Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) infection can progress to a severe respiratory and systemic disease named coronavirus disease–2019(COVID-19). The most common symptoms are fever and respira...Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) infection can progress to a severe respiratory and systemic disease named coronavirus disease–2019(COVID-19). The most common symptoms are fever and respiratory discomfort. Nevertheless, gastrointestinal infections have been reported, with symptoms such as diarrhea, nausea, vomiting, abdominal pain, and lack of appetite. Importantly, SARS-CoV-2 can remain positive in fecal samples after nasopharyngeal clearance. After gastrointestinal SARS-CoV-2 infection and other viral gastrointestinal infections, some patients may develop alterations in the gastrointestinal microbiota. In addition, some COVID-19 patients may receive antibiotics, which may also disturb gastrointestinal homeostasis. In summary, the gastrointestinal system, gut microbiome, and gut-lung axis may represent an important role in the development, severity, and treatment of COVID-19. Therefore, in this review, we explore the current pieces of evidence of COVID-19 gastrointestinal manifestations, possible implications, and interventions.展开更多
The recent manuscript entitled“Relationship between clinical features and intestinal microbiota in Chinese patients with ulcerative colitis”reported a difference in the intestinal microbiota of patients with ulcerat...The recent manuscript entitled“Relationship between clinical features and intestinal microbiota in Chinese patients with ulcerative colitis”reported a difference in the intestinal microbiota of patients with ulcerative colitis according to the severity of the colitis.The influence of the intestinal microbiota on the development and progress of gastrointestinal disorders is well established.Besides the diversity in the microbiome,the presence of virulence factors and toxins by commensal bacteria may affect an extensive variety of cellular processes,contributing to the induction of a proinflammatory environment.展开更多
The recent manuscript reviewed investigations involving liver damage in coronavirus disease 2019(COVID-19)patients,and COVID-19 in patients with previous chronic hepatological diseases,such as patients with liver graf...The recent manuscript reviewed investigations involving liver damage in coronavirus disease 2019(COVID-19)patients,and COVID-19 in patients with previous chronic hepatological diseases,such as patients with liver graft.The literature presents several conflicting results concerning the anti-SARS-CoV-2 response in patients with solid organ transplants,in liver transplant recipients.Therefore,we would like to humbly state a few points for consideration involving liver transplant recipients and COVID-19,such as the time since transplantation,comorbidities,and immunosuppressive regimens.展开更多
Recent manuscripts described the incidence of vitamin D hypovitaminosis in coronavirus disease 2019(COVID-19)patients.Vitamin D deficiency is also common in patients with comorbidities that are associated with a poor ...Recent manuscripts described the incidence of vitamin D hypovitaminosis in coronavirus disease 2019(COVID-19)patients.Vitamin D deficiency is also common in patients with comorbidities that are associated with a poor COVID-19 prognosis.In this letter,we review the literature regarding the association of comorbidities,vitamin D deficiency,and COVID-19.展开更多
基金Supported by RWA holds a fellowship from FundaÇǎo de Amparo à Pesquisa do Estado de Sāo Paulo (FAPESP),No.19/02679-7。
文摘Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) infection can progress to a severe respiratory and systemic disease named coronavirus disease–2019(COVID-19). The most common symptoms are fever and respiratory discomfort. Nevertheless, gastrointestinal infections have been reported, with symptoms such as diarrhea, nausea, vomiting, abdominal pain, and lack of appetite. Importantly, SARS-CoV-2 can remain positive in fecal samples after nasopharyngeal clearance. After gastrointestinal SARS-CoV-2 infection and other viral gastrointestinal infections, some patients may develop alterations in the gastrointestinal microbiota. In addition, some COVID-19 patients may receive antibiotics, which may also disturb gastrointestinal homeostasis. In summary, the gastrointestinal system, gut microbiome, and gut-lung axis may represent an important role in the development, severity, and treatment of COVID-19. Therefore, in this review, we explore the current pieces of evidence of COVID-19 gastrointestinal manifestations, possible implications, and interventions.
文摘The recent manuscript entitled“Relationship between clinical features and intestinal microbiota in Chinese patients with ulcerative colitis”reported a difference in the intestinal microbiota of patients with ulcerative colitis according to the severity of the colitis.The influence of the intestinal microbiota on the development and progress of gastrointestinal disorders is well established.Besides the diversity in the microbiome,the presence of virulence factors and toxins by commensal bacteria may affect an extensive variety of cellular processes,contributing to the induction of a proinflammatory environment.
基金Fundação de AmparoàPesquisa do Estado de São Paulo(FAPESP),No.19/02679-7 and No.20/13148-0.
文摘The recent manuscript reviewed investigations involving liver damage in coronavirus disease 2019(COVID-19)patients,and COVID-19 in patients with previous chronic hepatological diseases,such as patients with liver graft.The literature presents several conflicting results concerning the anti-SARS-CoV-2 response in patients with solid organ transplants,in liver transplant recipients.Therefore,we would like to humbly state a few points for consideration involving liver transplant recipients and COVID-19,such as the time since transplantation,comorbidities,and immunosuppressive regimens.
基金RWA holds a fellowship from Fundação de AmparoàPesquisa do Estado de São Paulo(FAPESP),No.19/02679-7.
文摘Recent manuscripts described the incidence of vitamin D hypovitaminosis in coronavirus disease 2019(COVID-19)patients.Vitamin D deficiency is also common in patients with comorbidities that are associated with a poor COVID-19 prognosis.In this letter,we review the literature regarding the association of comorbidities,vitamin D deficiency,and COVID-19.
