Normal tissues are organized in a hierarchical model,whereas at the apex of these hierarchies reside stem cells (SCs) capable of self-renewal and of producing differentiated cellular progenies,leading to normal develo...Normal tissues are organized in a hierarchical model,whereas at the apex of these hierarchies reside stem cells (SCs) capable of self-renewal and of producing differentiated cellular progenies,leading to normal development and homeostasis.Alike,tumors are organized in a hierarchical manner,with cancer SCs residing at the apex,contributing to the development and nourishment of tumors .p53,the well-known 'guardian ofthe genome',possesses various roles in embryonic development as well as in adult SC life and serves as the ‘guardian of tissue hierarchy’.Moreover,p53 serves as a barrier for dedifferentiation and reprogramming by constraining the cells to a somatic state and preventing their conversion to SCs.On the contrary,the mutant forms of p53 that lost theirtumor suppressor activity and gain oncogenic functions serve as 'inducers oftissue anarchy' and promote cancer development.In this review,we discuss these two sides ofthe p53 token that sentence a tissue either to an ordered hierarchy and life or to anarchy and death.A better understanding of these processes may open new horizons for the development of new cancer therapies.展开更多
In this article (p.559, third paragraph), the reference in ‘The identified ESC gene signature-derived genes correlated with poor patient survival and human tumors harboring p53 hotspot mutations (Lonetto et al., 2018...In this article (p.559, third paragraph), the reference in ‘The identified ESC gene signature-derived genes correlated with poor patient survival and human tumors harboring p53 hotspot mutations (Lonetto et al., 2018)’ was incorrectly cited. It should be changed to ‘(Koifman et al., 2018)’. The conclusions of the review are not affected and the authors apologize for this error.展开更多
基金Research in the laboratory of V.R.is supported by a Center of Excellenee Grant from the Israel Science Foundation,a Center of Excellence Grant from the Flight Attendant Medical Research Institute,and the Israel Cancer Research Fund(ICRF).
文摘Normal tissues are organized in a hierarchical model,whereas at the apex of these hierarchies reside stem cells (SCs) capable of self-renewal and of producing differentiated cellular progenies,leading to normal development and homeostasis.Alike,tumors are organized in a hierarchical manner,with cancer SCs residing at the apex,contributing to the development and nourishment of tumors .p53,the well-known 'guardian ofthe genome',possesses various roles in embryonic development as well as in adult SC life and serves as the ‘guardian of tissue hierarchy’.Moreover,p53 serves as a barrier for dedifferentiation and reprogramming by constraining the cells to a somatic state and preventing their conversion to SCs.On the contrary,the mutant forms of p53 that lost theirtumor suppressor activity and gain oncogenic functions serve as 'inducers oftissue anarchy' and promote cancer development.In this review,we discuss these two sides ofthe p53 token that sentence a tissue either to an ordered hierarchy and life or to anarchy and death.A better understanding of these processes may open new horizons for the development of new cancer therapies.
文摘In this article (p.559, third paragraph), the reference in ‘The identified ESC gene signature-derived genes correlated with poor patient survival and human tumors harboring p53 hotspot mutations (Lonetto et al., 2018)’ was incorrectly cited. It should be changed to ‘(Koifman et al., 2018)’. The conclusions of the review are not affected and the authors apologize for this error.
