经支气管镜大容量肺灌洗治疗尘肺病合并慢性阻塞性肺疾病的疗效分析

目的评价经支气管镜大容量肺灌洗对尘肺病合并慢性阻塞性肺疾病(COPD)患者的临床症状及肺功能的改善作用。方法 103例尘肺病合并COPD患者随机分为治疗组54例,给予经支气管镜大容量肺灌洗治疗,对照组49例。观察患者治疗前、治疗后12、24和48周运动耐量、呼吸困难评分、6 min步行试验距离(6MWD)、圣乔治问卷评分(SGRQ)以及肺功能变化。并记录灌洗时的不良反应。结果两组患者第12、24和48周医学研究委员会(MRC)呼吸困难评分均较治疗前下降(P <0.05),但治疗组较对照组下降更明显(P <0.05);治疗组各时点6MWD值较前明显增加,SGRQ较治疗前下降,差异均有统计学意义(P <0.05),而对照组有所改善,但与治疗前比较差异无统计学意义(P>0.05);治疗组中各项指标较对照组改善(P <0.05)。治疗组12、24和48周用力肺活量(FVC)、第1秒用力肺活量(FEV1)均较治疗前明显增加(P <0.05);对照组与治疗前比较无差异,治疗组肺功能改善优于对照组(P <0.05)。结论经支气管镜大容量肺灌洗治疗尘肺病合并COPD安全、有效,值得临床推广。

细胞核相关抗原(Ki67)和p53表达对非小细胞肺癌患者预后的意义

目的检测非小细胞肺癌患者肿瘤组织中细胞核相关抗原Ki-67(Ki67)和p53的表达水平,探讨其对患者预后(生存率)判断的意义。方法用免疫组织化学染色半定量检测非小细胞肺癌患者肿瘤组织中的Ki67和p53表达水平。对患者进行随访,分析Ki67和p53表达水平与患者生存时间和生存率的关系。结果相关性分析结果表明,Ki67阳性细胞率与非小细胞肺癌患者生存时间具有较弱的相关性(r=-0.200,P=0.030),p53阳性细胞率与非小细胞肺癌患者生存时间无相关性(r=0.003,P=0.050)。单因素分析结果提示,Ki67和p53共表达以及原发肿瘤局部淋巴结远处转移(TNM)分期对患者生存期有影响,差异有统计学意义(P=0.000)。当Ki67和p53均低表达时,患者的中位生存时间及1~5年生存率均高于平均水平。预后影响因素Cox回归分析表明,TNM分期越低,患者中位生存时间越长,死亡风险越低。结论 TNM分期是影响肺癌预后的指标,TNM分期越高,患者死亡风险越大。Ki67和p53均低表达时,中位生存时间及1~5年生存率均高于平均水平,提示Ki67和p53联合检测可为非小细胞肺癌早期诊断及预后判断提供辅助依据。

Charge-state populations for the neon-XFEL system

The interaction between neon and x-ray free-electron lasers with different laser parameters is systematically studied by solving a set of coupled rate equations. As an example, the evolution of 1s^12 s^22 p^6 configuration is given under different incident photon numbers, pulse widths, and photon energies. We have also determined all of the charge-state populations as a function of three laser pulse parameters by averaging over time. The result shows that the variations of these charge-state populations demonstrate a pattern when the pulse width is shorter than 10 fs: some of the charge-states decrease rapidly,while the others rise but remain relatively constant for pulse width larger than 10 fs. The variation of the average charge with three parameters has also obtained. The average charge decreases for a pulse width shorter than 10 fs but remains basically unchanged for a pulse width longer than 10 fs.

