目的探讨不同绒毛膜性双胎新生儿不良围产结局的检出率及影响因素。方法选取双胎妊娠产妇420例,根据绒毛膜性分为单绒毛膜组(MC组,n=116)和双绒毛膜组(DC组,n=304),比较2组产妇所产双胎新生儿不良围产结局[至少1个活产儿出现1种及以上情...目的探讨不同绒毛膜性双胎新生儿不良围产结局的检出率及影响因素。方法选取双胎妊娠产妇420例,根据绒毛膜性分为单绒毛膜组(MC组,n=116)和双绒毛膜组(DC组,n=304),比较2组产妇所产双胎新生儿不良围产结局[至少1个活产儿出现1种及以上情况:小于胎龄儿(SGA)、1 min Apgar评分低于7分、新生儿缺血缺氧性脑病(HIE)、新生儿呼吸窘迫综合征(NRDS)及新生儿死亡]和良好结局的发生情况;收集所有双胎新生儿临床资料(母亲年龄、是否初产、母体是否有产科并发症、母体是否有慢性疾病、是否胎膜早破、羊水量是否异常、脐血流是否异常、是否早产、分娩孕周、分娩方式、小儿与大儿体质量及体质量不一致性),分别采用单因素分析法和多因素logistic回归分析法分析MC组和DC组双胎妊娠产妇所产新生儿不良围产结局的影响因素。结果MC组双胎妊娠产妇所产新生儿不良围产结局的检出率(56.03%)高于DC组(44.74%),差异有统计学意义(χ^(2)=4.295,P=0.038);多因素logistic回归分析结果显示,非初产、脐血流异常、早产及双胎体质量不一致性≥20%为MC组双胎妊娠产妇所产新生儿不良围产结局的独立危险因素(OR=2.565、2.980、2.804、4.080,P<0.05),母体有产科并发症、早产、分娩方式为阴道分娩及双胎体质量不一致性≥20%为DC组双胎妊娠产妇所产新生儿不良围产结局的独立危险因素(OR=2.635、2.447、2.787、2.659,P<0.05)。结论与DC组比较,MC组双胎妊娠产妇双胎新生儿不良围产结局的检出率较高,且与初产、脐血流、早产及双胎体质量不一致性有关;DC双胎新生儿不良围产结局的发生则与母体产科并发症、早产、分娩方式及双胎体质量不一致性有关。展开更多
The present work shows drug-carrier interactions, release behaviors and cell responses of hydroxyapatite （HA） containing salvianolic acid B （Sal B）, astragalus polysaecharide （APS）, and naringin. X-ray diffracti...The present work shows drug-carrier interactions, release behaviors and cell responses of hydroxyapatite （HA） containing salvianolic acid B （Sal B）, astragalus polysaecharide （APS）, and naringin. X-ray diffraction （XRD） showed that the crystallinity and crystal size of HA decreased significantly when Sal B was added （p〈0.05）. Transmission electron microscope （TEM） confirmed that the nano-acicular crystals of HA containing Sal B were the most fine among all specimens. It was conjectured that Sal B preferentially adsorbed on the positively charged surface of HA crystals to inhibit their growth. In vitro release of HA containing Chinese medicines followed the first-order equation. The drug-carrier affinity between HA and Sal B might have prolonged the release of Sal B. The proliferation and differentiation of osteoblasts were promoted by Chinese medicines containing HA in the time and dosage dependent manner. The osteoblasts displayed a polygonal morphology with cell-cell junctions in all cases. It is suggested that the contained Chinese medicines would promote the activities of the osteoblasts.展开更多
从可持续发展战略角度考虑,降低市政设施的碳排放量是生态文明发展的重要一步。非开挖管道修复方式节能环保、绿色低碳,是管道修复行业升级转型的大趋势。结合四川省射洪市管网修复案例,对修复管道材料生产阶段、材料与设备运输阶段、...从可持续发展战略角度考虑,降低市政设施的碳排放量是生态文明发展的重要一步。非开挖管道修复方式节能环保、绿色低碳,是管道修复行业升级转型的大趋势。结合四川省射洪市管网修复案例,对修复管道材料生产阶段、材料与设备运输阶段、施工阶段进行了碳足迹追踪。结果表明:材料生产阶段碳排放量为11263.14 kg CO_(2)e,运输阶段碳排放量为134.78 kg CO_(2)e,施工阶段碳排放量为539.12 kg CO_(2)e,分别约占总碳排放量的94.35%、1.13%和4.52%。材料生产阶段碳排放量最大,是控制翻转式原位固化修复碳排放量的关键。对施工过程中材料与能源进行敏感性分析,发现树脂的敏感性最强,其次是无纺布,优化这2种材料或控制其使用量,将对降低翻转式原位固化工程的碳排放有重要作用。展开更多
