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LC-MS/MS法监控阿齐沙坦原料中带警示结构的叠氮化杂质残留风险 被引量:1
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作者 郭招娣 赵甜 +6 位作者 许红霞 郭鑫 赵小君 谌宗永 马昂 刘宇晶 王明娟 《药品评价》 CAS 2023年第7期807-810,共4页
目的建立可监控阿齐沙坦原料中具有警示结构的叠氮化杂质AMBC含量的方法。方法采用AB SCIEX 4000APILC-MS/MS串联质谱系统,ACE Excel 3 C18柱(150 mm×4.6 mm,3μm),柱温40℃,流动相A为0.01 mol/L乙酸铵水溶液-乙腈(90∶10),流动相... 目的建立可监控阿齐沙坦原料中具有警示结构的叠氮化杂质AMBC含量的方法。方法采用AB SCIEX 4000APILC-MS/MS串联质谱系统,ACE Excel 3 C18柱(150 mm×4.6 mm,3μm),柱温40℃,流动相A为0.01 mol/L乙酸铵水溶液-乙腈(90∶10),流动相B为乙腈,梯度洗脱,总流速:0.5 mL/min。串联质谱的参数设置:大气压化学电离-正电离模式(APCI+),多反应监测模式(MRM),用207.3→180.3离子对定量监测化合物AMBC的残留量,探头温度:450℃,电晕针电流:3.0μA,气帘气:35 psi,碰撞气:4 psi,雾化气:45 psi,采集时间:16 min。结果采用拟定方法测得的AMBC检测限和定量限分别为0.062 ng/mL和0.21 ng/mL(相当于0.07,远低于其杂质限37.5);在10.4~312.2ng/mL范围内,AMBC呈良好的线性响应(r=0.9998),方法的加样回收率介于100.2%~104.2%。结论该方法灵敏度高、准确性好、专属性强,在覆盖限度的较宽范围内均呈良好的线性响应,能用于阿齐沙坦原料中具有警示结构的叠氮杂质AMBC的残留风险监控。 展开更多
关键词 药物污染 阿齐沙坦 基因毒性杂质 警示结构 叠氮化物 串联质谱 痕量检测 残留风险
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双层人工真皮联合自体皮片移植修复手指皮肤软组织缺损伴骨、肌腱暴露创面的效果 被引量:9
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作者 李明 郭招娣 +2 位作者 汪炜 陈冬生 李涛 《组织工程与重建外科》 CAS 2022年第4期322-327,共6页
目的 研究双层人工真皮联合自体皮片移植,修复手指皮肤软组织缺损伴骨、肌腱暴露创面的临床效果。方法回顾性分析2020年9月至2021年10月收治的手指皮肤软组织缺损伴骨、肌腱暴露患者43例。使用双层人工真皮联合自体皮片移植者为观察组(n... 目的 研究双层人工真皮联合自体皮片移植,修复手指皮肤软组织缺损伴骨、肌腱暴露创面的临床效果。方法回顾性分析2020年9月至2021年10月收治的手指皮肤软组织缺损伴骨、肌腱暴露患者43例。使用双层人工真皮联合自体皮片移植者为观察组(n=16),使用带蒂皮瓣移植者为对照组(n=27)。观察比较两组患者治疗情况,包括两次手术间隔时间、皮片/皮瓣成活率和住院时间。术后3个月应用温哥华瘢痕量表(VSS)进行瘢痕评分;分别于术前、术后1、3个月对手指感觉恢复情况进行评分,并于术后3个月进行两点分辨觉测试。结果 对照组两次手术间隔时间、住院时间明显较观察组长(P<0.05),但两组患者皮片/皮瓣成活率无统计学差异(P>0.05)。术后3个月,患者均恢复良好,无明显皮片破溃表现。VSS评分结果显示,两组患者的修复部位色泽、血管分布及柔软度等无统计学差异(P>0.05),观察组厚度明显小于对照组(P<0.05)。观察组术后1、3个月时的感觉恢复评分明显高于对照组(P<0.05);两组术后1、3个月感觉恢复评分明显高于术前,术后3个月评分高于术后1个月(P<0.05)。术后3个月时两组患者的两点分辨觉无明显差异(P>0.05)。结论 双层人工真皮联合自体皮片移植可有效修复手指小面积皮肤软组织缺损伴骨、肌腱暴露创面,国产双层人工真皮Lando较带蒂皮瓣移植修复术后恢复快,手指外形更美观,为临床修复此类创面提供了新的选择。 展开更多
关键词 双层人工真皮 自体皮片移植 肌腱外露 骨质外露
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CG-LTDR卫星气候数据集及其在中亚地区的应用 被引量:1
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作者 张艳 唐世浩 +6 位作者 王勇 郭兆迪 张青 殷克勤 周立平 屈新原 李悦 《沙漠与绿洲气象》 2017年第2期21-26,共6页
全球及中国区域长时间序列卫星数据集(CG-LTDR)包括地表反照率、叶面积指数、土地覆盖分类、植被指数和积雪覆盖产品。为了应用CG-LTDR和其他卫星气候数据,基于WEBGIS技术建立了CG-LTDR系统,实现对卫星气候数据集的在线管理和显示分析... 全球及中国区域长时间序列卫星数据集(CG-LTDR)包括地表反照率、叶面积指数、土地覆盖分类、植被指数和积雪覆盖产品。为了应用CG-LTDR和其他卫星气候数据,基于WEBGIS技术建立了CG-LTDR系统,实现对卫星气候数据集的在线管理和显示分析功能。本文介绍了CG-LTDR卫星气候数据集及显示分析系统,并利用NDVI数据对中亚及周边核心区的植被状况和长期变化进行分析。结果表明:哈萨克斯坦、吉尔吉斯斯坦和塔吉克斯坦地区及新疆西部和北部植被平均状况较好。中亚地区的植被在20世纪90年代和2000年代整体状况较好,20世纪80年代相对较差,2010年后空间变化不均。特别是从21世纪开始我国西部沙漠化程度加重,一些地区地表植被严重破坏,生态环境变化不容乐观。由于中亚地区常规观测少,利用CG-LTDR卫星气候数据集对中亚地区进行应用具有很好的意义,CG-LTDR可以为农牧资源和生态环境提供有效信息。 展开更多
关键词 卫星气候数据 中亚 植被变化
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具有杆间弹性支撑的端部固定压杆稳定性研究
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作者 陈廷国 郭召迪 王祖能 《大连理工大学学报》 CAS CSCD 北大核心 2022年第6期618-625,共8页
为了研究具有杆间弹性支撑的端部固定压杆稳定性问题,首先简化工程模型为理论模型,求解两端固定压杆稳定承载力与杆间弹性支撑刚度的理论关系,并提出简化计算公式;其次根据理论模型,使用杆间弹簧支撑轴心压杆进行失稳试验,调整弹簧数量... 为了研究具有杆间弹性支撑的端部固定压杆稳定性问题,首先简化工程模型为理论模型,求解两端固定压杆稳定承载力与杆间弹性支撑刚度的理论关系,并提出简化计算公式;其次根据理论模型,使用杆间弹簧支撑轴心压杆进行失稳试验,调整弹簧数量以改变弹性支撑刚度,进行5组不同弹性支撑刚度下的杆件稳定承载力试验,通过试验结果验证理论解的正确性;最后使用ABAQUS进行有限元分析,计算杆间不同弹性支撑刚度下压杆的稳定承载力,对理论解进行验证.通过试验以及有限元分析验证了理论解的正确性,为工程设计人员提供了简单可靠的计算公式. 展开更多