A Frost Heaving Prediction Approach for Ground Uplift Simulation Due to Freeze-Sealing Pipe Roof Method

Freeze-sealing pipe roof method is applied in the Gongbei tunnel,which causes the ground surface uplift induced by frost heave.A frost heaving prediction approach based on the coefficient of cold expansion is proposed to simulate the ground deformation of the Gongbei tunnel.The coefficient of cold expansion in the model and the frost heaving rate from the frost heave test under the hydration condition can achieve a good correspondence making the calculation result closer to the actual engineering.The ground surface uplift along the lateral and longitudinal direction are respectively analyzed and compared with the field measured data to validate the model.The results show that a good agreement between the frost heaving prediction model and the field measured data verifies the rationality and applicability of the proposed model.The maximum uplift of the Gongbei tunnel appears at the center of the model,gradually decreasing along with the lateral and longitudinal directions.The curve in the lateral direction presents a normal distribution due to the influence of the constraint of two sides,while the one along the lateral direction shapes like a parabola with the opening downward due to the temperature field distribution.The model provides a reference for frost heaving engineering calculation.

Energy levels and transition data of 3p^(6)3d^(8)and 3p^(5)3d^(9)configurations in Fe-like ions(Z=57,60,62,64,65)

Atomic data of highly charged ions(HCIs)offer an attractive means for plasma diagnostic and stars identification,and the investigations on atomic data are highly desirable.Herein,based on the fully relativistic multi-configuration Dirac–Hartree–Fock(MCDHF)method,we have performed calculations of the fine-structure energy levels,wavelengths,transition rates,oscillator strengths,and line strengths for the lowest 21 states of 3p^(6)3d^(8)–3p^(5)3d^(9)electric dipole(E1)transitions configurations in Fe-like ions(Z=57,60,62,64,65).The correlation effects of valence–valence(VV)and core–valence(CV)electrons were systematically considered.In addition,we have taken into account transverse-photon(Breit)interaction and quantum electrodynamics(QED)corrections to treat accurately the atomic state wave functions in the final relativistic configuration interaction(RCI)calculations.Our calculated energy levels and transition wavelengths are in excellent agreement with the available experimental and theoretical results.Most importantly,we predicted some new transition parameters that have not yet been reported.These data would further provide critical insights into better analyzing the physical processes of various astrophysical plasmas.

低剂量X射线诱导胃癌细胞SGC7901适应性反应的实验研究(英文)

Objective: We aimed to study the effect and mechanism of low-dose radiation (LDR) on adaptive response of gastric cancer cell. Methods: SGC7901 cells were cultured in vitro, and divided into 4 groups: control group (D0 group), low-dose radiation group (D1 group, 75 mGy), high-dose radiation group (D2 group, 2 Gy), low-dose plus high-dose radiation group (D1 + D2 group, 75 mGy + 2 Gy, the interval of low and high-dose radiation being 8 h). Cell inhibition rate was detected by cytometry and CCK8 method; the proportion of cell cycle at different times after irradiation was determined by using a flow cytometry. The ATM mRNA levels were detected by using quantitative real-time reverse transcription polymerase chain reaction (RT-PCR). Results: There was no significant different between groups D0 and D1, groups D2 and D1 + D2 cell inhibition rate (P > 0.05). There was a significant increase G2/M arrest in groups D2 and D1 + D2 than groups D0 and D1 after 6 h of radiation and did not recover at 48 h (P < 0.05). The ATM mRNA expression of group D2 and D1 + D2 increased highly than that of group D0 and D1 (P < 0.05). However, differences between group D2 and D1 + D2, group D0 and D1 were not statistical significant (P > 0.05). Conclusion: LDR cannot induce adaptive response in SGC7901 cells in vitro, which may be associated the regulation of cell cycle, and its ATM mRNA expression cannot be affected by 75 mGy X-ray radiation.

