重要的研究意义。本研究首先通过单因素试验确定了漆树SSR-PCR体系,进一步经正交试验对其SSR-PCR体系进行优化和筛选。通过PCR扩增筛选出7对条带清晰、多态性好的引物,7对引物最适退火温度分别是:57℃,55.6℃,58℃,57℃,56.8℃,56℃,58℃。基于建立的漆树SSR-PCR体系,利用选出的7对引物,对46个漆树样本进行遗传多样性及遗传结构分析,获得漆树种群内的观察等位基因平均数Na、有效等位基因数Ne、Shannon多样性指数I、Nei's基因多样性指数H分别为1.79、1.24、0.27、0.16,多态位点百分率PPB为88.72%,表明漆树种群内部具有丰富遗传多样性,AMOVA分子方差分析结果显示漆树种群内遗传变异74%高于种群间变异26%,表明种群内的遗传变异大于种群间。导致此种现象可能与漆树的传粉方式、种子特征和种子播撒机制以及环境抑制有一定的关系,本研究结果为合理开发利用漆树天然林,发掘其经济价值提供理论依据。
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 50579025 and 90210005 ).
文摘Turbulent flow in a 3-D blade passage of a Francis hydro turbine was simulated with the Large Eddy Simulation （LES） to investigate the spatial and temporal distributions of the turbulence when strongly distorted wakes in the inflow sweep over the passage, In a suitable consideration of the energy exchanging mechanism between the large and small scales in the complicated passage with a strong 3-D curvature, one-coefficient dynamic Sub-Grid-Scale （SGS） stress model was used in this article. The simulations show that the strong wakes in the inflow lead to a flow separation at the leading zone of the passage, and to form a primary vortex in the span-wise direction. The primary span-wise vortex evolves and splits into smaller vortex pairs due to the constraint of no-slip wall condition, which triggers losing stability of the flow in the passage. The computed pressures on the pressure and suction sides agree with the measured data for a working test turbine model.
基金Project supported by the National Natural Science Foundation of China (Grant No.50839001)the National Basic Research Program of China (973 Program, Grant No. 2005CB724202).
文摘The Preissmann implicit scheme was used to discretize the one-dimensional Saint-Venant equations, the river-junction-fiver method was applied to resolve the hydrodynamic and water quality model for river networks, and the key issues on the model were expatiated particularly in this article. This water quality module was designed to compute time dependent concentrations of a series of constituents, which are primarily governed by the processes of advection, dispersion and chemical reactions. Based on the theory of Water Quality Analysis Simulation Program （WASP） water quality model, emphasis was given to the simulation of the biogeochemical transformations that determine the fate of nutrients, in particular, the simulation of the aquatic cycles of nitrogen and phosphorus compounds. This model also includes procedures for the determination of growth and death of phytoplankton. This hydrodynamic and water quality model was applied to calculate two river networks. As illustrated by the numerical examples, the calculated water level and discharge agree with the measured data and the simulated trends and magnitudes of water quality constituents are generally in good agreement with field observations. It is concluded that the presented model is useful in the pollutant control and in the determination of pollutant-related problems for river networks.