关键词 压杆 两端固定 弹性支撑 稳定性 有限元分析
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2005-2015年中国及境内典型城市群甲醛柱浓度时空变化及影响因子分析 被引量:3
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作者 刘旭艳 高浩 +5 位作者 张倩倩 梁林林 张兴赢 郭兆迪 邓运超 白薇 《环境科学学报》 CAS CSCD 北大核心 2020年第8期2851-2868,共18页
基于2005-2015年OMI反演的甲醛柱浓度月均数据,对中国及境内典型城市群甲醛柱浓度时空变化及影响因子进行了分析.结果发现,甲醛柱浓度高值区集中在京津冀中南部、山东西部、河南北部、江浙沪、珠三角、湖北东部、湖南东部、广西、四川... 基于2005-2015年OMI反演的甲醛柱浓度月均数据,对中国及境内典型城市群甲醛柱浓度时空变化及影响因子进行了分析.结果发现,甲醛柱浓度高值区集中在京津冀中南部、山东西部、河南北部、江浙沪、珠三角、湖北东部、湖南东部、广西、四川与重庆交界.2005-2015年中国甲醛柱浓度总体呈上升趋势,其中,京津冀地区增长趋势最明显,江浙沪地区呈略微下降趋势.中国、京津冀及江浙沪地区夏季甲醛柱浓度明显高于其余3个季节,呈明显的周期性变化;2005-2015年中国4个季节甲醛柱浓度均呈增加趋势,京津冀地区除夏季外其余3个季节也呈增加趋势,江浙沪和珠三角地区各季节甲醛柱浓度变化趋势不一致.近11年,中国、京津冀和江浙沪地区7月甲醛柱浓度最高,珠三角地区9月甲醛柱浓度最高.京津冀和江浙沪地区甲醛柱浓度月最高值和月最低值之间的差异大于珠三角地区.中国、京津冀、江浙沪和珠三角地区近11年秸秆焚烧与相应甲醛柱浓度呈明显正相关,相关系数为0.84~1.00,表明秸秆焚烧是影响近11年甲醛柱浓度变化的重要因子.尽管有些区域季节温度与相应甲醛柱浓度呈负相关,但温度总体也是影响中国及这3个典型城市群甲醛柱浓度变化的另一个重要因子,京津冀地区尤其明显.月平均温度与相应甲醛柱浓度的相关系数为0.52~0.85.人口、民用汽车保有量和国内生产总值与中国、京津冀、江浙沪和珠三角地区相应甲醛柱浓度相关系数均低于0.60.影响因子分析结果暗示控制秸秆焚烧和减少温室效应是降低我国甲醛柱浓度的重要途径. 展开更多
关键词 甲醛柱浓度 OMI 时空变化 影响因子 城市群
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Spatio-temporal changes in biomass carbon sinks in China's forests from 1977 to 2008 被引量:52
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作者 guo zhaodi HU HuiFeng +2 位作者 LI Pin LI NuYun FANG JingYun 《Science China(Life Sciences)》 SCIE CAS 2013年第7期661-671,1,共11页
Forests play a leading role in regional and global carbon (C) cycles. Detailed assessment of the temporal and spatial changes in C sinks/sources of China's forests is critical to the estimation of the national C b... Forests play a leading role in regional and global carbon (C) cycles. Detailed assessment of the temporal and spatial changes in C sinks/sources of China's forests is critical to the estimation of the national C budget and can help to constitute sustainable forest management policies for climate change. In this study, we explored the spatio-temporal changes in forest biomass C stocks in China between 1977 and 2008, using six periods of the national forest inventory data. According to the definition of the forest inventory, China's forest was categorized into three groups: forest stand, economic forest, and bamboo forest. We estimated forest biomass C stocks for each inventory period by using continuous biomass expansion factor (BEF) method for forest stands, and the mean biomass density method for economic and bamboo forests. As a result, China's forests have accumulated biomass C (i.e., biomass C sink) of 1896 Tg (1Tg=1012g) during the study period, with 1710, 108 and 78 Tg C in forest stands, and economic and bamboo forests, respectively. Annual forest biomass C sink was 70.2 Tg Ca-1 , offsetting 7.8% of the contemporary fossil CO2 emissions in the country. The results also showed that planted forests have functioned as a persistent C sink, sequestrating 818 Tg C and accounting for 47.8% of total C sink in forest stands, and that the old-, mid- and young-aged forests have sequestrated 930, 391 and 388 Tg C from 1977 to 2008. Our results suggest that China's forests have a big potential as biomass C sink in the future because of its large area of planted forests with young-aged growth and low C density. 展开更多
关键词 中国森林 生物量碳 时空变化 森林资源清查 二氧化碳排放量 森林生物量 经济林 国家预算
