Currently,clinical strategies for the treatment of wounds are limited,especially in terms of achieving rapid wound healing.In recent years,based on the technique of electrospinning(ES),cell electrospinning(C-ES)has be...Currently,clinical strategies for the treatment of wounds are limited,especially in terms of achieving rapid wound healing.In recent years,based on the technique of electrospinning(ES),cell electrospinning(C-ES)has been developed to better repair related tissues or organs(such as skin,fat and muscle)by encapsulating living cells in a microfiber or nanofiber environment and constructing 3D living fiber scaffolds.Therefore,C-ES has promising prospects for promoting wound healing.In this article,C-ES technology and its advantages,the differences between CES and traditional ES,the parameters suitable for maintaining cytoactivity,and material selection and design issues are summarized.In addition,we review the application of C-ES in the fields of biomaterials and cells.Finally,the limitations and improved methods of C-ES are discussed.In conclusion,the potential advantages,limitations and prospects of C-ES application in wound healing are presented.展开更多
基金supported by the Competitive Projects for Science and Technology Innovation and Development of Gansu Province(2018ZX-10)Gansu Provincial Key Research and Development Project-International Science and Technology Cooperation(22YF7WA013)+3 种基金Gansu Provincial Department of Science and Technology,Gansu Provincial Science and Technology Program(Nature Science Foundation)-Excellent Doctoral Program(22JR5RA893)Lanzhou Talent Innovation and Venture Project(2017-RC-31)CSA West China Clinical Research Fund(CSA-W2022-11)Clinical Research Project of Hospital of Stomatology Lanzhou University(lzukqky-2022-t06).
文摘Currently,clinical strategies for the treatment of wounds are limited,especially in terms of achieving rapid wound healing.In recent years,based on the technique of electrospinning(ES),cell electrospinning(C-ES)has been developed to better repair related tissues or organs(such as skin,fat and muscle)by encapsulating living cells in a microfiber or nanofiber environment and constructing 3D living fiber scaffolds.Therefore,C-ES has promising prospects for promoting wound healing.In this article,C-ES technology and its advantages,the differences between CES and traditional ES,the parameters suitable for maintaining cytoactivity,and material selection and design issues are summarized.In addition,we review the application of C-ES in the fields of biomaterials and cells.Finally,the limitations and improved methods of C-ES are discussed.In conclusion,the potential advantages,limitations and prospects of C-ES application in wound healing are presented.