文摘目的探讨不同绒毛膜性双胎新生儿不良围产结局的检出率及影响因素。方法选取双胎妊娠产妇420例,根据绒毛膜性分为单绒毛膜组(MC组,n=116)和双绒毛膜组(DC组,n=304),比较2组产妇所产双胎新生儿不良围产结局[至少1个活产儿出现1种及以上情况:小于胎龄儿(SGA)、1 min Apgar评分低于7分、新生儿缺血缺氧性脑病(HIE)、新生儿呼吸窘迫综合征(NRDS)及新生儿死亡]和良好结局的发生情况;收集所有双胎新生儿临床资料(母亲年龄、是否初产、母体是否有产科并发症、母体是否有慢性疾病、是否胎膜早破、羊水量是否异常、脐血流是否异常、是否早产、分娩孕周、分娩方式、小儿与大儿体质量及体质量不一致性),分别采用单因素分析法和多因素logistic回归分析法分析MC组和DC组双胎妊娠产妇所产新生儿不良围产结局的影响因素。结果MC组双胎妊娠产妇所产新生儿不良围产结局的检出率(56.03%)高于DC组(44.74%),差异有统计学意义(χ^(2)=4.295,P=0.038);多因素logistic回归分析结果显示,非初产、脐血流异常、早产及双胎体质量不一致性≥20%为MC组双胎妊娠产妇所产新生儿不良围产结局的独立危险因素(OR=2.565、2.980、2.804、4.080,P<0.05),母体有产科并发症、早产、分娩方式为阴道分娩及双胎体质量不一致性≥20%为DC组双胎妊娠产妇所产新生儿不良围产结局的独立危险因素(OR=2.635、2.447、2.787、2.659,P<0.05)。结论与DC组比较,MC组双胎妊娠产妇双胎新生儿不良围产结局的检出率较高,且与初产、脐血流、早产及双胎体质量不一致性有关;DC双胎新生儿不良围产结局的发生则与母体产科并发症、早产、分娩方式及双胎体质量不一致性有关。
基金Funded by National Basic Research Program of China (973 Program) (No.2012CB933602)National Natural Science Foundation of China (No.50975239)+1 种基金the Key Project of Chinese Ministry of Education (No.109137)the Fundamental Research Funds for the Central Universities (Nos.SWJTU11CX118 and SWJTU11ZT05)
文摘The present work shows drug-carrier interactions, release behaviors and cell responses of hydroxyapatite （HA） containing salvianolic acid B （Sal B）, astragalus polysaecharide （APS）, and naringin. X-ray diffraction （XRD） showed that the crystallinity and crystal size of HA decreased significantly when Sal B was added （p〈0.05）. Transmission electron microscope （TEM） confirmed that the nano-acicular crystals of HA containing Sal B were the most fine among all specimens. It was conjectured that Sal B preferentially adsorbed on the positively charged surface of HA crystals to inhibit their growth. In vitro release of HA containing Chinese medicines followed the first-order equation. The drug-carrier affinity between HA and Sal B might have prolonged the release of Sal B. The proliferation and differentiation of osteoblasts were promoted by Chinese medicines containing HA in the time and dosage dependent manner. The osteoblasts displayed a polygonal morphology with cell-cell junctions in all cases. It is suggested that the contained Chinese medicines would promote the activities of the osteoblasts.
文摘从可持续发展战略角度考虑,降低市政设施的碳排放量是生态文明发展的重要一步。非开挖管道修复方式节能环保、绿色低碳,是管道修复行业升级转型的大趋势。结合四川省射洪市管网修复案例,对修复管道材料生产阶段、材料与设备运输阶段、施工阶段进行了碳足迹追踪。结果表明:材料生产阶段碳排放量为11263.14 kg CO_(2)e,运输阶段碳排放量为134.78 kg CO_(2)e,施工阶段碳排放量为539.12 kg CO_(2)e,分别约占总碳排放量的94.35%、1.13%和4.52%。材料生产阶段碳排放量最大,是控制翻转式原位固化修复碳排放量的关键。对施工过程中材料与能源进行敏感性分析,发现树脂的敏感性最强,其次是无纺布,优化这2种材料或控制其使用量,将对降低翻转式原位固化工程的碳排放有重要作用。