Electrochemical reconstruction: a new perspective on Sn metal-organic complex microbelts as robust anode for lithium storage

Tin-based materials with high theoretical capacity and suitable working voltage are ideal anode materials for lithium-ion batteries(LIBs). However, to overcome their shortcomings(volume expansion and inferior stability), the preparation processes are usually complicated and expensive. Herein, a tin-based metal-organic complex(tin 1,2-benzenedicarboxylic acid, Sn-BDC)with one-dimensional microbelt morphology is synthesized by a facile, rapid and low-cost co-precipitation method, and served as anode material for LIBs without any post-treatment. Sn-BDC exhibits a high reversible capacity with609/440 m Ah·g^(-1) at 50/2000 m A·g^(-1), and robust cycling stability of 856 m Ah·g^(-1) after 200 cycles at 200 m A·g^(-1),which are obviously superior to that of the Sn Ox/C counterparts. Moreover, an electrochemical reconstruction perspective on the lithium storage mechanism of Sn-BDC is proposed by systematic ex-situ characterizations. The reconstructed SnO_(2) replaces Sn-BDC and becomes the active material in the subsequent cycles. As the by-product of the lithiation reaction, the formed Li-based metal-organic complex(Li-BDC, wrapped around the reconstructed SnO_(2)) plays an important role in alleviating volume expansion and accelerating the charge transfer kinetics.This work is beneficial to design and construct the new electrode materials based on the electrochemical reconstruction for advanced LIBs.

Detection of metastasis of mediastinal lymph nodes in lung cancer patients with an artificial intelligence model

To the Editor:Lung cancer leads to the largest number of cancer-associated deaths in the world.As the main means of the spreading of lung cancer,lymph node metastasis is related to the strategy for its treatment and the prognosis of the patients.[1]According to guidelines of the National Comprehensive Cancer Network,once mediastinal lymph nodes have been involved,patients are considered to have reached an advanced stage of lung cancer,and the treatment strategy should be different.[2]Computed tomography(CT)is a common method for the preoperative prediction of lymph node metastasis among lung cancer patients.However,not all abnormal lymph nodes can be recognized preoperatively with CT.Thus,more accurate prediction of lymph node metastasis is important for lung cancer treatment.

Precursor compound enabled formation of aqueous-phase CdSe magic-size clusters at room temperature

The formation pathway of aqueous-phase colloidal semiconductor magic-size clusters(MSCs)remains unrevealed.In the present work,we demonstrate,for the first time,a precursor compound(PC)-enabled formation pathway of aqueous-phase CdSe MSCs exhibiting a sharp absorption peaking at about 420 nm(MSC-420).The CdSe MSC-420 is synthesized with CdCl2 and selenourea as the respective Cd and Se sources,and with 3-mercaptopropionic acid or L-cysteine as a ligand.Absorption featureless CdSe PCs form first in the aqueous reaction batches,which transform to MSC-420 in the presence of primary amines.The coordination between primary amine and Cd^(2+)on PCs may be responsible to the PC-to-MSC transformation.Upon increasing the reactant concentrations or decreasing the CdCl_(2)-ligand feed molar ratios,the Cd precursor self-assembles into large aggregates,which may encapsulate the resulting CdSe PCs and inhibit their transformation to MSC-420.The present study sheds essential light on the syntheses and formation mechanisms of nanocrystals.

ε-FeOOH在中下地幔储存的证据及其对水循环的意义

地球内部转换带与核幔边界的水对地球的分层、元素循环以及地核组成等方面都有十分重要的影响.如果水是在地球表面与内部圈层间循环的话,那么理论上在下地幔也应该有水的通道,而且该水通道的地震地磁学特征应有别于其周围的下地幔环境.在本次工作中,利用动静高压结合的方法(二级轻气炮+金刚石压腔)并综合理论计算系统研究了ε-FeOOH在下地幔温压范围内的波速与电导率剖面及其内部机制.我们发现,在50 GPa左右由于铁的电子自旋相变的影响,ε-FeOOH的电导率有3个数量级的急剧升高而其纵波波速会突然下降16.8%左右.结合全球地震地磁学数据分析,ε-FeOOH在这个压力范围的高导低波现象恰好与全球范围内在1200 km深度左右的某些高导低波的冷俯冲带区域相吻合.含水ε-FeOOH或者其他含铁相可能具有的这些独特性质或许可以作为水在中下地幔通过的证据.