Q fever is an uncommon zoonotic rickettsial disease with no exanthem or speci fic cutaneous lesions. Only nonspecific cutaneous involvement has been reported to date. A 69- year-old Spanish woman with chronic myelogen...Q fever is an uncommon zoonotic rickettsial disease with no exanthem or speci fic cutaneous lesions. Only nonspecific cutaneous involvement has been reported to date. A 69- year-old Spanish woman with chronic myelogenous leukaemia deve loped fever and two subcutaneous nodules. The patient complained of extreme pain . Biopsy revealed a granulomatous lobular panniculitis with a characteristic ‘ fibrin ring’ or ‘ doughnut’ appearance: fibrin and inflammatory cells arran ged around a central clear space. Changes of membranous lipodystrophy were also found. Q fever serological studies were positive. Our patient had panniculitis w ith singular histopathological features. These histopathological changes have be en described in liver and bone marrow of patients with Q fever. To the best of o ur knowledge, this cutaneous involvement due to Q fever has not previously been described in the literature.展开更多
Extraskeletal osteosarcoma represents approximately 1% of soft tissue sarco mas and approximately 4% of all osteosarcomas. It is therefore much rarer than osteosarcoma arising primarily in bone.1 Skin as a primary sit...Extraskeletal osteosarcoma represents approximately 1% of soft tissue sarco mas and approximately 4% of all osteosarcomas. It is therefore much rarer than osteosarcoma arising primarily in bone.1 Skin as a primary site has seldom been reported.2- 6 This report describes an extraskeletal osteosarcoma of the skin under a previously electrodessicated actinic keratosis.展开更多
文摘Q fever is an uncommon zoonotic rickettsial disease with no exanthem or speci fic cutaneous lesions. Only nonspecific cutaneous involvement has been reported to date. A 69- year-old Spanish woman with chronic myelogenous leukaemia deve loped fever and two subcutaneous nodules. The patient complained of extreme pain . Biopsy revealed a granulomatous lobular panniculitis with a characteristic ‘ fibrin ring’ or ‘ doughnut’ appearance: fibrin and inflammatory cells arran ged around a central clear space. Changes of membranous lipodystrophy were also found. Q fever serological studies were positive. Our patient had panniculitis w ith singular histopathological features. These histopathological changes have be en described in liver and bone marrow of patients with Q fever. To the best of o ur knowledge, this cutaneous involvement due to Q fever has not previously been described in the literature.
文摘Extraskeletal osteosarcoma represents approximately 1% of soft tissue sarco mas and approximately 4% of all osteosarcomas. It is therefore much rarer than osteosarcoma arising primarily in bone.1 Skin as a primary site has seldom been reported.2- 6 This report describes an extraskeletal osteosarcoma of the skin under a previously electrodessicated actinic keratosis.