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Biomass carbon stocks in China's forests between 2000 and 2050:A prediction based on forest biomass-age relationships 被引量:64
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作者 XU Bing guo zhaodi +1 位作者 PIAO ShiLong FANG JingYun 《Science China(Life Sciences)》 SCIE CAS 2010年第7期776-783,共8页
China's forests are characterized by young forest age,low carbon density and a large area of planted forests,and thus have high potential to act as carbon sinks in the future.Using China's national forest inve... China's forests are characterized by young forest age,low carbon density and a large area of planted forests,and thus have high potential to act as carbon sinks in the future.Using China's national forest inventory data during 1994-1998 and 1999-2003,and direct field measurements,we investigated the relationships between forest biomass density and forest age for 36 major forest types.Statistical approaches and the predicted future forest area from the national forestry development plan were applied to estimate the potential of forest biomass carbon storage in China during 2000-2050.Under an assumption of continuous natural forest growth,China's existing forest biomass carbon(C) stock would increase from 5.86 Pg C(1 Pg=1015 g) in 1999-2003 to 10.23 Pg C in 2050,resulting in a total increase of 4.37 Pg C.Newly planted forests through afforestation and reforestation will sequestrate an additional 2.86 Pg C in biomass.Overall,China's forests will potentially act as a carbon sink for 7.23 Pg C during the period 2000-2050,with an average carbon sink of 0.14 Pg C yr-1.This suggests that China's forests will be a significant carbon sink in the next 50 years. 展开更多
关键词 forest biomass-age relationship carbon pool carbon sink forest inventory data forest volume
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Scenario analysis on the global carbon emissions reduction goal proposed in the declaration of the 2009 G8 Summit 被引量:8
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作者 FANG JingYun WANG ShaoPeng +4 位作者 YUE Chao ZHU JiangLing guo zhaodi HE CanFei TANG ZhiYao 《Science China Earth Sciences》 SCIE EI CAS 2009年第11期1694-1702,共9页
A goal of a 50% reduction in global greenhouse gases emissions by 2050, with an 80% reduction by developed countries (hereafter referred to as the G8 Goal), was proposed at the G8 Summit held in L’Aquila, Italy, in J... A goal of a 50% reduction in global greenhouse gases emissions by 2050, with an 80% reduction by developed countries (hereafter referred to as the G8 Goal), was proposed at the G8 Summit held in L’Aquila, Italy, in July 2009. Here we analyze the scientific and political implications of the G8 Goal and its equity and feasibility by examining four greenhouse gas emissions scenarios. Our results show that (1) the goal to keep atmospheric CO2 concentration of <450 ppmv, stated by G8 nations, can only be achieved under the scenario of a steady, linear emissions reduction by all countries and simultaneously meeting the G8 Goal during the period 2005-2050; (2) under the G8 Goal, the carbon emissions quota for developing countries would not meet their carbon emission demands even if very strict reduction regimes