Studies on Reaction Mechanism Between Sparfloxacin and Bovine Serum Albumin

The binding of sparfloxacin and bovine serum albumin(BSA) in aqueous solution was studied by means of fluorescence and absorbance spectra, and the interactions influenced by Fe 3+ and Cu 2+ were explored. Based on the Scatchard′s site binding model and fluorescence quenching, practical formulas for a small molecule ligand attaching to a bio-macromolecule are proposed. The binding parameters were measured according to the suggested models, and the binding distance, the transfer efficiency of energy between sparfloxacin and BSA were obtained in view of the Frster theory of non-radiation energy transfer. The effect of sparfloxacin on the conformation of BSA was analyzed by means of synchronous fluorescence spectroscopy.

生成式AI时代交互范式与人机关系的重构——从图形控件交互到自然交互

生成式人工智能应用的流行推动了自然交互范式的勃兴,该范式允许用户使用自然语言与人工智能展开多轮对话以满足用户需求。人机交互范式的变革是由技术革新作为内因以及社会需求转向作为外因所驱动的。自然交互范式具有三大特征,其一是人类调度机器的粒度加细,其二是人机交互的信息通量加大,其三是自然交互更加符合人类直觉。自然交互范式将驱动人机关系的深刻变革,首先自然交互将加深技术具身关系,促进机器与人类身心的融合;其次自然交互将驱动社会信息传播生态中机器超越“分发把关”演化为“价值把关”;最后自然交互将促进机器智能的涌现,从而使人类智能与机器智能呈现出双向发展的特征。