Background: To investigate the feasibility of single reshaped Judkins left catheter for transradial coronary angiography. Methods: A total of 198 consecutive patients were enrolled in the first step study. Patients we...Background: To investigate the feasibility of single reshaped Judkins left catheter for transradial coronary angiography. Methods: A total of 198 consecutive patients were enrolled in the first step study. Patients were randomly assigned to brachial type catheter group (BRACT group) or Judkins left catheter group (Judkins group). The inclusion criterion was the left coronary angiography which could be accomplished by either a brachial type catheter or a reshaped Judkins left catheter. The successful procedure was defined as both right and left coronary angiography could be completed with a single reshaped Judkins left catheter or a brachial type catheter. Furthermore, 1873 consecutive patients were continuously enrolled to observe the success rate of single Judkins left catheter for transradial coronary angiography. Results: Of the 198 patients, 191 were finally enrolled in this study according to the inclusion criteria, with 95 patients in BRACT group and96 inJudkins group. There were no significant differences on baseline between the two groups. Procedure success rate was 84.10% with a fluoroscopic exposure time of 3.81 ± 0.43 min in BRA-CT group, and 81.60% with a fluoroscopic exposure time of 4.05 ± 0.48 min in Judkins group (P > 0.05). No severe complications were found in either of the two groups. The success rates of 1869 patients with single Judkins left catheter for transradial coronary angiography were 75.33%. There were no complications in those patients. Conclusions: Transradial coronary angiography with a reshaped single Judkins left catheter is feasible and practical, with an accepted procedure success rate. This method should be worthy of further clinical validation in a larger scale population.展开更多
When light propagates through the edge or middle part of a microparticle’s incoming interface,there is a basic rule that light converges and diverges rapidly or slowly at the output port. These two parts are referred...When light propagates through the edge or middle part of a microparticle’s incoming interface,there is a basic rule that light converges and diverges rapidly or slowly at the output port. These two parts are referred to as the region of rapid change (RRC) and region of slow change (RSC),respectively. Finding the boundary point between RRC and RSC is the key to reveal and expound upon this rule scientifically. Based on the correlation between light convergence–divergence and the slope of emergent light,combined with the relationship between a natural logarithm and growth in physical reality and the second derivative of a function in practical significance,we determine the boundary point between RRC and RSC,namely,the inflection point. From such a perspective,a photonic nanojet (PNJ) and near-field focusing by light irradiation on RSC and RRC,as well as the position of the inflection point under different refractive index contrasts and the field distribution of light focusing,are studied with finite-element-method-based numerical simulation and ray-optics-based theoretical analysis. By illuminating light of different field intensity ratios to the regions divided by the inflection point,we demonstrate the generation of a photonic hook (PH) and the modulation of PNJ/PH in a new manner.展开更多
With continually improving reperfusion strategies and patient care,the overall mortality of acute myocardial infarction(AMI)has been significantly reduced during the past two decades.However,this success is a double-e...With continually improving reperfusion strategies and patient care,the overall mortality of acute myocardial infarction(AMI)has been significantly reduced during the past two decades.However,this success is a double-edged sword,as many patients surviving an AMI will progress towards ischemic heart failure(HF)over time.The pathologic causes of ischemic HF are undoubtedly multifactorial.However,the inflammatory response is considered one of the most important causes of pathological remodeling because it spans the whole process of HF development.The macrophage-mediated inflammatory response was once considered a purely harmful factor leading to pathological remodeling and HF.However,growing evidence demonstrates that multiple subgroups of macrophage exist and contribute differently to ischemic HF development.Understanding macrophage populations and how they contribute to post-MI remodeling and consequent ischemic HF is,therefore,critical to understanding and treating the disease.This review focuses on different macrophage populations that regulate post-MI cardiac injury and how immunoregulation therapy may benefit patients with ischemic HF.展开更多
文摘Background: To investigate the feasibility of single reshaped Judkins left catheter for transradial coronary angiography. Methods: A total of 198 consecutive patients were enrolled in the first step study. Patients were randomly assigned to brachial type catheter group (BRACT group) or Judkins left catheter group (Judkins group). The inclusion criterion was the left coronary angiography which could be accomplished by either a brachial type catheter or a reshaped Judkins left catheter. The successful procedure was defined as both right and left coronary angiography could be completed with a single reshaped Judkins left catheter or a brachial type catheter. Furthermore, 1873 consecutive patients were continuously enrolled to observe the success rate of single Judkins left catheter for transradial coronary angiography. Results: Of the 198 patients, 191 were finally enrolled in this study according to the inclusion criteria, with 95 patients in BRACT group and96 inJudkins group. There were no significant differences on baseline between the two groups. Procedure success rate was 84.10% with a fluoroscopic exposure time of 3.81 ± 0.43 min in BRA-CT group, and 81.60% with a fluoroscopic exposure time of 4.05 ± 0.48 min in Judkins group (P > 0.05). No severe complications were found in either of the two groups. The success rates of 1869 patients with single Judkins left catheter for transradial coronary angiography were 75.33%. There were no complications in those patients. Conclusions: Transradial coronary angiography with a reshaped single Judkins left catheter is feasible and practical, with an accepted procedure success rate. This method should be worthy of further clinical validation in a larger scale population.
基金Guangdong Basic and Applied Basic Research Foundation (2019A1515011242)Key-Area Research and Development Program of Guangdong Province(2019B020226004)+2 种基金National Natural Science Foundation of China (61805271,62074155)Shenzhen Science and Technology Innovation Commission(JCYJ20170818154035069,KCXFZ202002011008124)CAS Key Laboratory of Health Informatics (2011DP173015)。
文摘When light propagates through the edge or middle part of a microparticle’s incoming interface,there is a basic rule that light converges and diverges rapidly or slowly at the output port. These two parts are referred to as the region of rapid change (RRC) and region of slow change (RSC),respectively. Finding the boundary point between RRC and RSC is the key to reveal and expound upon this rule scientifically. Based on the correlation between light convergence–divergence and the slope of emergent light,combined with the relationship between a natural logarithm and growth in physical reality and the second derivative of a function in practical significance,we determine the boundary point between RRC and RSC,namely,the inflection point. From such a perspective,a photonic nanojet (PNJ) and near-field focusing by light irradiation on RSC and RRC,as well as the position of the inflection point under different refractive index contrasts and the field distribution of light focusing,are studied with finite-element-method-based numerical simulation and ray-optics-based theoretical analysis. By illuminating light of different field intensity ratios to the regions divided by the inflection point,we demonstrate the generation of a photonic hook (PH) and the modulation of PNJ/PH in a new manner.
文摘With continually improving reperfusion strategies and patient care,the overall mortality of acute myocardial infarction(AMI)has been significantly reduced during the past two decades.However,this success is a double-edged sword,as many patients surviving an AMI will progress towards ischemic heart failure(HF)over time.The pathologic causes of ischemic HF are undoubtedly multifactorial.However,the inflammatory response is considered one of the most important causes of pathological remodeling because it spans the whole process of HF development.The macrophage-mediated inflammatory response was once considered a purely harmful factor leading to pathological remodeling and HF.However,growing evidence demonstrates that multiple subgroups of macrophage exist and contribute differently to ischemic HF development.Understanding macrophage populations and how they contribute to post-MI remodeling and consequent ischemic HF is,therefore,critical to understanding and treating the disease.This review focuses on different macrophage populations that regulate post-MI cardiac injury and how immunoregulation therapy may benefit patients with ischemic HF.