are followed, with a gap of up to >1/3 of emissions demand in the next 45 years; and (3) under the G8 Goal, the cumulative per capita emissions during the period of 2006-2050 for developed and developing countries will be 81 t C and 40-47 t C, respectively, with the former doubling that of the latter, implying that the historical disparity of carbon emissions between developed and developing countries would be widened. Historically, the cumulative per capita emissions from developed countries are 12 times of those from developing countries. We therefore conclude that (1) the G8 Goal seeks to impose binding reduction targets on developing countries that will impede their industrialization process and cause conflicts among developing countries in the allocation of carbon emission rights; (2) the G8 Goal will not only widen the existing disparities of historical carbon emissions between developed and developing countries, but also generate new inequalities in the rights of carbon emissions; and (3) the 450 ppmv threshold of atmospheric CO2 concentration control, which is the basis for the G8 Goal, is impractical and impossible, and should not be accepted as the foundation for international climate negotiation on carbon emission reduction. In summary, the G8 Goal is clearly against the principle of "common but differentiated responsibilities" and thus is unacceptable for developing countries. 展开更多
关键词 CO2 EMISSION developed COUNTRIES developing COUNTRIES GLOBAL EMISSION reduction GOAL scenario analysis
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Wisdom and Knowledge: The Outline of Eastern and Western Aesthetic Spirits
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作者 guo zhaodi 《Frontiers of Philosophy in China》 2012年第1期90-111,共22页
Wisdom and knowledge are the basic spirits of Eastern and Western aesthetics. The shortcoming of the aesthetics based on knowledge, i.e., the aesthetics of knowledge, lies in the fact that it clings to the opposing di... Wisdom and knowledge are the basic spirits of Eastern and Western aesthetics. The shortcoming of the aesthetics based on knowledge, i.e., the aesthetics of knowledge, lies in the fact that it clings to the opposing differences between Western- and Eastern-centered theories. These differences include essentialism and anti-essentialism; harmonious and non-harmonious relationships between person, self, nature and society; art or nature as the highest aesthetic realm; metaphysics or psychology as the aesthetic domain; dualism and Advaita; and so on. The aesthetics based on wisdom, namely aesthetics of wisdom, is valuable due to its adopting an impartial attitude toward Eastern and Western aesthetics, essentialism and anti-essentialism, philosophical horizon and psychological horizon, theory of harmony and theory of antagonism, beauty of art and beauty of nature, dualism and Advaita, up to aesthetics of knowledge and aesthetics of wisdom. Contrasted with this understanding of the aesthetics of knowledge, non-dualism and non-Advaita are the soul of the spirit of the aesthetics of wisdom. 展开更多
关键词 Eastern aesthetics Western aesthetics aesthetics of wisdom aesthetics of knowledge academic spirit
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